Relation of serum leptin and adiponectin to cardiovascular risk factors in older adults: a Guangzhou Biobank Cohort Study-CVD

Abstract

目的 探討相對健康的中老年人血清瘦素與脂聯素水平與心腦血管疾病危險因素的相關性.方法 從'廣州生物庫隊列研究'中收集1515名相對健康的50歲及以上的中老年人個人資料及病史、體格檢查并測定血清空腹血糖、血脂、瘦素和脂聯素的水平.結果 (1)廣州市1515名的血清瘦素水平(x-±s)男女性分別為(3.90±2.36)ng/ml和(12.17±2.01)ng/ml;脂聯素水平男女性分別為(5.33±2.78)mg/L和(7.18±2.58)mg/L.(2)男女性血清瘦素和脂聯素水平均隨年齡增長而升高;在調整BMI后,男性瘦素水平仍隨年齡增長而顯著升高(趨勢檢驗P＜0.001),而女性其脂聯素水平也隨年齡增長而顯著升高(趨勢檢驗P＜0.05).(3)在調整年齡后,男女性血清瘦素和脂聯素水平均與吸煙狀態無明顯相關(P=0.09～0.76).(4)血清瘦素水平,男女性均隨腰圍、BMI、SBP、LDL-C和TG增加而顯著升高(P=0.04,＜0.001),同時還隨男性的DBP和空腹血糖升高及HDL-C降低而顯著升高(P=0.03～0.02).(5)血清脂聯素水平男女性均隨腹圍以及TG升高而下降(P=0.003,＜0.001),而男性血清脂聯素水平還隨BMI與空腹血糖升高及HDL-C水平下降而下降(P=0.05,＜0.001),女性則隨SBP和TC上升而下降(P=0.05～0.006).結論 廣州市相對健康的中老年人血清瘦素和脂聯索水平男性比女性低;男性瘦素水平和女性脂聯素水平同年齡增加呈顯著相關.血清瘦素升高和脂聯素下降與傳統心腦血管危險因素上升有關. Objective To study the serum leptin and adiponectin levels among relatively healthy older people and their association with traditional cardiovascular risk factors.Methods Personal medical history and blood sample were collected from 1515 older people of Guangzhou.Fasting serum glucose,lipids,leptin and adiponectin were measured.Results(1)In relatively healthy older adults aged 50 or above,from Guangzhou,the following data were seen:serum leptin levels(x-±s)in men and women were(3.90±2.36)ng/ml and(12.17 ±2.01)ng/ml respectively;serum adiponectin levels in men and women were(5.33 ± 2.78)mg/L and(7.18 ± 2.58)mg/L respectively.(2)Serum leptin and adiponectin level increased with age.After adjusting for body mass index,the trend for serum leptin level in men(P＜0.001)and adiponectin level in women(P＜0.05)were significantly associated with age.(3)No association was found between cigarette smoking and levels of leptin or adiponectin in both men and women after adjusting for age(P from 0.09 to 0.76).(4)In both men and women,serum leptin and adiponectin levels were positively associated with waist circumference/body mass index,systolic blood pressure,low-density lipoprotein cholesterol and triglyceride(P from 0.04 to＜0.001).In men,leptin was also significantly associated with the increase of diastolic blood pressure and glucose but decreased with high-density lipoprotein cholesterol(P from 0.03 to 0.02).(5)Decreased adiponectin level was associated with increased waist circumference and triglyceride in both men and women(P from 0.003 to＜0.001)and with the increased body mass index,fasting plasma glucose as well as with decreased high-density lipoprotein cholesterol in men(P from 0.05 to＜0.001)but with increased systolic blood pressure and total cholesterol in women(P from 0.05 to 0.006).Conclusion In Guangzhou city,among relatively healthy older adults aged 50 or above,their serum leptin and adiponectin levels were lower in men than in women.Serum leptin level in men and adiponectin level in women were significantly associated with the increase of age.Increased leptin and decreased adiponectin levels were associated with increased traditional cardiovascular risk factors.