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Article: Reassortment events among swine influenza a viruses in China: Implications for the origin of the 2009 influenza pandemic
Title | Reassortment events among swine influenza a viruses in China: Implications for the origin of the 2009 influenza pandemic | ||||||||||
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Authors | |||||||||||
Issue Date | 2011 | ||||||||||
Publisher | American Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/ | ||||||||||
Citation | Journal Of Virology, 2011, v. 85 n. 19, p. 10279-10285 How to Cite? | ||||||||||
Abstract | That pigs may play a pivotal role in the emergence of pandemic influenza was indicated by the recent H1N1/2009 human pandemic, likely caused by a reassortant between viruses of the American triple-reassortant (TR) and Eurasian avian-like (EA) swine influenza lineages. As China has the largest human and pig populations in the world and is the only place where both TR and EA viruses have been reported to cocirculate, it is potentially the source of the H1N1/2009 pandemic virus. To examine this, the genome sequences of 405 swine influenza viruses from China were analyzed. Thirty-six TR and EA reassortant viruses were identified before and after the occurrence of the pandemic. Several of these TR-EA reassortant viruses had genotypes with most segments having the same lineage origin as the segments of the H1N1/2009 pandemic virus. However, these viruses were generated from independent reassortment events throughout our survey period and were not associated with the current pandemic. One TR-EA reassortant, which is least similar to the pandemic virus, has persisted since 2007, while all the other variants appear to be transient. Despite frequent reassortment events between TR and EA lineage viruses in China, evidence for the genesis of the 2009 pandemic virus in pigs in this region is still absent. © 2011, American Society for Microbiology. | ||||||||||
Persistent Identifier | http://hdl.handle.net/10722/142405 | ||||||||||
ISSN | 2023 Impact Factor: 4.0 2023 SCImago Journal Rankings: 1.378 | ||||||||||
PubMed Central ID | |||||||||||
ISI Accession Number ID |
Funding Information: We acknowledge the National Institutes of Health (National Institute of Allergy and Infectious Diseases contract HSN266200700005C), the Li Ka Shing Foundation, and the Area of Excellence Scheme of the UGC of the Hong Kong SAR (grant AoE/M-12/06) for financial support. | ||||||||||
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DC Field | Value | Language |
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dc.contributor.author | Lam, TT | en_HK |
dc.contributor.author | Zhu, H | en_HK |
dc.contributor.author | Wang, J | en_HK |
dc.contributor.author | Smith, DK | en_HK |
dc.contributor.author | Holmes, EC | en_HK |
dc.contributor.author | Webster, RG | en_HK |
dc.contributor.author | Webby, R | en_HK |
dc.contributor.author | Peiris, JM | en_HK |
dc.contributor.author | Guan, Y | en_HK |
dc.date.accessioned | 2011-10-28T02:45:23Z | - |
dc.date.available | 2011-10-28T02:45:23Z | - |
dc.date.issued | 2011 | en_HK |
dc.identifier.citation | Journal Of Virology, 2011, v. 85 n. 19, p. 10279-10285 | en_HK |
dc.identifier.issn | 0022-538X | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/142405 | - |
dc.description.abstract | That pigs may play a pivotal role in the emergence of pandemic influenza was indicated by the recent H1N1/2009 human pandemic, likely caused by a reassortant between viruses of the American triple-reassortant (TR) and Eurasian avian-like (EA) swine influenza lineages. As China has the largest human and pig populations in the world and is the only place where both TR and EA viruses have been reported to cocirculate, it is potentially the source of the H1N1/2009 pandemic virus. To examine this, the genome sequences of 405 swine influenza viruses from China were analyzed. Thirty-six TR and EA reassortant viruses were identified before and after the occurrence of the pandemic. Several of these TR-EA reassortant viruses had genotypes with most segments having the same lineage origin as the segments of the H1N1/2009 pandemic virus. However, these viruses were generated from independent reassortment events throughout our survey period and were not associated with the current pandemic. One TR-EA reassortant, which is least similar to the pandemic virus, has persisted since 2007, while all the other variants appear to be transient. Despite frequent reassortment events between TR and EA lineage viruses in China, evidence for the genesis of the 2009 pandemic virus in pigs in this region is still absent. © 2011, American Society for Microbiology. | en_HK |
dc.language | eng | en_US |
dc.publisher | American Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/ | en_HK |
dc.relation.ispartof | Journal of Virology | en_HK |
dc.rights | Journal of Virology. Copyright © American Society for Microbiology. | - |
dc.rights | Copyright © American Society for Microbiology, [insert journal name, volume number, page numbers, and year] | - |
dc.subject.mesh | Influenza A virus - genetics - isolation and purification | - |
dc.subject.mesh | Orthomyxoviridae Infections - veterinary - virology | - |
dc.subject.mesh | Reassortant Viruses - genetics - isolation and purification | - |
dc.subject.mesh | Recombination, Genetic | - |
dc.subject.mesh | Swine Diseases - virology | - |
dc.title | Reassortment events among swine influenza a viruses in China: Implications for the origin of the 2009 influenza pandemic | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Lam, TT: ttylam@hku.hk | en_HK |
dc.identifier.email | Zhu, H: zhuhch@hku.hk | en_HK |
dc.identifier.email | Peiris, JM: malik@hkucc.hku.hk | en_HK |
dc.identifier.email | Guan, Y: yguan@hkucc.hku.hk | en_HK |
dc.identifier.authority | Lam, TT=rp01733 | en_HK |
dc.identifier.authority | Zhu, H=rp01535 | en_HK |
dc.identifier.authority | Peiris, JM=rp00410 | en_HK |
dc.identifier.authority | Guan, Y=rp00397 | en_HK |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1128/JVI.05262-11 | en_HK |
dc.identifier.pmid | 21795347 | - |
dc.identifier.pmcid | PMC3196454 | - |
dc.identifier.scopus | eid_2-s2.0-80053947748 | en_HK |
dc.identifier.hkuros | 196748 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-80053947748&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 85 | en_HK |
dc.identifier.issue | 19 | en_HK |
dc.identifier.spage | 10279 | en_HK |
dc.identifier.epage | 10285 | en_HK |
dc.identifier.eissn | 1098-5514 | - |
dc.identifier.isi | WOS:000296253900060 | - |
dc.publisher.place | United States | en_HK |
dc.relation.project | Control of Pandemic and Inter-pandemic Influenza | - |
dc.identifier.scopusauthorid | Lam, TT=36775821700 | en_HK |
dc.identifier.scopusauthorid | Zhu, H=25724029300 | en_HK |
dc.identifier.scopusauthorid | Wang, J=35228130300 | en_HK |
dc.identifier.scopusauthorid | Smith, DK=7410351143 | en_HK |
dc.identifier.scopusauthorid | Holmes, EC=35433598300 | en_HK |
dc.identifier.scopusauthorid | Webster, RG=36048363100 | en_HK |
dc.identifier.scopusauthorid | Webby, R=35448064800 | en_HK |
dc.identifier.scopusauthorid | Peiris, JM=7005486823 | en_HK |
dc.identifier.scopusauthorid | Guan, Y=7202924055 | en_HK |
dc.identifier.issnl | 0022-538X | - |