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Article: Epstein-Barr virus infection and the pathogenesis of nasopharyngeal carcinoma: Viral gene expression, tumour cell phenotype, and the role of the lymphoid stroma

TitleEpstein-Barr virus infection and the pathogenesis of nasopharyngeal carcinoma: Viral gene expression, tumour cell phenotype, and the role of the lymphoid stroma
Authors
Niedobitek, GAgathanggelou, ANicholls, JM
KeywordsEBV
Nasopharyngeal carcinoma
Pathogenesis
Issue Date1996
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/semcancer
Citation
Seminars In Cancer Biology, 1996, v. 7 n. 4, p. 165-174 How to Cite?
DOI: http://dx.doi.org/10.1006/scbi.1996.0023
AbstractNasopharyngeal carcinoma (NPC) is the human tumour showing the most consistent association with Epstein-Barr virus (EBV). The recent detection of EBV in in-situ NPC lesions has shed light on the sequence of events leading to the development of invasive NPC and will be discussed in the context of what is known about EBV infection in non-neoplastic epithelial cells. The association of EBV with different histotypes of NPC will also be considered. EBV gene expression and NPC tumour cell phenotype will be discussed and evidence will be presented suggesting that the lymphoid stroma characteristically found in undifferentiated NPC is a prerequisite for the development of this tumour.
Persistent Identifierhttp://hdl.handle.net/10722/148061
ISSN
1044-579X
2021 Impact Factor: 17.012
2020 SCImago Journal Rankings: 3.908
ISI Accession Number ID
WOS:A1996VR85700002
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorNiedobitek, Gen_US
dc.contributor.authorAgathanggelou, Aen_US
dc.contributor.authorNicholls, JMen_US
dc.date.accessioned2012-05-29T06:10:38Z-
dc.date.available2012-05-29T06:10:38Z-
dc.date.issued1996en_US
dc.identifier.citationSeminars In Cancer Biology, 1996, v. 7 n. 4, p. 165-174en_US
dc.identifier.issn1044-579Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/148061-
dc.description.abstractNasopharyngeal carcinoma (NPC) is the human tumour showing the most consistent association with Epstein-Barr virus (EBV). The recent detection of EBV in in-situ NPC lesions has shed light on the sequence of events leading to the development of invasive NPC and will be discussed in the context of what is known about EBV infection in non-neoplastic epithelial cells. The association of EBV with different histotypes of NPC will also be considered. EBV gene expression and NPC tumour cell phenotype will be discussed and evidence will be presented suggesting that the lymphoid stroma characteristically found in undifferentiated NPC is a prerequisite for the development of this tumour.en_US
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/semcanceren_US
dc.relation.ispartofSeminars in Cancer Biologyen_US
dc.subjectEBV-
dc.subjectNasopharyngeal carcinoma-
dc.subjectPathogenesis-
dc.subject.meshCarcinoma - Classification - Virologyen_US
dc.subject.meshCarcinoma, Squamous Cell - Virologyen_US
dc.subject.meshCell Transformation, Viralen_US
dc.subject.meshDna Replicationen_US
dc.subject.meshDna, Viralen_US
dc.subject.meshGene Expression Regulation, Viralen_US
dc.subject.meshHerpesviridae Infectionsen_US
dc.subject.meshHerpesvirus 4, Human - Genetics - Physiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshInfectious Mononucleosis - Virologyen_US
dc.subject.meshNasopharyngeal Neoplasms - Virologyen_US
dc.subject.meshPhenotypeen_US
dc.subject.meshStromal Cells - Virologyen_US
dc.subject.meshTumor Virus Infectionsen_US
dc.subject.meshViral Matrix Proteins - Metabolismen_US
dc.subject.meshViral Proteins - Metabolismen_US
dc.subject.meshVirus Replicationen_US
dc.titleEpstein-Barr virus infection and the pathogenesis of nasopharyngeal carcinoma: Viral gene expression, tumour cell phenotype, and the role of the lymphoid stromaen_US
dc.typeArticleen_US
dc.identifier.emailNicholls, JM:nicholls@pathology.hku.hken_US
dc.identifier.authorityNicholls, JM=rp00364en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1006/scbi.1996.0023en_US
dc.identifier.pmid8946600en_US
dc.identifier.scopuseid_2-s2.0-0030221501en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030221501&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume7en_US
dc.identifier.issue4en_US
dc.identifier.spage165en_US
dc.identifier.epage174en_US
dc.identifier.isiWOS:A1996VR85700002-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.issnl1044-579X-

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