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Article: Death And Proliferation Of Chondrocytes In The Degraded Mandibular Condylar Cartilage Of Rats Induced By Experimentally Created Disordered Occlusion.

TitleDeath And Proliferation Of Chondrocytes In The Degraded Mandibular Condylar Cartilage Of Rats Induced By Experimentally Created Disordered Occlusion.
Authors
KeywordsApoptosis
Cartilage
Osteoarthritis (OA)
Proliferation
Sex difference
Temporomandibular joint (TMJ)
Issue Date2009
Citation
Apoptosis : An International Journal On Programmed Cell Death, 2009, v. 14 n. 1, p. 22-30 How to Cite?
AbstractObjective: To Investigate The Effect Of Experimentally Created Disordered Occlusion (Ecdo) On Cell Death And Proliferation In Rat Mandibular Condylar Cartilage. Methods: Sprague-Dawley Rats Were Randomly Assigned To Experimental And Control Groups. In The Experimental Groups, Ecdo Was Created By The Dental Orthodontic Method. By Means Of Histological Evaluation, Immunohistochemistry And Tunel Staining, We Studied The Histomorphological Changes, The Death And Proliferation Of Chondrocytes. Results: Time- And Sex-Related Progressive Histologic Degradation Was Observed In The Condylar Cartilage Of Ecdo Rats, Accompanied With Diminished Chondrocyte Proliferation In The Female 12-Week Ecdo Subgroup (P < 0.05). An Increase In The Number Of Apoptotic Chondrocytes Was Seen In Both The Female 8- And 12-Week Ecdo Subgroups And In The Male Ecdo 12-Week Subgroup (All P < 0.05), But Not In The Male Ecdo 8-Week Subgroup (P > 0.05). Conclusion: Ecdo Induces Degradation In The Rat Condylar Cartilage Accompanied By An Increase In Chondrocyte Death.
Persistent Identifierhttp://hdl.handle.net/10722/144267
ISSN
2023 Impact Factor: 6.1
2023 SCImago Journal Rankings: 1.427
ISI Accession Number ID
Funding AgencyGrant Number
National Natural Science Foundation of China
30471909
30772429
Funding Information:

This study was supported by grants from the National Natural Science Foundation of China (No. 30471909 and No. 30772429). The authors thank Dr. Qing. Li for her valuable comments, and thank Dr. Yongyong Xu for his assistance in statistical analysis.

 

DC FieldValueLanguage
dc.contributor.authorJiao, Ken_US
dc.contributor.authorWang, MQen_US
dc.contributor.authorNiu, LNen_US
dc.contributor.authorDai, Jen_US
dc.contributor.authorYu, SBen_US
dc.contributor.authorLiu, XDen_US
dc.contributor.authorWang, GWen_US
dc.date.accessioned2012-01-20T08:58:31Z-
dc.date.available2012-01-20T08:58:31Z-
dc.date.issued2009en_US
dc.identifier.citationApoptosis : An International Journal On Programmed Cell Death, 2009, v. 14 n. 1, p. 22-30en_US
dc.identifier.issn1573-675Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/144267-
dc.description.abstractObjective: To Investigate The Effect Of Experimentally Created Disordered Occlusion (Ecdo) On Cell Death And Proliferation In Rat Mandibular Condylar Cartilage. Methods: Sprague-Dawley Rats Were Randomly Assigned To Experimental And Control Groups. In The Experimental Groups, Ecdo Was Created By The Dental Orthodontic Method. By Means Of Histological Evaluation, Immunohistochemistry And Tunel Staining, We Studied The Histomorphological Changes, The Death And Proliferation Of Chondrocytes. Results: Time- And Sex-Related Progressive Histologic Degradation Was Observed In The Condylar Cartilage Of Ecdo Rats, Accompanied With Diminished Chondrocyte Proliferation In The Female 12-Week Ecdo Subgroup (P < 0.05). An Increase In The Number Of Apoptotic Chondrocytes Was Seen In Both The Female 8- And 12-Week Ecdo Subgroups And In The Male Ecdo 12-Week Subgroup (All P < 0.05), But Not In The Male Ecdo 8-Week Subgroup (P > 0.05). Conclusion: Ecdo Induces Degradation In The Rat Condylar Cartilage Accompanied By An Increase In Chondrocyte Death.en_US
dc.languageengen_US
dc.relation.ispartofApoptosis : An International Journal On Programmed Cell Deathen_US
dc.subjectApoptosis-
dc.subjectCartilage-
dc.subjectOsteoarthritis (OA)-
dc.subjectProliferation-
dc.subjectSex difference-
dc.subjectTemporomandibular joint (TMJ)-
dc.titleDeath And Proliferation Of Chondrocytes In The Degraded Mandibular Condylar Cartilage Of Rats Induced By Experimentally Created Disordered Occlusion.en_US
dc.typeArticleen_US
dc.identifier.authorityDai, J=rp01569en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s10495-008-0279-5en_US
dc.identifier.pmid19052875-
dc.identifier.scopuseid_2-s2.0-58949100147en_US
dc.identifier.volume14en_US
dc.identifier.issue1en_US
dc.identifier.spage22en_US
dc.identifier.epage30en_US
dc.identifier.isiWOS:000261954700002-
dc.identifier.citeulike3762608-
dc.identifier.issnl1360-8185-

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