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Article: Endoplasmic storage disease of liver: Characterization of intracytoplasmic hyaline inclusions

TitleEndoplasmic storage disease of liver: Characterization of intracytoplasmic hyaline inclusions
Authors
Ng, IOLLai, ECSWu, PC
Keywordscomplement
endoplasmic storage disease
fibrinogen
ground glass hepatocytes
intracytoplasmic hyaline inclusions
liver
Issue Date1989
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/HIS
Citation
Histopathology, 1989, v. 15 n. 5, p. 473-481 How to Cite?
DOI: http://dx.doi.org/10.1111/j.1365-2559.1989.tb01607.x
AbstractTwo cases of endoplasmic storage disease of liver are described. The liver tissue in each case showed numerous intracytoplasmic hyaline inclusions of varying sizes with formation of ground-glass hepatocytes. These inclusions were pale eosinophilic in hematoxylin and eosin stained sections, and were periodic acid-Schiff and HB(s)Ag negative. Immunoperoxidase studies revealed strong positivity for fibrinogen and complement components C3 and C4 in case 1 and exclusive positivity for fibronogen in case 2. On electron microscopy, the inclusions appeared as granular or fibrillar material within dilated cisternae of rough endoplasmic reticulum.
Persistent Identifierhttp://hdl.handle.net/10722/147840
ISSN
0309-0167
2021 Impact Factor: 7.778
2020 SCImago Journal Rankings: 1.626
ISI Accession Number ID
WOS:A1989AZ99100003

 

DC FieldValueLanguage
dc.contributor.authorNg, IOLen_US
dc.contributor.authorLai, ECSen_US
dc.contributor.authorWu, PCen_US
dc.date.accessioned2012-05-29T06:09:30Z-
dc.date.available2012-05-29T06:09:30Z-
dc.date.issued1989en_US
dc.identifier.citationHistopathology, 1989, v. 15 n. 5, p. 473-481en_US
dc.identifier.issn0309-0167en_US
dc.identifier.urihttp://hdl.handle.net/10722/147840-
dc.description.abstractTwo cases of endoplasmic storage disease of liver are described. The liver tissue in each case showed numerous intracytoplasmic hyaline inclusions of varying sizes with formation of ground-glass hepatocytes. These inclusions were pale eosinophilic in hematoxylin and eosin stained sections, and were periodic acid-Schiff and HB(s)Ag negative. Immunoperoxidase studies revealed strong positivity for fibrinogen and complement components C3 and C4 in case 1 and exclusive positivity for fibronogen in case 2. On electron microscopy, the inclusions appeared as granular or fibrillar material within dilated cisternae of rough endoplasmic reticulum.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/HISen_US
dc.relation.ispartofHistopathologyen_US
dc.subjectcomplement-
dc.subjectendoplasmic storage disease-
dc.subjectfibrinogen-
dc.subjectground glass hepatocytes-
dc.subjectintracytoplasmic hyaline inclusions-
dc.subjectliver-
dc.subject.meshAdulten_US
dc.subject.meshCarcinoma, Hepatocellular - Complicationsen_US
dc.subject.meshComplement C3 - Metabolismen_US
dc.subject.meshComplement C4 - Metabolismen_US
dc.subject.meshEndoplasmic Reticulum - Metabolism - Pathologyen_US
dc.subject.meshFibrinogen - Metabolismen_US
dc.subject.meshHepatitis B - Complicationsen_US
dc.subject.meshHumansen_US
dc.subject.meshHyalin - Metabolismen_US
dc.subject.meshInclusion Bodies - Immunology - Metabolism - Pathologyen_US
dc.subject.meshLiver Cirrhosis - Complicationsen_US
dc.subject.meshLiver Diseases - Immunology - Metabolism - Pathologyen_US
dc.subject.meshLiver Neoplasms - Complicationsen_US
dc.subject.meshMaleen_US
dc.titleEndoplasmic storage disease of liver: Characterization of intracytoplasmic hyaline inclusionsen_US
dc.typeArticleen_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1365-2559.1989.tb01607.x-
dc.identifier.pmid2480934-
dc.identifier.scopuseid_2-s2.0-0024454643en_US
dc.identifier.volume15en_US
dc.identifier.issue5en_US
dc.identifier.spage473en_US
dc.identifier.epage481en_US
dc.identifier.isiWOS:A1989AZ99100003-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.issnl0309-0167-

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