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- Publisher Website: 10.1016/S0165-4608(96)00245-2
- Scopus: eid_2-s2.0-0030612664
- PMID: 9169036
- WOS: WOS:A1997XA83100009
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Article: High frequency of telomeric associations in human ovarian surface epithelial cells transformed by human papilloma vital oncogenes
Title | High frequency of telomeric associations in human ovarian surface epithelial cells transformed by human papilloma vital oncogenes |
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Authors | |
Issue Date | 1997 |
Publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergene |
Citation | Cancer Genetics And Cytogenetics, 1997, v. 95 n. 2, p. 166-172 How to Cite? |
Abstract | Viral oncogenes are commonly used to transform and extend the in vitro life span of human epithelial cells. We have established 7 cell lines of human ovarian surface epithelial cells using human papilloma vital oncogenes (HPV-EGE7 ORFs). Cytogenetic analysis of the cell lines revealed a high frequency of telomeric associations ranging from 30% to 100% of the metaphases examined. The short arms of chromosomes 16, 19, 21, and 22 showed a higher rote of telomeric association. Telomeric association with other chromosomal ends appears to be random. Fusion of 2 chromosomes ends may contribute to the genomic instability of transformed cells and lead to further genetic alterations involved in malignant transformation such as gene amplication and loss of heterozygosity. This is the first report describing a high frequency of telomeric associations in human ovarian epithelial cells transformed by HPV oncogenes. |
Persistent Identifier | http://hdl.handle.net/10722/148065 |
ISSN | 2012 Impact Factor: 1.929 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Wan, TSK | en_HK |
dc.contributor.author | Chan, LC | en_HK |
dc.contributor.author | Ngan, HYS | en_HK |
dc.contributor.author | Tsao, SW | en_HK |
dc.date.accessioned | 2012-05-29T06:10:39Z | - |
dc.date.available | 2012-05-29T06:10:39Z | - |
dc.date.issued | 1997 | en_HK |
dc.identifier.citation | Cancer Genetics And Cytogenetics, 1997, v. 95 n. 2, p. 166-172 | en_HK |
dc.identifier.issn | 0165-4608 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/148065 | - |
dc.description.abstract | Viral oncogenes are commonly used to transform and extend the in vitro life span of human epithelial cells. We have established 7 cell lines of human ovarian surface epithelial cells using human papilloma vital oncogenes (HPV-EGE7 ORFs). Cytogenetic analysis of the cell lines revealed a high frequency of telomeric associations ranging from 30% to 100% of the metaphases examined. The short arms of chromosomes 16, 19, 21, and 22 showed a higher rote of telomeric association. Telomeric association with other chromosomal ends appears to be random. Fusion of 2 chromosomes ends may contribute to the genomic instability of transformed cells and lead to further genetic alterations involved in malignant transformation such as gene amplication and loss of heterozygosity. This is the first report describing a high frequency of telomeric associations in human ovarian epithelial cells transformed by HPV oncogenes. | en_HK |
dc.language | eng | en_US |
dc.publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergene | en_HK |
dc.relation.ispartof | Cancer Genetics and Cytogenetics | en_HK |
dc.rights | Cancer Genetics and Cytogenetics. Copyright © Elsevier Inc. | - |
dc.subject.mesh | Cell Transformation, Neoplastic - Genetics | en_US |
dc.subject.mesh | Cell Transformation, Viral - Genetics | en_US |
dc.subject.mesh | Chromosome Aberrations | en_US |
dc.subject.mesh | Epithelial Cells | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Karyotyping | en_US |
dc.subject.mesh | Oncogenes | en_US |
dc.subject.mesh | Ovary - Cytology | en_US |
dc.subject.mesh | Papillomaviridae - Genetics | en_US |
dc.subject.mesh | Telomere | en_US |
dc.title | High frequency of telomeric associations in human ovarian surface epithelial cells transformed by human papilloma vital oncogenes | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Chan, LC:chanlc@hkucc.hku.hk | en_HK |
dc.identifier.email | Ngan, HYS:hysngan@hkucc.hku.hk | en_HK |
dc.identifier.email | Tsao, SW:gswtsao@hkucc.hku.hk | en_HK |
dc.identifier.authority | Chan, LC=rp00373 | en_HK |
dc.identifier.authority | Ngan, HYS=rp00346 | en_HK |
dc.identifier.authority | Tsao, SW=rp00399 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/S0165-4608(96)00245-2 | en_HK |
dc.identifier.pmid | 9169036 | en_US |
dc.identifier.scopus | eid_2-s2.0-0030612664 | en_HK |
dc.identifier.hkuros | 33459 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0030612664&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 95 | en_HK |
dc.identifier.issue | 2 | en_HK |
dc.identifier.spage | 166 | en_HK |
dc.identifier.epage | 172 | en_HK |
dc.identifier.isi | WOS:A1997XA83100009 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Wan, TSK=25623981600 | en_HK |
dc.identifier.scopusauthorid | Chan, LC=7403540707 | en_HK |
dc.identifier.scopusauthorid | Ngan, HYS=34571944100 | en_HK |
dc.identifier.scopusauthorid | Tsao, SW=7102813116 | en_HK |
dc.identifier.issnl | 0165-4608 | - |