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Article: Diabetes, body mass index and the excess risk of coronary heart disease, ischemic and hemorrhagic stroke in the Asia Pacific Cohort Studies Collaboration

TitleDiabetes, body mass index and the excess risk of coronary heart disease, ischemic and hemorrhagic stroke in the Asia Pacific Cohort Studies Collaboration
Authors
KeywordsBody mass index
Cardiovascular disease
Coronary heart disease
Diabetes
Effect modification
Pooled analysis
Stroke
Issue Date2012
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ypmed
Citation
Preventive Medicine, 2012, v. 54 n. 1, p. 38-41 How to Cite?
AbstractObjective: To examine the effects of diabetes on coronary heart disease, ischemic and hemorrhagic stroke and cardiovascular disease according to category of body mass index. Methods: Data on 161,161 men and women from 31 cohorts (baseline years, 1966-99; mean follow-up, 2-24. years) from the Asia Pacific Cohort Studies Collaboration were analyzed using Cox regression, stratified by sex and study and adjusted for age, systolic blood pressure and smoking. Diabetes was self-reported in all but one study. Body mass index was divided into five categories according to the World Health Organization Asian criteria. Results: The hazard ratio (diabetes v. not) for cardiovascular disease was 1.83 (95% confidence interval, 1.66-2.01). Across body mass index categories, this hazard ratio did not change significantly (p = 0.19). Similar lack of difference across body mass index groups was found for coronary heart disease (p = 0.33), ischemic stroke (p = 0.97) and hemorrhagic stroke (p = 0.98). Conclusions: Body mass index does not modify the effect of diabetes on major cardiovascular outcomes. © 2011.
Persistent Identifierhttp://hdl.handle.net/10722/144612
ISSN
2021 Impact Factor: 4.637
2020 SCImago Journal Rankings: 1.628
ISI Accession Number ID
Funding AgencyGrant Number
National Health and Medical Research Council of Australia571281
Bunyu Life Science Foundation International
Funding Information:

This work was supported by the National Health and Medical Research Council of Australia's program grant 571281. YM was supported by the Bunyu Fellowship Program sponsored by Bunyu Life Science Foundation International.

References

 

DC FieldValueLanguage
dc.contributor.authorMurakami, Yen_HK
dc.contributor.authorHuxley, RRen_HK
dc.contributor.authorLam, THen_HK
dc.contributor.authorTsukinoki, Ren_HK
dc.contributor.authorFang, Xen_HK
dc.contributor.authorKim, HCen_HK
dc.contributor.authorWoodward, Men_HK
dc.contributor.authorAsia Pacific Cohort Studies Collaboration-
dc.date.accessioned2012-02-03T06:15:45Z-
dc.date.available2012-02-03T06:15:45Z-
dc.date.issued2012en_HK
dc.identifier.citationPreventive Medicine, 2012, v. 54 n. 1, p. 38-41en_HK
dc.identifier.issn0091-7435en_HK
dc.identifier.urihttp://hdl.handle.net/10722/144612-
dc.description.abstractObjective: To examine the effects of diabetes on coronary heart disease, ischemic and hemorrhagic stroke and cardiovascular disease according to category of body mass index. Methods: Data on 161,161 men and women from 31 cohorts (baseline years, 1966-99; mean follow-up, 2-24. years) from the Asia Pacific Cohort Studies Collaboration were analyzed using Cox regression, stratified by sex and study and adjusted for age, systolic blood pressure and smoking. Diabetes was self-reported in all but one study. Body mass index was divided into five categories according to the World Health Organization Asian criteria. Results: The hazard ratio (diabetes v. not) for cardiovascular disease was 1.83 (95% confidence interval, 1.66-2.01). Across body mass index categories, this hazard ratio did not change significantly (p = 0.19). Similar lack of difference across body mass index groups was found for coronary heart disease (p = 0.33), ischemic stroke (p = 0.97) and hemorrhagic stroke (p = 0.98). Conclusions: Body mass index does not modify the effect of diabetes on major cardiovascular outcomes. © 2011.en_HK
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ypmeden_HK
dc.relation.ispartofPreventive Medicineen_HK
dc.subjectBody mass indexen_HK
dc.subjectCardiovascular diseaseen_HK
dc.subjectCoronary heart diseaseen_HK
dc.subjectDiabetesen_HK
dc.subjectEffect modificationen_HK
dc.subjectPooled analysisen_HK
dc.subjectStrokeen_HK
dc.titleDiabetes, body mass index and the excess risk of coronary heart disease, ischemic and hemorrhagic stroke in the Asia Pacific Cohort Studies Collaborationen_HK
dc.typeArticleen_HK
dc.identifier.emailLam, TH:hrmrlth@hkucc.hku.hken_HK
dc.identifier.authorityLam, TH=rp00326en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ypmed.2011.10.010en_HK
dc.identifier.pmid22056629-
dc.identifier.scopuseid_2-s2.0-84855490908en_HK
dc.identifier.hkuros198565en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84855490908&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume54en_HK
dc.identifier.issue1en_HK
dc.identifier.spage38en_HK
dc.identifier.epage41en_HK
dc.identifier.isiWOS:000299455500010-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridMurakami, Y=15755641300en_HK
dc.identifier.scopusauthoridHuxley, RR=6701828350en_HK
dc.identifier.scopusauthoridLam, TH=7202522876en_HK
dc.identifier.scopusauthoridTsukinoki, R=16044251500en_HK
dc.identifier.scopusauthoridFang, X=7401433142en_HK
dc.identifier.scopusauthoridKim, HC=53984510300en_HK
dc.identifier.scopusauthoridWoodward, M=7102510958en_HK
dc.identifier.citeulike9962567-
dc.identifier.issnl0091-7435-

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