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Article: Three-dimensional nanocomposite scaffolds fabricated via selective laser sintering for bone tissue engineering

TitleThree-dimensional nanocomposite scaffolds fabricated via selective laser sintering for bone tissue engineering
Authors
KeywordsBiomimetic
Bone tissue engineering
Nanocomposite
Scaffold
Selective laser sintering
Issue Date2010
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/actabiomat
Citation
Acta Biomaterialia, 2010, v. 6 n. 12, p. 4495-4505 How to Cite?
AbstractBionanocomposites formed by combining biodegradable polymers and nanosized osteoconductive inorganic solids have been regarded as promising biomimetic systems which possess much improved structural and functional properties for bone tissue regeneration. In this study three-dimensional nanocomposite scaffolds based on calcium phosphate (Ca-P)/poly(hydroxybutyrate-co- hydroxyvalerate) (PHBV) and carbonated hydroxyapatite (CHAp)/poly(l-lactic acid) (PLLA) nanocomposite microspheres were successfully fabricated using selective laser sintering, which is a rapid prototyping technology. The sintered scaffolds had controlled material microstructure, totally interconnected porous structure and high porosity. The morphology and mechanical properties of Ca-P/PHBV and CHAp/PLLA nanocomposite scaffolds as well as PHBV and PLLA polymer scaffolds were studied. In vitro biological evaluation showed that SaOS-2 cells had high cell viability and normal morphology and phenotype after 3 and 7 days culture on all scaffolds. The incorporation of Ca-P nanoparticles significantly improved cell proliferation and alkaline phosphatase activity for Ca-P/PHBV scaffolds, whereas CHAp/PLLA nanocomposite scaffolds exhibited a similar level of cell response compared with PLLA polymer scaffolds. The nanocomposite scaffolds provide a biomimetic environment for osteoblastic cell attachment, proliferation and differentiation and have great potential for bone tissue engineering applications. © 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/139557
ISSN
2023 Impact Factor: 9.4
2023 SCImago Journal Rankings: 1.925
ISI Accession Number ID
Funding AgencyGrant Number
University of Hong Kong (HKU)
Hong Kong Research Grants CouncilHKU 7176/08E
Funding Information:

B. Duan thanks The University of Hong Kong (HKU) for the award of a university scholarship. This work was supported by an HKU research grant and partly by a GRF grant (HKU 7176/08E) from the Hong Kong Research Grants Council. Assistance provided by technical staff in the Department of Mechanical Engineering, HKU, is acknowledged.

References

 

DC FieldValueLanguage
dc.contributor.authorDuan, Ben_HK
dc.contributor.authorWang, Men_HK
dc.contributor.authorZhou, WYen_HK
dc.contributor.authorCheung, WLen_HK
dc.contributor.authorLi, ZYen_HK
dc.contributor.authorLu, WWen_HK
dc.date.accessioned2011-09-23T05:51:37Z-
dc.date.available2011-09-23T05:51:37Z-
dc.date.issued2010en_HK
dc.identifier.citationActa Biomaterialia, 2010, v. 6 n. 12, p. 4495-4505en_HK
dc.identifier.issn1742-7061en_HK
dc.identifier.urihttp://hdl.handle.net/10722/139557-
dc.description.abstractBionanocomposites formed by combining biodegradable polymers and nanosized osteoconductive inorganic solids have been regarded as promising biomimetic systems which possess much improved structural and functional properties for bone tissue regeneration. In this study three-dimensional nanocomposite scaffolds based on calcium phosphate (Ca-P)/poly(hydroxybutyrate-co- hydroxyvalerate) (PHBV) and carbonated hydroxyapatite (CHAp)/poly(l-lactic acid) (PLLA) nanocomposite microspheres were successfully fabricated using selective laser sintering, which is a rapid prototyping technology. The sintered scaffolds had controlled material microstructure, totally interconnected porous structure and high porosity. The morphology and mechanical properties of Ca-P/PHBV and CHAp/PLLA nanocomposite scaffolds as well as PHBV and PLLA polymer scaffolds were studied. In vitro biological evaluation showed that SaOS-2 cells had high cell viability and normal morphology and phenotype after 3 and 7 days culture on all scaffolds. The incorporation of Ca-P nanoparticles significantly improved cell proliferation and alkaline phosphatase activity for Ca-P/PHBV scaffolds, whereas CHAp/PLLA nanocomposite scaffolds exhibited a similar level of cell response compared with PLLA polymer scaffolds. The nanocomposite scaffolds provide a biomimetic environment for osteoblastic cell attachment, proliferation and differentiation and have great potential for bone tissue engineering applications. © 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.en_HK
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/actabiomaten_HK
dc.relation.ispartofActa Biomaterialiaen_HK
dc.subjectBiomimeticen_HK
dc.subjectBone tissue engineeringen_HK
dc.subjectNanocompositeen_HK
dc.subjectScaffolden_HK
dc.subjectSelective laser sinteringen_HK
dc.subject.meshBone and Bones - physiology-
dc.subject.meshLasers-
dc.subject.meshNanocomposites - chemistry - ultrastructure-
dc.subject.meshTissue Engineering - methods-
dc.subject.meshTissue Scaffolds - chemistry-
dc.titleThree-dimensional nanocomposite scaffolds fabricated via selective laser sintering for bone tissue engineeringen_HK
dc.typeArticleen_HK
dc.identifier.emailWang, M:memwang@hku.hken_HK
dc.identifier.emailCheung, WL:wlcheung@hkucc.hku.hken_HK
dc.identifier.emailLu, WW:wwlu@hku.hken_HK
dc.identifier.authorityWang, M=rp00185en_HK
dc.identifier.authorityCheung, WL=rp00103en_HK
dc.identifier.authorityLu, WW=rp00411en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.actbio.2010.06.024en_HK
dc.identifier.pmid20601244-
dc.identifier.scopuseid_2-s2.0-77958101381en_HK
dc.identifier.hkuros193975en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77958101381&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume6en_HK
dc.identifier.issue12en_HK
dc.identifier.spage4495en_HK
dc.identifier.epage4505en_HK
dc.identifier.eissn1878-7568-
dc.identifier.isiWOS:000284385300004-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridDuan, B=7005042335en_HK
dc.identifier.scopusauthoridWang, M=15749714100en_HK
dc.identifier.scopusauthoridZhou, WY=26636766600en_HK
dc.identifier.scopusauthoridCheung, WL=7202743084en_HK
dc.identifier.scopusauthoridLi, ZY=35784563200en_HK
dc.identifier.scopusauthoridLu, WW=7404215221en_HK
dc.identifier.citeulike10161178-
dc.identifier.issnl1742-7061-

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