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- Publisher Website: 10.3109/07357900903286925
- Scopus: eid_2-s2.0-77952127407
- PMID: 20210524
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Article: Glutathione-s-transferase-pi expression in early breast cancer: Association with outcome and response to chemotherapy
Title | Glutathione-s-transferase-pi expression in early breast cancer: Association with outcome and response to chemotherapy |
---|---|
Authors | |
Keywords | Breast cancer Chemotherapy Lutathione-S-transferase-pi Prognosis and response predictions |
Issue Date | 2010 |
Publisher | Informa Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/07357907.asp |
Citation | Cancer Investigation, 2010, v. 28 n. 5, p. 554-559 How to Cite? |
Abstract | Glutathione-S-transferase-pi (GST-pi) is a detoxification enzyme expressed in breast cancer; however its involvement in chemotherapy sensitivity and prognosis is not well understood. We evaluated the expression of GSTpi and its predictive role of chemotherapy response. Breast tumor samples from 166 patients at stage I/II of the disease were immunostained for GST-pi, and the expression was 96 . There was a trend toward improved disease-free survival with high GST-pi expression (p =.09). There was a statistically non-significant association between high GST-pi expression and improved outcome with adjuvant chemotherapy (p= .055). Further studies should evaluate the role of GST-pi expression in relation to response to different chemotherapies. Copyright © 2010 Informa Healthcare USA, Inc. |
Persistent Identifier | http://hdl.handle.net/10722/146596 |
ISSN | 2023 Impact Factor: 1.8 2023 SCImago Journal Rankings: 0.604 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Arun, BK | en_HK |
dc.contributor.author | Granville, LA | en_HK |
dc.contributor.author | Yin, G | en_HK |
dc.contributor.author | Middleton, LP | en_HK |
dc.contributor.author | Dawood, S | en_HK |
dc.contributor.author | Kau, SW | en_HK |
dc.contributor.author | Kamal, A | en_HK |
dc.contributor.author | Hsu, L | en_HK |
dc.contributor.author | Hortobagyi, GN | en_HK |
dc.contributor.author | Sahin, AA | en_HK |
dc.date.accessioned | 2012-05-02T08:37:18Z | - |
dc.date.available | 2012-05-02T08:37:18Z | - |
dc.date.issued | 2010 | en_HK |
dc.identifier.citation | Cancer Investigation, 2010, v. 28 n. 5, p. 554-559 | en_HK |
dc.identifier.issn | 0735-7907 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/146596 | - |
dc.description.abstract | Glutathione-S-transferase-pi (GST-pi) is a detoxification enzyme expressed in breast cancer; however its involvement in chemotherapy sensitivity and prognosis is not well understood. We evaluated the expression of GSTpi and its predictive role of chemotherapy response. Breast tumor samples from 166 patients at stage I/II of the disease were immunostained for GST-pi, and the expression was 96 . There was a trend toward improved disease-free survival with high GST-pi expression (p =.09). There was a statistically non-significant association between high GST-pi expression and improved outcome with adjuvant chemotherapy (p= .055). Further studies should evaluate the role of GST-pi expression in relation to response to different chemotherapies. Copyright © 2010 Informa Healthcare USA, Inc. | en_HK |
dc.language | eng | en_US |
dc.publisher | Informa Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/07357907.asp | en_HK |
dc.relation.ispartof | Cancer Investigation | en_HK |
dc.subject | Breast cancer | en_HK |
dc.subject | Chemotherapy | en_HK |
dc.subject | Lutathione-S-transferase-pi | en_HK |
dc.subject | Prognosis and response predictions | en_HK |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Aged | en_US |
dc.subject.mesh | Aged, 80 And Over | en_US |
dc.subject.mesh | Anthracyclines - Therapeutic Use | en_US |
dc.subject.mesh | Antineoplastic Agents - Therapeutic Use | en_US |
dc.subject.mesh | Breast Neoplasms - Drug Therapy - Enzymology | en_US |
dc.subject.mesh | Bridged Compounds - Therapeutic Use | en_US |
dc.subject.mesh | Chemotherapy, Adjuvant | en_US |
dc.subject.mesh | Combined Modality Therapy | en_US |
dc.subject.mesh | Disease-Free Survival | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Glutathione S-Transferase Pi - Metabolism | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Middle Aged | en_US |
dc.subject.mesh | Neoplasms, Hormone-Dependent - Drug Therapy - Enzymology | en_US |
dc.subject.mesh | Prognosis | en_US |
dc.subject.mesh | Taxoids - Therapeutic Use | en_US |
dc.title | Glutathione-s-transferase-pi expression in early breast cancer: Association with outcome and response to chemotherapy | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Yin, G: gyin@hku.hk | en_HK |
dc.identifier.authority | Yin, G=rp00831 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.3109/07357900903286925 | en_HK |
dc.identifier.pmid | 20210524 | - |
dc.identifier.scopus | eid_2-s2.0-77952127407 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-77952127407&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 28 | en_HK |
dc.identifier.issue | 5 | en_HK |
dc.identifier.spage | 554 | en_HK |
dc.identifier.epage | 559 | en_HK |
dc.identifier.isi | WOS:000278739700015 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Arun, BK=6603689664 | en_HK |
dc.identifier.scopusauthorid | Granville, LA=6701779041 | en_HK |
dc.identifier.scopusauthorid | Yin, G=8725807500 | en_HK |
dc.identifier.scopusauthorid | Middleton, LP=7005171424 | en_HK |
dc.identifier.scopusauthorid | Dawood, S=16042124400 | en_HK |
dc.identifier.scopusauthorid | Kau, SW=7005363979 | en_HK |
dc.identifier.scopusauthorid | Kamal, A=15122143800 | en_HK |
dc.identifier.scopusauthorid | Hsu, L=8280360600 | en_HK |
dc.identifier.scopusauthorid | Hortobagyi, GN=7202399346 | en_HK |
dc.identifier.scopusauthorid | Sahin, AA=7202605028 | en_HK |
dc.identifier.issnl | 0735-7907 | - |