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Article: Latent sites of Epstein-Barr virus infection

TitleLatent sites of Epstein-Barr virus infection
Authors
Cheung, WYChan, ACLLoke, SLSrivastava, GPittaluga, SLim, LYHo, FCS
KeywordsEpstein-Barr virus
Latency
Polymerase chain reaction, Southern blot hybridization
Issue Date1993
PublisherAmerican Society for Clinical Pathology. The Journal's web site is located at http://www.ajcp.com
Citation
American Journal Of Clinical Pathology, 1993, v. 100 n. 5, p. 502-506 How to Cite?
DOI: http://dx.doi.org/10.1093/ajcp/100.5.502
AbstractEpstein-Barr virus (EBV) has been detected in a wide spectrum of tumors. This study investigates the detection rate of EBV-DNA by Southern blot hybridization analysis (SOBH) and polymerase chain reaction (PCR) in different tissues from persons without apparent EBV-related diseases. Of 20 tonsillectomy specimens studied, SOBH indicated positivity for EBV-DNA in 1 case, and PCR indicated positivity in 10. In autopsies performed on patients with no apparent evidence of EBV-related diseases, the viral DNA was only detected by PCR in the following: parotid gland (7/15), submandibular gland (8/20), nasopharynx (8/10), tonsil (8/10), larynx (5/6), lung (5/9), cervical lymph node (7/10), mediastinal lymph node (7/10), abdominal lymph node (4/10), spleen (6/10), thyroid (5/10), liver (1/10), pancreas (1/4), kidney (4/10), uterine cervix (1/4), ovary (1/5) and testis (1/3). These results provide a baseline for interpreting the role of EBV in carcinogenesis.
Persistent Identifierhttp://hdl.handle.net/10722/147989
ISSN
0002-9173
2021 Impact Factor: 5.400
2020 SCImago Journal Rankings: 0.859
ISI Accession Number ID
WOS:A1993MH02300007

 

DC FieldValueLanguage
dc.contributor.authorCheung, WYen_US
dc.contributor.authorChan, ACLen_US
dc.contributor.authorLoke, SLen_US
dc.contributor.authorSrivastava, Gen_US
dc.contributor.authorPittaluga, Sen_US
dc.contributor.authorLim, LYen_US
dc.contributor.authorHo, FCSen_US
dc.date.accessioned2012-05-29T06:10:15Z-
dc.date.available2012-05-29T06:10:15Z-
dc.date.issued1993en_US
dc.identifier.citationAmerican Journal Of Clinical Pathology, 1993, v. 100 n. 5, p. 502-506en_US
dc.identifier.issn0002-9173en_US
dc.identifier.urihttp://hdl.handle.net/10722/147989-
dc.description.abstractEpstein-Barr virus (EBV) has been detected in a wide spectrum of tumors. This study investigates the detection rate of EBV-DNA by Southern blot hybridization analysis (SOBH) and polymerase chain reaction (PCR) in different tissues from persons without apparent EBV-related diseases. Of 20 tonsillectomy specimens studied, SOBH indicated positivity for EBV-DNA in 1 case, and PCR indicated positivity in 10. In autopsies performed on patients with no apparent evidence of EBV-related diseases, the viral DNA was only detected by PCR in the following: parotid gland (7/15), submandibular gland (8/20), nasopharynx (8/10), tonsil (8/10), larynx (5/6), lung (5/9), cervical lymph node (7/10), mediastinal lymph node (7/10), abdominal lymph node (4/10), spleen (6/10), thyroid (5/10), liver (1/10), pancreas (1/4), kidney (4/10), uterine cervix (1/4), ovary (1/5) and testis (1/3). These results provide a baseline for interpreting the role of EBV in carcinogenesis.en_US
dc.languageengen_US
dc.publisherAmerican Society for Clinical Pathology. The Journal's web site is located at http://www.ajcp.comen_US
dc.relation.ispartofAmerican Journal of Clinical Pathologyen_US
dc.subjectEpstein-Barr virus-
dc.subjectLatency-
dc.subjectPolymerase chain reaction, Southern blot hybridization-
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshBlotting, Southernen_US
dc.subject.meshCarrier State - Microbiologyen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshDna, Viral - Isolation & Purificationen_US
dc.subject.meshFemaleen_US
dc.subject.meshHerpesvirus 4, Human - Isolation & Purificationen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.titleLatent sites of Epstein-Barr virus infectionen_US
dc.typeArticleen_US
dc.identifier.emailSrivastava, G:gopesh@pathology.hku.hken_US
dc.identifier.authoritySrivastava, G=rp00365en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1093/ajcp/100.5.502-
dc.identifier.pmid8249889-
dc.identifier.scopuseid_2-s2.0-0027515510en_US
dc.identifier.volume100en_US
dc.identifier.issue5en_US
dc.identifier.spage502en_US
dc.identifier.epage506en_US
dc.identifier.isiWOS:A1993MH02300007-
dc.publisher.placeUnited Statesen_US
dc.identifier.issnl0002-9173-

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