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Article: Clonal rearrangement and expression of the T cell receptor β gene and involvement of the breakpoint cluster region in blast crisis of CGL

TitleClonal rearrangement and expression of the T cell receptor β gene and involvement of the breakpoint cluster region in blast crisis of CGL
Authors
Chan, LCFurley, AJFord, AM
Issue Date1986
PublisherAmerican Society of Hematology. The Journal's web site is located at http://bloodjournal.hematologylibrary.org/
Citation
Blood, 1986, v. 67 n. 2, p. 533-536 How to Cite?
AbstractA case of lymphoid blast crisis of Ph1-positive CGL is described in which the blast cells had an immature T cell phenotype, clonal rearrangement and expression of the T cell receptor β gene, and a rearrangement of the breakpoint cluster region (bcr) on chromosome 22. This case therefore provides definite evidence for transformation involving a common myeloid-T lineage progenitor, penetrance of the Ph1 molecular alteration into the T cell lineage, and clonal selection in blast crisis at the level of a committed T lineage precursor.
Persistent Identifierhttp://hdl.handle.net/10722/147773
ISSN
0006-4971
2023 Impact Factor: 21.0
2023 SCImago Journal Rankings: 5.272
ISI Accession Number ID
WOS:A1986AZK8500045

 

DC FieldValueLanguage
dc.contributor.authorChan, LCen_US
dc.contributor.authorFurley, AJen_US
dc.contributor.authorFord, AMen_US
dc.date.accessioned2012-05-29T06:09:09Z-
dc.date.available2012-05-29T06:09:09Z-
dc.date.issued1986en_US
dc.identifier.citationBlood, 1986, v. 67 n. 2, p. 533-536en_US
dc.identifier.issn0006-4971en_US
dc.identifier.urihttp://hdl.handle.net/10722/147773-
dc.description.abstractA case of lymphoid blast crisis of Ph1-positive CGL is described in which the blast cells had an immature T cell phenotype, clonal rearrangement and expression of the T cell receptor β gene, and a rearrangement of the breakpoint cluster region (bcr) on chromosome 22. This case therefore provides definite evidence for transformation involving a common myeloid-T lineage progenitor, penetrance of the Ph1 molecular alteration into the T cell lineage, and clonal selection in blast crisis at the level of a committed T lineage precursor.en_US
dc.languageengen_US
dc.publisherAmerican Society of Hematology. The Journal's web site is located at http://bloodjournal.hematologylibrary.org/en_US
dc.relation.ispartofBlooden_US
dc.subject.meshChromosome Mappingen_US
dc.subject.meshDna Restriction Enzymes - Diagnostic Useen_US
dc.subject.meshGenesen_US
dc.subject.meshHumansen_US
dc.subject.meshLeukemia, Myeloid - Geneticsen_US
dc.subject.meshMacromolecular Substancesen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNucleic Acid Hybridizationen_US
dc.subject.meshPhiladelphia Chromosomeen_US
dc.subject.meshReceptors, Antigen, T-Cell - Genetics - Immunologyen_US
dc.subject.meshRecombination, Geneticen_US
dc.subject.meshTranslocation, Geneticen_US
dc.titleClonal rearrangement and expression of the T cell receptor β gene and involvement of the breakpoint cluster region in blast crisis of CGLen_US
dc.typeArticleen_US
dc.identifier.emailChan, LC:chanlc@hkucc.hku.hken_US
dc.identifier.authorityChan, LC=rp00373en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid3002526-
dc.identifier.scopuseid_2-s2.0-0022622380en_US
dc.identifier.volume67en_US
dc.identifier.issue2en_US
dc.identifier.spage533en_US
dc.identifier.epage536en_US
dc.identifier.isiWOS:A1986AZK8500045-
dc.publisher.placeUnited Statesen_US
dc.identifier.issnl0006-4971-

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