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Article: Mechanical properties and in vitro response of strontium-containing hydroxyapatite/polyetheretherketone composites

TitleMechanical properties and in vitro response of strontium-containing hydroxyapatite/polyetheretherketone composites
Authors
Wong, KLWong, CTLiu, WCPan, HBFong, MKLam, WMCheung, WLTang, WMChiu, KYLuk, KDKLu, WW
KeywordsBioactivity
Hydroxyapatite
Mechanical
Polyetheretherketone
Strontium
Issue Date2009
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/biomaterials
Citation
Biomaterials, 2009, v. 30 n. 23-24, p. 3810-3817 How to Cite?
DOI: http://dx.doi.org/10.1016/j.biomaterials.2009.04.016
AbstractStrontium-containing hydroxyapatite/polyetheretherketone (Sr-HA/PEEK) composites were developed as alternative materials for load-bearing orthopaedic applications. The amount of strontium-containing hydroxyapatite (Sr-HA) incorporated into polyetheretherketone (PEEK) polymer matrix ranged from 15 to 30 vol% and the composites were successfully fabricated by compression molding technique. This study presents the mechanical properties and in vitro human osteoblast-like cell (MG-63) response of the composite material developed. The bending modulus and strength of Sr-HA/PEEK composites were tailored to mimic human cortical bone. PEEK reinforced with 25 and 30 vol% Sr-HA exhibited bending modulus of 9.6 and 10.6 GPa, respectively; alternatively, the bending strengths of the composites were 93.8 and 89.1 MPa, respectively. Based on the qualitative comparison of apatite formation in SBF and quantitative measurement of MG-63-mediated mineralization in vitro, the Sr-HA/PEEK composite was proven to outperform HA/PEEK in providing bioactivity. However, no difference was found in the trend of cell proliferation and alkaline phosphatase activity between different composites. Strontium, in the form of strontium-containing hydroxyapatite (Sr-HA), was confirmed to enhance bioactivity in the PEEK composites. © 2009 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/143138
ISSN
0142-9612
2023 Impact Factor: 12.8
2023 SCImago Journal Rankings: 3.016
ISI Accession Number ID
WOS:000267469300002
Funding AgencyGrant Number
ITC
RGC
Hong Kong Government
Funding Information:

This work was supported by funds from ITC and RGC, Hong Kong Government. We thank the Electron Microscope Unit, HKU for the use and technical support of SEM and TEM facilities.

References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorWong, KLen_HK
dc.contributor.authorWong, CTen_HK
dc.contributor.authorLiu, WCen_HK
dc.contributor.authorPan, HBen_HK
dc.contributor.authorFong, MKen_HK
dc.contributor.authorLam, WMen_HK
dc.contributor.authorCheung, WLen_HK
dc.contributor.authorTang, WMen_HK
dc.contributor.authorChiu, KYen_HK
dc.contributor.authorLuk, KDKen_HK
dc.contributor.authorLu, WWen_HK
dc.date.accessioned2011-11-02T03:06:16Z-
dc.date.available2011-11-02T03:06:16Z-
dc.date.issued2009en_HK
dc.identifier.citationBiomaterials, 2009, v. 30 n. 23-24, p. 3810-3817en_HK
dc.identifier.issn0142-9612en_HK
dc.identifier.urihttp://hdl.handle.net/10722/143138-
dc.description.abstractStrontium-containing hydroxyapatite/polyetheretherketone (Sr-HA/PEEK) composites were developed as alternative materials for load-bearing orthopaedic applications. The amount of strontium-containing hydroxyapatite (Sr-HA) incorporated into polyetheretherketone (PEEK) polymer matrix ranged from 15 to 30 vol% and the composites were successfully fabricated by compression molding technique. This study presents the mechanical properties and in vitro human osteoblast-like cell (MG-63) response of the composite material developed. The bending modulus and strength of Sr-HA/PEEK composites were tailored to mimic human cortical bone. PEEK reinforced with 25 and 30 vol% Sr-HA exhibited bending modulus of 9.6 and 10.6 GPa, respectively; alternatively, the bending strengths of the composites were 93.8 and 89.1 MPa, respectively. Based on the qualitative comparison of apatite formation in SBF and quantitative measurement of MG-63-mediated mineralization in vitro, the Sr-HA/PEEK composite was proven to outperform HA/PEEK in providing bioactivity. However, no difference was found in the trend of cell proliferation and alkaline phosphatase activity between different composites. Strontium, in the form of strontium-containing hydroxyapatite (Sr-HA), was confirmed to enhance bioactivity in the PEEK composites. © 2009 Elsevier Ltd. All rights reserved.en_HK
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/biomaterialsen_HK
dc.relation.ispartofBiomaterialsen_HK
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication in <Journal title>. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in PUBLICATION, [VOL#, ISSUE#, (DATE)] DOI#-
dc.subjectBioactivityen_HK
dc.subjectHydroxyapatiteen_HK
dc.subjectMechanicalen_HK
dc.subjectPolyetheretherketoneen_HK
dc.subjectStrontiumen_HK
dc.subject.meshAlkaline Phosphatase - metabolism-
dc.subject.meshBiocompatible Materials - chemistry - toxicity-
dc.subject.meshDurapatite - chemistry-
dc.subject.meshKetones - chemistry-
dc.subject.meshPolyethylene Glycols - chemistry-
dc.titleMechanical properties and in vitro response of strontium-containing hydroxyapatite/polyetheretherketone compositesen_HK
dc.typeArticleen_HK
dc.identifier.emailPan, HB:haobo@hku.hken_HK
dc.identifier.emailCheung, WL:wlcheung@hkucc.hku.hken_HK
dc.identifier.emailChiu, KY:pkychiu@hkucc.hku.hken_HK
dc.identifier.emailLuk, KDK:hcm21000@hku.hken_HK
dc.identifier.emailLu, WW:wwlu@hku.hken_HK
dc.identifier.authorityPan, HB=rp01564en_HK
dc.identifier.authorityCheung, WL=rp00103en_HK
dc.identifier.authorityChiu, KY=rp00379en_HK
dc.identifier.authorityLuk, KDK=rp00333en_HK
dc.identifier.authorityLu, WW=rp00411en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.biomaterials.2009.04.016en_HK
dc.identifier.pmid19427032-
dc.identifier.scopuseid_2-s2.0-67349241319en_HK
dc.identifier.hkuros180199-
dc.identifier.hkuros160633-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-67349241319&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume30en_HK
dc.identifier.issue23-24en_HK
dc.identifier.spage3810en_HK
dc.identifier.epage3817en_HK
dc.identifier.eissn1878-5905-
dc.identifier.isiWOS:000267469300002-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridWong, KL=24460004600en_HK
dc.identifier.scopusauthoridWong, CT=7404954512en_HK
dc.identifier.scopusauthoridLiu, WC=26656769100en_HK
dc.identifier.scopusauthoridPan, HB=7403295092en_HK
dc.identifier.scopusauthoridFong, MK=26538502500en_HK
dc.identifier.scopusauthoridLam, WM=13403256300en_HK
dc.identifier.scopusauthoridCheung, WL=7202743084en_HK
dc.identifier.scopusauthoridTang, WM=7403430820en_HK
dc.identifier.scopusauthoridChiu, KY=7202988127en_HK
dc.identifier.scopusauthoridLuk, KDK=7201921573en_HK
dc.identifier.scopusauthoridLu, WW=7404215221en_HK
dc.identifier.issnl0142-9612-

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