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- Publisher Website: 10.1016/j.stem.2010.09.012
- Scopus: eid_2-s2.0-78049510298
- PMID: 21040899
- WOS: WOS:000284390500009
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Article: Inhibition of sca-1-positive skeletal stem cell recruitment by alendronate blunts the anabolic effects of parathyroid hormone on bone remodeling
Title | Inhibition of sca-1-positive skeletal stem cell recruitment by alendronate blunts the anabolic effects of parathyroid hormone on bone remodeling | ||||
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Authors | |||||
Issue Date | 2010 | ||||
Publisher | Cell Press. The Journal's web site is located at http://www.cellstemcell.com | ||||
Citation | Cell Stem Cell, 2010, v. 7 n. 5, p. 571-580 How to Cite? | ||||
Abstract | The anabolic effects of parathyroid hormone (PTH) on bone formation are impaired by concurrent use of antiresorptive drugs. We found that the release of active transforming growth factor (TGF)-β1 during osteoclastic bone resorption is inhibited by alendronate. We showed that mouse Sca-1-positive (Sca-1 +) bone marrow stromal cells are a skeletal stem cell subset, which are recruited to bone remodeling sites by active TGF-β1 in response to bone resorption. Alendronate inhibits the release of active TGF-β1 and the recruitment of Sca-1 + skeletal stem cells for the bone formation. The observation was validated in a Tgfb1 -/- mouse model, in which the anabolic effects of PTH on bone formation are diminished. The PTH-stimulated recruitment of injected mouse Sca-1 + cells to the resorptive sites was inhibited by alendronate. Thus, inhibition of active TGF-β1 release by alendronate reduces the recruitment of Sca-1 + skeletal stem cells and impairs the anabolic action of PTH in bone. © 2010 Elsevier Inc. | ||||
Persistent Identifier | http://hdl.handle.net/10722/142445 | ||||
ISSN | 2023 Impact Factor: 19.8 2023 SCImago Journal Rankings: 10.253 | ||||
ISI Accession Number ID |
Funding Information: The authors thank Elaine P. Henze (Editorial Services Department of Orthopaedic Surgery, Johns Hopkins University) for editing the manuscript and Dr. Brendan J. Canning (Asthma and Allergy Center, Johns Hopkins University) for providing guinea pig marrow cells. This research was supported by US National Institutes of Health grants DK0080898 and AR 053973 to X. Cao. | ||||
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Wu, X | en_HK |
dc.contributor.author | Pang, L | en_HK |
dc.contributor.author | Lei, W | en_HK |
dc.contributor.author | Lu, W | en_HK |
dc.contributor.author | Li, J | en_HK |
dc.contributor.author | Li, Z | en_HK |
dc.contributor.author | Frassica, FJ | en_HK |
dc.contributor.author | Chen, X | en_HK |
dc.contributor.author | Wan, M | en_HK |
dc.contributor.author | Cao, X | en_HK |
dc.date.accessioned | 2011-10-28T02:46:08Z | - |
dc.date.available | 2011-10-28T02:46:08Z | - |
dc.date.issued | 2010 | en_HK |
dc.identifier.citation | Cell Stem Cell, 2010, v. 7 n. 5, p. 571-580 | en_HK |
dc.identifier.issn | 1934-5909 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/142445 | - |
dc.description.abstract | The anabolic effects of parathyroid hormone (PTH) on bone formation are impaired by concurrent use of antiresorptive drugs. We found that the release of active transforming growth factor (TGF)-β1 during osteoclastic bone resorption is inhibited by alendronate. We showed that mouse Sca-1-positive (Sca-1 +) bone marrow stromal cells are a skeletal stem cell subset, which are recruited to bone remodeling sites by active TGF-β1 in response to bone resorption. Alendronate inhibits the release of active TGF-β1 and the recruitment of Sca-1 + skeletal stem cells for the bone formation. The observation was validated in a Tgfb1 -/- mouse model, in which the anabolic effects of PTH on bone formation are diminished. The PTH-stimulated recruitment of injected mouse Sca-1 + cells to the resorptive sites was inhibited by alendronate. Thus, inhibition of active TGF-β1 release by alendronate reduces the recruitment of Sca-1 + skeletal stem cells and impairs the anabolic action of PTH in bone. © 2010 Elsevier Inc. | en_HK |
dc.language | eng | en_US |
dc.publisher | Cell Press. The Journal's web site is located at http://www.cellstemcell.com | en_HK |
dc.relation.ispartof | Cell Stem Cell | en_HK |
dc.subject.mesh | Alendronate - pharmacology | - |
dc.subject.mesh | Bone Remodeling - drug effects | - |
dc.subject.mesh | Membrane Proteins | - |
dc.subject.mesh | Parathyroid Hormone - antagonists and inhibitors | - |
dc.subject.mesh | Stem Cells - drug effects - physiology | - |
dc.title | Inhibition of sca-1-positive skeletal stem cell recruitment by alendronate blunts the anabolic effects of parathyroid hormone on bone remodeling | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1934-5909&volume=7&issue=5&spage=571&epage=580&date=2010&atitle=Inhibition+of+Sca-1-positive+skeletal+stem+cells+recruitment+by+alendronate+blunts+the+anabolic+effects+of+parathyroid+hormone+on+bone+remodeling, | - |
dc.identifier.email | Lu, W:wwlu@hku.hk | en_HK |
dc.identifier.authority | Lu, W=rp00411 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.stem.2010.09.012 | en_HK |
dc.identifier.pmid | 21040899 | - |
dc.identifier.scopus | eid_2-s2.0-78049510298 | en_HK |
dc.identifier.hkuros | 197080 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-78049510298&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 7 | en_HK |
dc.identifier.issue | 5 | en_HK |
dc.identifier.spage | 571 | en_HK |
dc.identifier.epage | 580 | en_HK |
dc.identifier.eissn | 1934-5909 | - |
dc.identifier.isi | WOS:000284390500009 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Wu, X=35867626100 | en_HK |
dc.identifier.scopusauthorid | Pang, L=13307644700 | en_HK |
dc.identifier.scopusauthorid | Lei, W=28367791400 | en_HK |
dc.identifier.scopusauthorid | Lu, W=7404215221 | en_HK |
dc.identifier.scopusauthorid | Li, J=36062945100 | en_HK |
dc.identifier.scopusauthorid | Li, Z=35867304900 | en_HK |
dc.identifier.scopusauthorid | Frassica, FJ=7006609242 | en_HK |
dc.identifier.scopusauthorid | Chen, X=37051752200 | en_HK |
dc.identifier.scopusauthorid | Wan, M=7202684871 | en_HK |
dc.identifier.scopusauthorid | Cao, X=7403370374 | en_HK |
dc.identifier.issnl | 1875-9777 | - |