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- Publisher Website: 10.1016/j.ocl.2011.07.012
- Scopus: eid_2-s2.0-80053178250
- PMID: 21944583
- WOS: WOS:000208681100002
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Article: Structure and Biology of the Intervertebral Disk in Health and Disease
Title | Structure and Biology of the Intervertebral Disk in Health and Disease |
---|---|
Authors | |
Keywords | Biology Degeneration Development Extracellular matrix Intervertebral disk |
Issue Date | 2011 |
Publisher | WB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/cort |
Citation | Orthopedic Clinics Of North America, 2011, v. 42 n. 4, p. 447-464 How to Cite? |
Abstract | The intervertebral disks along the spine provide motion and protection against mechanical loading. The 3 structural components, nucleus pulposus, annulus fibrosus, and cartilage endplate, function as a synergistic unit, though each has its own role. The cells within each of these components have distinct origins in development and morphology, producing specific extracellular matrix proteins that are organized into unique architectures fit for intervertebral disk function. This article focuses on various aspects of intervertebral disk biology and disruptions that could lead to diseases such as intervertebral disk degeneration. © 2011 Elsevier Inc. |
Persistent Identifier | http://hdl.handle.net/10722/147640 |
ISSN | 2021 Impact Factor: 2.771 2020 SCImago Journal Rankings: 1.177 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chan, WCW | en_HK |
dc.contributor.author | Sze, KL | en_HK |
dc.contributor.author | Samartzis, D | en_HK |
dc.contributor.author | Leung, VYL | en_HK |
dc.contributor.author | Chan, D | en_HK |
dc.date.accessioned | 2012-05-29T06:05:09Z | - |
dc.date.available | 2012-05-29T06:05:09Z | - |
dc.date.issued | 2011 | en_HK |
dc.identifier.citation | Orthopedic Clinics Of North America, 2011, v. 42 n. 4, p. 447-464 | en_HK |
dc.identifier.issn | 0030-5898 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/147640 | - |
dc.description.abstract | The intervertebral disks along the spine provide motion and protection against mechanical loading. The 3 structural components, nucleus pulposus, annulus fibrosus, and cartilage endplate, function as a synergistic unit, though each has its own role. The cells within each of these components have distinct origins in development and morphology, producing specific extracellular matrix proteins that are organized into unique architectures fit for intervertebral disk function. This article focuses on various aspects of intervertebral disk biology and disruptions that could lead to diseases such as intervertebral disk degeneration. © 2011 Elsevier Inc. | en_HK |
dc.language | eng | en_US |
dc.publisher | WB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/cort | en_HK |
dc.relation.ispartof | Orthopedic Clinics of North America | en_HK |
dc.subject | Biology | en_HK |
dc.subject | Degeneration | en_HK |
dc.subject | Development | en_HK |
dc.subject | Extracellular matrix | en_HK |
dc.subject | Intervertebral disk | en_HK |
dc.subject.mesh | Cervical Vertebrae | en_US |
dc.subject.mesh | Cytokines - Metabolism | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Intervertebral Disc - Anatomy & Histology - Embryology - Physiology | en_US |
dc.subject.mesh | Intervertebral Disc Degeneration - Physiopathology | en_US |
dc.subject.mesh | Low Back Pain - Etiology - Physiopathology | en_US |
dc.subject.mesh | Lumbar Vertebrae | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Matrix Metalloproteinases - Metabolism | en_US |
dc.subject.mesh | Thoracic Vertebrae | en_US |
dc.title | Structure and Biology of the Intervertebral Disk in Health and Disease | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Samartzis, D: dspine@hku.hk | en_HK |
dc.identifier.email | Leung, VYL: vicleung@hku.hk | en_HK |
dc.identifier.email | Chan, D: chand@hkucc.hku.hk | en_HK |
dc.identifier.authority | Samartzis, D=rp01430 | en_HK |
dc.identifier.authority | Leung, VYL=rp01764 | en_HK |
dc.identifier.authority | Chan, D=rp00540 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/j.ocl.2011.07.012 | en_HK |
dc.identifier.pmid | 21944583 | - |
dc.identifier.scopus | eid_2-s2.0-80053178250 | en_HK |
dc.identifier.hkuros | 189124 | - |
dc.identifier.hkuros | 210477 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-80053178250&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 42 | en_HK |
dc.identifier.issue | 4 | en_HK |
dc.identifier.spage | 447 | en_HK |
dc.identifier.epage | 464 | en_HK |
dc.identifier.isi | WOS:000208681100002 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Chan, WCW=24545687600 | en_HK |
dc.identifier.scopusauthorid | Sze, KL=12779346400 | en_HK |
dc.identifier.scopusauthorid | Samartzis, D=34572771100 | en_HK |
dc.identifier.scopusauthorid | Leung, VYL=35337438900 | en_HK |
dc.identifier.scopusauthorid | Chan, D=7402216545 | en_HK |
dc.identifier.issnl | 0030-5898 | - |