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Article: Intellectual asymmetry and genetic liability in first-degree relatives of probands with schizophrenia

TitleIntellectual asymmetry and genetic liability in first-degree relatives of probands with schizophrenia
Authors
Issue Date2006
PublisherRoyal College of Psychiatrists. The Journal's web site is located at http://bjp.rcpsych.org/
Citation
British Journal Of Psychiatry, 2006, v. 188 FEB., p. 186-187 How to Cite?
AbstractIntellectual asymmetry with superiority of verbal skills to spatial skills frequently characterises patients with schizophrenia, but it is unclear whether this pattern also reflects genetic susceptibility to the disorder. We examined the association of a continuous measure of genetic liability to schizophrenia with Verbal-Spatial Contrast IQ (an index of intellectual asymmetry) in 108 first-degree relatives without psychosis of probands with schizophrenia. Higher genetic liability was significantly associated with greater intellectual asymmetry in favour of verbal skills. Intellectual asymmetry with a relative superiority of verbal skills to spatial skills represents a putative endophenotype of schizophrenia.
Persistent Identifierhttp://hdl.handle.net/10722/141863
ISSN
2023 Impact Factor: 8.7
2023 SCImago Journal Rankings: 2.717
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKravariti, Een_HK
dc.contributor.authorToulopoulou, Ten_HK
dc.contributor.authorMapuaFilbey, Fen_HK
dc.contributor.authorSchulze, Ken_HK
dc.contributor.authorWalshe, Men_HK
dc.contributor.authorSham, Pen_HK
dc.contributor.authorMurray, RMen_HK
dc.contributor.authorMcDonald, Cen_HK
dc.date.accessioned2011-09-27T03:03:29Z-
dc.date.available2011-09-27T03:03:29Z-
dc.date.issued2006en_HK
dc.identifier.citationBritish Journal Of Psychiatry, 2006, v. 188 FEB., p. 186-187en_HK
dc.identifier.issn0007-1250en_HK
dc.identifier.urihttp://hdl.handle.net/10722/141863-
dc.description.abstractIntellectual asymmetry with superiority of verbal skills to spatial skills frequently characterises patients with schizophrenia, but it is unclear whether this pattern also reflects genetic susceptibility to the disorder. We examined the association of a continuous measure of genetic liability to schizophrenia with Verbal-Spatial Contrast IQ (an index of intellectual asymmetry) in 108 first-degree relatives without psychosis of probands with schizophrenia. Higher genetic liability was significantly associated with greater intellectual asymmetry in favour of verbal skills. Intellectual asymmetry with a relative superiority of verbal skills to spatial skills represents a putative endophenotype of schizophrenia.en_HK
dc.languageengen_US
dc.publisherRoyal College of Psychiatrists. The Journal's web site is located at http://bjp.rcpsych.org/en_HK
dc.relation.ispartofBritish Journal of Psychiatryen_HK
dc.titleIntellectual asymmetry and genetic liability in first-degree relatives of probands with schizophreniaen_HK
dc.typeArticleen_HK
dc.identifier.emailToulopoulou, T: timothea@hku.hken_HK
dc.identifier.emailSham, P: pcsham@hku.hken_HK
dc.identifier.authorityToulopoulou, T=rp01542en_HK
dc.identifier.authoritySham, P=rp00459en_HK
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1192/bjp.bp.104.008177en_HK
dc.identifier.pmid16449708-
dc.identifier.scopuseid_2-s2.0-31644437610en_HK
dc.identifier.hkuros134289-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-31644437610&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume188en_HK
dc.identifier.issueFEB.en_HK
dc.identifier.spage186en_HK
dc.identifier.epage187en_HK
dc.identifier.isiWOS:000235206600015-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridKravariti, E=8855469000en_HK
dc.identifier.scopusauthoridToulopoulou, T=8855468700en_HK
dc.identifier.scopusauthoridMapuaFilbey, F=8855468800en_HK
dc.identifier.scopusauthoridSchulze, K=7103137549en_HK
dc.identifier.scopusauthoridWalshe, M=8855469300en_HK
dc.identifier.scopusauthoridSham, P=34573429300en_HK
dc.identifier.scopusauthoridMurray, RM=35406239400en_HK
dc.identifier.scopusauthoridMcDonald, C=8749594800en_HK
dc.identifier.issnl0007-1250-

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