File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Effect of platelet-rich plasma on a rabbit model of nicotine-compromised bone healing

TitleEffect of platelet-rich plasma on a rabbit model of nicotine-compromised bone healing
Authors
Ma, LZheng, LWSham, MHLam, CKZwahlen, RACheung, LK
Issue Date2011
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/joms
Citation
Journal Of Oral And Maxillofacial Surgery, 2011, v. 69 n. 1, p. 28-35 How to Cite?
DOI: http://dx.doi.org/10.1016/j.joms.2010.05.007
AbstractPurpose: This study aimed to evaluate the effects of platelet-rich plasma (PRP) on nicotine-compromised bone healing. Materials and Methods: Fifteen adult New Zealand white rabbits were implanted with 1.5-g time-release nicotine pellets. Bilateral mandibular distraction osteogenesis was then performed. Autologous PRP was injected into 1 side of the distraction regenerate, whereas physiologic saline solution was injected into the contralateral side as a control. Five rabbits were killed on day 5 of active distraction, on day 11 of active distraction, and in week 2 of consolidation, respectively. Results: In the PRP the platelet enrichment was 14.63 ± 3.081fold of that in whole blood. Plain radiography and microcomputed tomography assessment showed no significant difference between the PRP injection and control sides. Histologic examination showed more disorganized distraction tissue on the PRP injection side. Conclusions: PRP injection at an early stage of active distraction does not significantly enhance bone healing in the nicotine-compromised rabbit model of mandibular lengthening. © 2011 American Association of Oral and Maxillofacial Surgeons.
Persistent Identifierhttp://hdl.handle.net/10722/147624
ISSN
0278-2391
2021 Impact Factor: 2.136
2020 SCImago Journal Rankings: 0.752
ISI Accession Number ID
WOS:000286017200004
Funding AgencyGrant Number
University of Hong KongHKU200507176099
Funding Information:

Supported by the Small Project Funding Programme (reference code HKU200507176099) from The University of Hong Kong.

References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorMa, Len_HK
dc.contributor.authorZheng, LWen_HK
dc.contributor.authorSham, MHen_HK
dc.contributor.authorLam, CKen_HK
dc.contributor.authorZwahlen, RAen_HK
dc.contributor.authorCheung, LKen_HK
dc.date.accessioned2012-05-29T06:05:03Z-
dc.date.available2012-05-29T06:05:03Z-
dc.date.issued2011en_HK
dc.identifier.citationJournal Of Oral And Maxillofacial Surgery, 2011, v. 69 n. 1, p. 28-35en_HK
dc.identifier.issn0278-2391en_HK
dc.identifier.urihttp://hdl.handle.net/10722/147624-
dc.description.abstractPurpose: This study aimed to evaluate the effects of platelet-rich plasma (PRP) on nicotine-compromised bone healing. Materials and Methods: Fifteen adult New Zealand white rabbits were implanted with 1.5-g time-release nicotine pellets. Bilateral mandibular distraction osteogenesis was then performed. Autologous PRP was injected into 1 side of the distraction regenerate, whereas physiologic saline solution was injected into the contralateral side as a control. Five rabbits were killed on day 5 of active distraction, on day 11 of active distraction, and in week 2 of consolidation, respectively. Results: In the PRP the platelet enrichment was 14.63 ± 3.081fold of that in whole blood. Plain radiography and microcomputed tomography assessment showed no significant difference between the PRP injection and control sides. Histologic examination showed more disorganized distraction tissue on the PRP injection side. Conclusions: PRP injection at an early stage of active distraction does not significantly enhance bone healing in the nicotine-compromised rabbit model of mandibular lengthening. © 2011 American Association of Oral and Maxillofacial Surgeons.en_HK
dc.languageengen_US
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/jomsen_HK
dc.relation.ispartofJournal of Oral and Maxillofacial Surgeryen_HK
dc.subject.meshAnimalsen_US
dc.subject.meshBone Regeneration - Drug Effectsen_US
dc.subject.meshConnective Tissue - Drug Effects - Pathologyen_US
dc.subject.meshDelayed-Action Preparationsen_US
dc.subject.meshDisease Models, Animalen_US
dc.subject.meshMandible - Drug Effects - Radiography - Surgeryen_US
dc.subject.meshNicotine - Adverse Effectsen_US
dc.subject.meshNicotinic Agonists - Adverse Effectsen_US
dc.subject.meshOsteogenesis - Drug Effectsen_US
dc.subject.meshOsteogenesis, Distraction - Methodsen_US
dc.subject.meshOsteotomy - Methodsen_US
dc.subject.meshPlatelet Counten_US
dc.subject.meshPlatelet-Rich Plasma - Physiologyen_US
dc.subject.meshRabbitsen_US
dc.subject.meshTime Factorsen_US
dc.subject.meshTransforming Growth Factor Beta1 - Analysisen_US
dc.subject.meshWound Healing - Drug Effectsen_US
dc.subject.meshX-Ray Microtomographyen_US
dc.titleEffect of platelet-rich plasma on a rabbit model of nicotine-compromised bone healingen_HK
dc.typeArticleen_HK
dc.identifier.emailZheng, LW:lwzheng@hku.hken_HK
dc.identifier.emailSham, MH:mhsham@hkucc.hku.hken_HK
dc.identifier.emailZwahlen, RA:zwahlen@hku.hken_HK
dc.identifier.emailCheung, LK:lkcheung@hkucc.hku.hken_HK
dc.identifier.authorityZheng, LW=rp01411en_HK
dc.identifier.authoritySham, MH=rp00380en_HK
dc.identifier.authorityZwahlen, RA=rp00055en_HK
dc.identifier.authorityCheung, LK=rp00013en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.joms.2010.05.007en_HK
dc.identifier.pmid20971543-
dc.identifier.scopuseid_2-s2.0-78650273546en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78650273546&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume69en_HK
dc.identifier.issue1en_HK
dc.identifier.spage28en_HK
dc.identifier.epage35en_HK
dc.identifier.isiWOS:000286017200004-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridMa, L=36072648200en_HK
dc.identifier.scopusauthoridZheng, LW=11241247300en_HK
dc.identifier.scopusauthoridSham, MH=7003729109en_HK
dc.identifier.scopusauthoridLam, CK=7402990801en_HK
dc.identifier.scopusauthoridZwahlen, RA=7004217269en_HK
dc.identifier.scopusauthoridCheung, LK=7102302747en_HK
dc.identifier.issnl0278-2391-

Export via OAI-PMH Interface in XML Formats

OR

Export to Other Non-XML Formats