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- Publisher Website: 10.1002/(SICI)1097-0215(19970717)72:2<225::AID-IJC4>3.0.CO;2-T
- Scopus: eid_2-s2.0-0030802192
- PMID: 9219824
- WOS: WOS:A1997XH81000004
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Article: Prevalence of mutations and 30-bp deletion in the C-terminal region of Epstein-Barr virus latent membrane protein-1 oncogene in reactive lymphoid tissue and non-nasopharyngeal EBV-associated carcinomas in Hong Kong Chinese
Title | Prevalence of mutations and 30-bp deletion in the C-terminal region of Epstein-Barr virus latent membrane protein-1 oncogene in reactive lymphoid tissue and non-nasopharyngeal EBV-associated carcinomas in Hong Kong Chinese |
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Authors | |
Issue Date | 1997 |
Publisher | John Wiley & Sons, Inc.. The Journal's web site is located at http://www3.interscience.wiley.com/journal/29331/home |
Citation | International Journal Of Cancer, 1997, v. 72 n. 2, p. 225-230 How to Cite? |
Abstract | A specific variant of Epstein-Barr virus (EBV) with a 30-bp deletion in the C-terminal region of the LMPI gene has been found in some EBV-associated malignancies. To better understand the tumorigenic role of this LMPI variant, we used PCR and sequencing to examine the LMPI gene in 38 EBV-associated carcinomas (EBV-CAs) occurring in various organs (6 lung, 10 salivary gland, 5 sino-nasal, 16 gastric and I metastatic NPC), 55 reactive lymphoid tissues from tonsils (TON) and 67 EBV-negative tumours in various organs (22 adenolymphoma of salivary gland, 14 gastric and 31 colonic adenocarcinomas), where the virus was demonstrated in lymphocytes. The TON showed prevalence of both deleted and non-deleted variants of LMPI, with dual infection being common. Significantly more of the LMPI variant was deleted in EBV-CA and in EBV-negative tumours. Sequencing showed that the deleted and non-deleted variants have different sets of amino acid mutation. Mutations in codon 344 and 355 in the non-deleted variant disrupted the 9 nucleotide repeat flanking the deletion and thus may have conferred resistance to the deletion. The prevalence of both variants in the TON, with enrichment for the deleted variant in various organs, argues for the existence of an immune selection pressure in our population. The deleted variant, which may have a higher tumorigenic potential, may contribute to the high incidence of NPC, as well as the occurrence of EBV-CA in organs outside the nasopharynx in our locality. |
Persistent Identifier | http://hdl.handle.net/10722/148078 |
ISSN | 2023 Impact Factor: 5.7 2023 SCImago Journal Rankings: 2.131 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Leung, SY | en_HK |
dc.contributor.author | Yuen, ST | en_HK |
dc.contributor.author | Chung, LP | en_HK |
dc.contributor.author | Chan, ASY | en_HK |
dc.contributor.author | Wong, MP | en_HK |
dc.date.accessioned | 2012-05-29T06:10:43Z | - |
dc.date.available | 2012-05-29T06:10:43Z | - |
dc.date.issued | 1997 | en_HK |
dc.identifier.citation | International Journal Of Cancer, 1997, v. 72 n. 2, p. 225-230 | en_HK |
dc.identifier.issn | 0020-7136 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/148078 | - |
dc.description.abstract | A specific variant of Epstein-Barr virus (EBV) with a 30-bp deletion in the C-terminal region of the LMPI gene has been found in some EBV-associated malignancies. To better understand the tumorigenic role of this LMPI variant, we used PCR and sequencing to examine the LMPI gene in 38 EBV-associated carcinomas (EBV-CAs) occurring in various organs (6 lung, 10 salivary gland, 5 sino-nasal, 16 gastric and I metastatic NPC), 55 reactive lymphoid tissues from tonsils (TON) and 67 EBV-negative tumours in various organs (22 adenolymphoma of salivary gland, 14 gastric and 31 colonic adenocarcinomas), where the virus was demonstrated in lymphocytes. The TON showed prevalence of both deleted and non-deleted variants of LMPI, with dual infection being common. Significantly more of the LMPI variant was deleted in EBV-CA and in EBV-negative tumours. Sequencing showed that the deleted and non-deleted variants have different sets of amino acid mutation. Mutations in codon 344 and 355 in the non-deleted variant disrupted the 9 nucleotide repeat flanking the deletion and thus may have conferred resistance to the deletion. The prevalence of both variants in the TON, with enrichment for the deleted variant in various organs, argues for the existence of an immune selection pressure in our population. The deleted variant, which may have a higher tumorigenic potential, may contribute to the high incidence of NPC, as well as the occurrence of EBV-CA in organs outside the nasopharynx in our locality. | en_HK |
dc.language | eng | en_US |
dc.publisher | John Wiley & Sons, Inc.. The Journal's web site is located at http://www3.interscience.wiley.com/journal/29331/home | en_HK |
dc.relation.ispartof | International Journal of Cancer | en_HK |
dc.subject.mesh | Adolescent | en_US |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Aged | en_US |
dc.subject.mesh | Asian Continental Ancestry Group | en_US |
dc.subject.mesh | Child | en_US |
dc.subject.mesh | Gene Deletion | en_US |
dc.subject.mesh | Herpesvirus 4, Human - Genetics | en_US |
dc.subject.mesh | Hong Kong - Ethnology | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Lymphoid Tissue - Pathology - Virology | en_US |
dc.subject.mesh | Middle Aged | en_US |
dc.subject.mesh | Neoplasms - Epidemiology - Genetics - Pathology - Virology | en_US |
dc.subject.mesh | Oncogene Proteins, Viral - Genetics | en_US |
dc.subject.mesh | Prevalence | en_US |
dc.subject.mesh | Viral Matrix Proteins - Genetics | en_US |
dc.title | Prevalence of mutations and 30-bp deletion in the C-terminal region of Epstein-Barr virus latent membrane protein-1 oncogene in reactive lymphoid tissue and non-nasopharyngeal EBV-associated carcinomas in Hong Kong Chinese | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Leung, SY: suetyi@hku.hk | en_HK |
dc.identifier.email | Chung, LP: lpchung@hkucc.hku.hk | en_HK |
dc.identifier.email | Wong, MP: mwpik@hkucc.hku.hk | en_HK |
dc.identifier.authority | Leung, SY=rp00359 | en_HK |
dc.identifier.authority | Chung, LP=rp00249 | en_HK |
dc.identifier.authority | Wong, MP=rp00348 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1002/(SICI)1097-0215(19970717)72:2<225::AID-IJC4>3.0.CO;2-T | en_HK |
dc.identifier.pmid | 9219824 | - |
dc.identifier.scopus | eid_2-s2.0-0030802192 | en_HK |
dc.identifier.hkuros | 26131 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0030802192&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 72 | en_HK |
dc.identifier.issue | 2 | en_HK |
dc.identifier.spage | 225 | en_HK |
dc.identifier.epage | 230 | en_HK |
dc.identifier.isi | WOS:A1997XH81000004 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Leung, SY=7202044886 | en_HK |
dc.identifier.scopusauthorid | Yuen, ST=7103160927 | en_HK |
dc.identifier.scopusauthorid | Chung, LP=24315879100 | en_HK |
dc.identifier.scopusauthorid | Chan, ASY=55246984000 | en_HK |
dc.identifier.scopusauthorid | Wong, MP=7403907887 | en_HK |
dc.identifier.issnl | 0020-7136 | - |