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- PMID: 9144591
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Article: Monocyte chemoattractant protein-1 expression and macrophage infiltration in gliomas
Title | Monocyte chemoattractant protein-1 expression and macrophage infiltration in gliomas |
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Authors | |
Keywords | Glioma Macrophage Microglia Monocyte chemoattractant protein-1 |
Issue Date | 1997 |
Publisher | Springer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00401/index.htm |
Citation | Acta Neuropathologica, 1997, v. 93 n. 5, p. 518-527 How to Cite? |
Abstract | While the number of reports on macrophage infiltration of gliomas is increasing, the extent and mechanisms of macrophage recruitment remain unclear. To investigate whether monocyte chemoattractant protein-1 (MCP-1) plays a role in this process, in situ hybridisation (ISH) was performed for 22 glioblastomas (GBM), 1 anaplastic astrocytoma (AA) and 4 grade II fibrillary astrocytomas (AII) and reverse transcription-polymerase chain reaction was performed in 13 GBM, 1 AA and 3 AII. High levels of MCP-1 mRNA were detectable in most GBM, while a lower level was detected in AII. Many tumour-associated macrophages (TAM) could be demonstrated by immunohistochemistry (IHC) in most GBM, while the AII contained a lower number of TAM. The positive correlation between the MCP-1 level and abundance of TAM suggested that MCP-1 has a role in TAM recruitment. By combining ISH and IHC, high levels of MCP-1 mRNA were shown both in tumour cells and TAM. Along tumour borders, reactive astrocytes and microglia also expressed MCP-1. In areas with T lymphocyte infiltration, larger numbers of MCP-1-positive cells with an enhanced level of expression could be identified. We propose that the mechanism of macrophage recruitment is, at least partly, effected by constitutive expression and T cell-mediated up-regulation of MCP-1 in tumour cells and TAM. The production of MCP-1 by TAM establishes a positive amplification circuit for macrophage recruitment in gliomas. |
Persistent Identifier | http://hdl.handle.net/10722/148087 |
ISSN | 2023 Impact Factor: 9.3 2023 SCImago Journal Rankings: 4.720 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Leung, SY | en_HK |
dc.contributor.author | Wong, MP | en_HK |
dc.contributor.author | Chung, LP | en_HK |
dc.contributor.author | Chan, ASY | en_HK |
dc.contributor.author | Yuen, ST | en_HK |
dc.date.accessioned | 2012-05-29T06:10:46Z | - |
dc.date.available | 2012-05-29T06:10:46Z | - |
dc.date.issued | 1997 | en_HK |
dc.identifier.citation | Acta Neuropathologica, 1997, v. 93 n. 5, p. 518-527 | en_HK |
dc.identifier.issn | 0001-6322 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/148087 | - |
dc.description.abstract | While the number of reports on macrophage infiltration of gliomas is increasing, the extent and mechanisms of macrophage recruitment remain unclear. To investigate whether monocyte chemoattractant protein-1 (MCP-1) plays a role in this process, in situ hybridisation (ISH) was performed for 22 glioblastomas (GBM), 1 anaplastic astrocytoma (AA) and 4 grade II fibrillary astrocytomas (AII) and reverse transcription-polymerase chain reaction was performed in 13 GBM, 1 AA and 3 AII. High levels of MCP-1 mRNA were detectable in most GBM, while a lower level was detected in AII. Many tumour-associated macrophages (TAM) could be demonstrated by immunohistochemistry (IHC) in most GBM, while the AII contained a lower number of TAM. The positive correlation between the MCP-1 level and abundance of TAM suggested that MCP-1 has a role in TAM recruitment. By combining ISH and IHC, high levels of MCP-1 mRNA were shown both in tumour cells and TAM. Along tumour borders, reactive astrocytes and microglia also expressed MCP-1. In areas with T lymphocyte infiltration, larger numbers of MCP-1-positive cells with an enhanced level of expression could be identified. We propose that the mechanism of macrophage recruitment is, at least partly, effected by constitutive expression and T cell-mediated up-regulation of MCP-1 in tumour cells and TAM. The production of MCP-1 by TAM establishes a positive amplification circuit for macrophage recruitment in gliomas. | en_HK |
dc.language | eng | en_US |
dc.publisher | Springer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00401/index.htm | en_HK |
dc.relation.ispartof | Acta Neuropathologica | en_HK |
dc.subject | Glioma | en_HK |
dc.subject | Macrophage | en_HK |
dc.subject | Microglia | en_HK |
dc.subject | Monocyte chemoattractant protein-1 | en_HK |
dc.subject.mesh | Astrocytoma - Metabolism - Pathology | en_US |
dc.subject.mesh | Brain Neoplasms - Metabolism - Pathology | en_US |
dc.subject.mesh | Chemokine Ccl2 - Biosynthesis | en_US |
dc.subject.mesh | Glioblastoma - Metabolism - Pathology | en_US |
dc.subject.mesh | Glioma - Metabolism - Pathology | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Immunohistochemistry | en_US |
dc.subject.mesh | In Situ Hybridization | en_US |
dc.subject.mesh | Macrophages - Physiology | en_US |
dc.subject.mesh | Polymerase Chain Reaction | en_US |
dc.subject.mesh | Rna, Messenger - Biosynthesis | en_US |
dc.subject.mesh | T-Lymphocytes - Physiology | en_US |
dc.title | Monocyte chemoattractant protein-1 expression and macrophage infiltration in gliomas | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Leung, SY: suetyi@hku.hk | en_HK |
dc.identifier.email | Wong, MP: mwpik@hkucc.hku.hk | en_HK |
dc.identifier.email | Chung, LP: lpchung@hkucc.hku.hk | en_HK |
dc.identifier.authority | Leung, SY=rp00359 | en_HK |
dc.identifier.authority | Wong, MP=rp00348 | en_HK |
dc.identifier.authority | Chung, LP=rp00249 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1007/s004010050647 | en_HK |
dc.identifier.pmid | 9144591 | - |
dc.identifier.scopus | eid_2-s2.0-0030951515 | en_HK |
dc.identifier.hkuros | 26134 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0030951515&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 93 | en_HK |
dc.identifier.issue | 5 | en_HK |
dc.identifier.spage | 518 | en_HK |
dc.identifier.epage | 527 | en_HK |
dc.identifier.isi | WOS:A1997WW29400012 | - |
dc.publisher.place | Germany | en_HK |
dc.identifier.scopusauthorid | Leung, SY=7202044886 | en_HK |
dc.identifier.scopusauthorid | Wong, MP=7403907887 | en_HK |
dc.identifier.scopusauthorid | Chung, LP=24315879100 | en_HK |
dc.identifier.scopusauthorid | Chan, ASY=55246984000 | en_HK |
dc.identifier.scopusauthorid | Yuen, ST=7103160927 | en_HK |
dc.identifier.issnl | 0001-6322 | - |