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Article: Clinicopathological correlation of epiretinal membranes and posterior lens opacification following perfluorohexyloctane tamponade

TitleClinicopathological correlation of epiretinal membranes and posterior lens opacification following perfluorohexyloctane tamponade
Authors
Issue Date2001
PublisherBMJ Publishing Group. The Journal's web site is located at http://bjo.bmjjournals.com/
Citation
British Journal Of Ophthalmology, 2001, v. 85 n. 2, p. 179-183 How to Cite?
AbstractBackground/aims - Epiretinal and retrolental proliferation may occur during prolonged use of the novel tamponade agent perfluorohexyloctane (F 6H 8). This study aims to determine whether there is any histological evidence that F 6H 8 has a role in the formation of these membranes. Methods - Eight epiretinal membranes and three opaque posterior lens capsules were excised from patients in whom F 6H 8 had been used as a long term retinal tamponade agent. The membranes and capsules were examined employing light microscopic methods, including immunohistochemistry. Results - The epiretinal membranes showed histological features typical of proliferative vitreoretinopathy (PVR) epiretinal membranes, but they also exhibited a dense macrophagic infiltration. In addition, three of the membranes contained multinucleated cells. Macrophages represented up to 30% of the cells present and appeared to contain large intracytoplasmic vacuoles. Similar cells were seen on the back of the posterior lens capsule in one specimen and all three capsules had posterior migration of lens epithelium. Conclusion - The pathological findings are not simply those of PVR. The macrophage infiltration suggests that there may be a biological reaction to F 6H 8 which could reflect its surmised propensity to emulsify. Further investigations concerning the cellular response to this promising tamponade agent are warranted.
Persistent Identifierhttp://hdl.handle.net/10722/146260
ISSN
2023 Impact Factor: 3.7
2023 SCImago Journal Rankings: 1.862
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHiscott, Pen_HK
dc.contributor.authorMagee, RMen_HK
dc.contributor.authorColthurst, Men_HK
dc.contributor.authorLois, Nen_HK
dc.contributor.authorWong, Den_HK
dc.date.accessioned2012-04-10T01:49:46Z-
dc.date.available2012-04-10T01:49:46Z-
dc.date.issued2001en_HK
dc.identifier.citationBritish Journal Of Ophthalmology, 2001, v. 85 n. 2, p. 179-183en_HK
dc.identifier.issn0007-1161en_HK
dc.identifier.urihttp://hdl.handle.net/10722/146260-
dc.description.abstractBackground/aims - Epiretinal and retrolental proliferation may occur during prolonged use of the novel tamponade agent perfluorohexyloctane (F 6H 8). This study aims to determine whether there is any histological evidence that F 6H 8 has a role in the formation of these membranes. Methods - Eight epiretinal membranes and three opaque posterior lens capsules were excised from patients in whom F 6H 8 had been used as a long term retinal tamponade agent. The membranes and capsules were examined employing light microscopic methods, including immunohistochemistry. Results - The epiretinal membranes showed histological features typical of proliferative vitreoretinopathy (PVR) epiretinal membranes, but they also exhibited a dense macrophagic infiltration. In addition, three of the membranes contained multinucleated cells. Macrophages represented up to 30% of the cells present and appeared to contain large intracytoplasmic vacuoles. Similar cells were seen on the back of the posterior lens capsule in one specimen and all three capsules had posterior migration of lens epithelium. Conclusion - The pathological findings are not simply those of PVR. The macrophage infiltration suggests that there may be a biological reaction to F 6H 8 which could reflect its surmised propensity to emulsify. Further investigations concerning the cellular response to this promising tamponade agent are warranted.en_HK
dc.languageengen_US
dc.publisherBMJ Publishing Group. The Journal's web site is located at http://bjo.bmjjournals.com/en_HK
dc.relation.ispartofBritish Journal of Ophthalmologyen_HK
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshCataract - Chemically Induced - Pathologyen_US
dc.subject.meshEpiretinal Membrane - Chemically Induced - Pathologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshFluorocarbons - Adverse Effects - Therapeutic Useen_US
dc.subject.meshHumansen_US
dc.subject.meshMacrophages - Pathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPressureen_US
dc.subject.meshRecurrenceen_US
dc.subject.meshRetinal Detachment - Therapyen_US
dc.subject.meshVitreoretinopathy, Proliferative - Pathology - Surgeryen_US
dc.titleClinicopathological correlation of epiretinal membranes and posterior lens opacification following perfluorohexyloctane tamponadeen_HK
dc.typeArticleen_HK
dc.identifier.emailWong, D: shdwong@hku.hken_HK
dc.identifier.authorityWong, D=rp00516en_HK
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1136/bjo.85.2.179en_HK
dc.identifier.pmid11159482-
dc.identifier.pmcidPMC1723852-
dc.identifier.scopuseid_2-s2.0-0035130559en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035130559&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume85en_HK
dc.identifier.issue2en_HK
dc.identifier.spage179en_HK
dc.identifier.epage183en_HK
dc.identifier.isiWOS:000166722500014-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridHiscott, P=7006368693en_HK
dc.identifier.scopusauthoridMagee, RM=14820645000en_HK
dc.identifier.scopusauthoridColthurst, M=36955353400en_HK
dc.identifier.scopusauthoridLois, N=7003969757en_HK
dc.identifier.scopusauthoridWong, D=7401536078en_HK
dc.identifier.issnl0007-1161-

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