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Article: A simple bias correction in linear regression for quantitative trait association under two-tail extreme selection

TitleA simple bias correction in linear regression for quantitative trait association under two-tail extreme selection
Authors
Kwan, JSHKung, AWCSham, PC
KeywordsBias correction
Extreme selection
Linear regression
QTL association
Selective genotyping
Issue Date2011
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0001-8244
Citation
Behavior Genetics, 2011, v. 41 n. 5, p. 776-779 How to Cite?
DOI: http://dx.doi.org/10.1007/s10519-011-9475-0
AbstractSelective genotyping can increase power in quantitative trait association. One example of selective genotyping is two-tail extreme selection, but simple linear regression analysis gives a biased genetic effect estimate. Here, we present a simple correction for the bias. © The Author(s) 2011.
Persistent Identifierhttp://hdl.handle.net/10722/145096
ISSN
0001-8244
2021 Impact Factor: 2.965
2020 SCImago Journal Rankings: 0.865
PubMed Central ID
PMC3162965
ISI Accession Number ID
WOS:000294297200016
Funding AgencyGrant Number
Hong Kong Research Grants Council GRF HKU774707
University of Hong Kong Strategic Research Theme on Genomics
European CommunityHEALTH-F2-2010-241909
Funding Information:

This work was funded by Hong Kong Research Grants Council GRF HKU 774707, and The University of Hong Kong Strategic Research Theme on Genomics, and the European Community's Seventh Framework Programme under grant agreement No. HEALTH-F2-2010-241909 (Project EU-GEI).

References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorKwan, JSHen_HK
dc.contributor.authorKung, AWCen_HK
dc.contributor.authorSham, PCen_HK
dc.date.accessioned2012-02-21T05:44:48Z-
dc.date.available2012-02-21T05:44:48Z-
dc.date.issued2011en_HK
dc.identifier.citationBehavior Genetics, 2011, v. 41 n. 5, p. 776-779en_HK
dc.identifier.issn0001-8244en_HK
dc.identifier.urihttp://hdl.handle.net/10722/145096-
dc.description.abstractSelective genotyping can increase power in quantitative trait association. One example of selective genotyping is two-tail extreme selection, but simple linear regression analysis gives a biased genetic effect estimate. Here, we present a simple correction for the bias. © The Author(s) 2011.en_HK
dc.languageengen_US
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0001-8244en_HK
dc.relation.ispartofBehavior Geneticsen_HK
dc.rightsThe Author(s)en_US
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.en_US
dc.subjectBias correctionen_HK
dc.subjectExtreme selectionen_HK
dc.subjectLinear regressionen_HK
dc.subjectQTL associationen_HK
dc.subjectSelective genotypingen_HK
dc.titleA simple bias correction in linear regression for quantitative trait association under two-tail extreme selectionen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4551/resserv?sid=springerlink&genre=article&atitle=A Simple Bias Correction in Linear Regression for Quantitative Trait Association Under Two-Tail Extreme Selection&title=Behavior Genetics&issn=00018244&date=2011-09-01&volume=41&issue=5& spage=776&authors=Johnny S. H. Kwan, Annie W. C. Kung, Pak C. Shamen_US
dc.identifier.emailKung, AWC: awckung@hku.hken_HK
dc.identifier.emailSham, PC: pcsham@hku.hken_HK
dc.identifier.authorityKung, AWC=rp00368en_HK
dc.identifier.authoritySham, PC=rp00459en_HK
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1007/s10519-011-9475-0en_HK
dc.identifier.pmid21626281-
dc.identifier.pmcidPMC3162965-
dc.identifier.scopuseid_2-s2.0-80054865366en_HK
dc.identifier.hkuros186061-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80054865366&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume41en_HK
dc.identifier.issue5en_HK
dc.identifier.spage776en_HK
dc.identifier.epage779en_HK
dc.identifier.eissn1573-3297en_US
dc.identifier.isiWOS:000294297200016-
dc.publisher.placeUnited Statesen_HK
dc.description.otherSpringer Open Choice, 21 Feb 2012en_US
dc.identifier.scopusauthoridKwan, JSH=37063349600en_HK
dc.identifier.scopusauthoridKung, AWC=7102322339en_HK
dc.identifier.scopusauthoridSham, PC=34573429300en_HK
dc.identifier.citeulike9410670-
dc.identifier.issnl0001-8244-

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