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Article: Antisaccade performance in monozygotic twins discordant for schizophrenia: The Maudsley twin study

TitleAntisaccade performance in monozygotic twins discordant for schizophrenia: The Maudsley twin study
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date2006
PublisherAmerican Psychiatric Publishing, Inc. The Journal's web site is located at http://ajp.psychiatryonline.org
Citation
American Journal Of Psychiatry, 2006, v. 163 n. 3, p. 543-545 How to Cite?
AbstractObjective: Deficiency in antisaccade performance has been proposed as a schizophrenia endophenotype. Method: The authors assessed performance on an antisaccade task (and a prosaccade control condition) by 10 monozygotic twin pairs discordant for DSM-IV schizophrenia and 10 monozygotic healthy twin pairs matched for age, sex, and parental socioeconomic status. The authors computed antisaccade gain, latency, and error rate, as well as prosaccade gain and latency. Results: The schizophrenic twins made more antisaccade reflexive errors than the nonschizophrenic co-twins and comparison twins, who did not significantly differ from each other. The nonschizophrenic members of discordant pairs performed worse than the comparison twins on antisaccade gain and latency but did not differ from their schizophrenic co-twins on these variables. There were no differences on prosaccade performance. Antisaccade errors were correlated with negative symptoms in the patients. Conclusions: Antisaccade spatial accuracy and latency deficits may serve as markers of genetic liability for schizophrenia.
Persistent Identifierhttp://hdl.handle.net/10722/141860
ISSN
2023 Impact Factor: 15.1
2023 SCImago Journal Rankings: 4.321
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorEttinger, Uen_HK
dc.contributor.authorPicchioni, Men_HK
dc.contributor.authorHall, MHen_HK
dc.contributor.authorSchulze, Ken_HK
dc.contributor.authorToulopoulou, Ten_HK
dc.contributor.authorLandau, Sen_HK
dc.contributor.authorCrawford, TJen_HK
dc.contributor.authorMurray, RMen_HK
dc.date.accessioned2011-09-27T03:03:27Z-
dc.date.available2011-09-27T03:03:27Z-
dc.date.issued2006en_HK
dc.identifier.citationAmerican Journal Of Psychiatry, 2006, v. 163 n. 3, p. 543-545en_HK
dc.identifier.issn0002-953Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/141860-
dc.description.abstractObjective: Deficiency in antisaccade performance has been proposed as a schizophrenia endophenotype. Method: The authors assessed performance on an antisaccade task (and a prosaccade control condition) by 10 monozygotic twin pairs discordant for DSM-IV schizophrenia and 10 monozygotic healthy twin pairs matched for age, sex, and parental socioeconomic status. The authors computed antisaccade gain, latency, and error rate, as well as prosaccade gain and latency. Results: The schizophrenic twins made more antisaccade reflexive errors than the nonschizophrenic co-twins and comparison twins, who did not significantly differ from each other. The nonschizophrenic members of discordant pairs performed worse than the comparison twins on antisaccade gain and latency but did not differ from their schizophrenic co-twins on these variables. There were no differences on prosaccade performance. Antisaccade errors were correlated with negative symptoms in the patients. Conclusions: Antisaccade spatial accuracy and latency deficits may serve as markers of genetic liability for schizophrenia.en_HK
dc.languageengen_US
dc.publisherAmerican Psychiatric Publishing, Inc. The Journal's web site is located at http://ajp.psychiatryonline.orgen_HK
dc.relation.ispartofAmerican Journal of Psychiatryen_HK
dc.subjectChemicals And Cas Registry Numbersen_US
dc.titleAntisaccade performance in monozygotic twins discordant for schizophrenia: The Maudsley twin studyen_HK
dc.typeArticleen_HK
dc.identifier.emailToulopoulou, T:timothea@hku.hken_HK
dc.identifier.authorityToulopoulou, T=rp01542en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1176/appi.ajp.163.3.543en_HK
dc.identifier.pmid16513882-
dc.identifier.scopuseid_2-s2.0-33645897977en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33645897977&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume163en_HK
dc.identifier.issue3en_HK
dc.identifier.spage543en_HK
dc.identifier.epage545en_HK
dc.identifier.isiWOS:000235726000034-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridEttinger, U=6602766172en_HK
dc.identifier.scopusauthoridPicchioni, M=6507443795en_HK
dc.identifier.scopusauthoridHall, MH=14013171900en_HK
dc.identifier.scopusauthoridSchulze, K=7103137549en_HK
dc.identifier.scopusauthoridToulopoulou, T=8855468700en_HK
dc.identifier.scopusauthoridLandau, S=7101776972en_HK
dc.identifier.scopusauthoridCrawford, TJ=7102138474en_HK
dc.identifier.scopusauthoridMurray, RM=35406239400en_HK
dc.identifier.issnl0002-953X-

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