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- Publisher Website: 10.1038/sj.bjc.6690092
- Scopus: eid_2-s2.0-0032938931
- PMID: 10027334
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Article: Microsatellite instability, Epstein-Barr virus, mutation of type II transforming growth factor β receptor and BAX in gastric carcinomas in Hong Kong Chinese
Title | Microsatellite instability, Epstein-Barr virus, mutation of type II transforming growth factor β receptor and BAX in gastric carcinomas in Hong Kong Chinese |
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Authors | |
Keywords | BAX Epstein-Barr virus Gastric carcinoma Hong Kong Chinese Microsatellite instability TβRII |
Issue Date | 1999 |
Publisher | Nature Publishing Group. The Journal's web site is located at http://www.nature.com/bjc |
Citation | British Journal Of Cancer, 1999, v. 79 n. 3-4, p. 582-588 How to Cite? |
Abstract | Microsatellite instability (MI), the phenotypic manifestation of mismatch repair failure, is found in a proportion of gastric carcinomas. Little is known of the links between MI and Epstein-Barr virus (EBV) status and clinicopathological elements. Examination of genes mutated through the MI mechanism could also be expected to reveal important information on the carcinogenic pathway. Seventy-nine gastric carcinomas (61 EBV negative, 18 EBV positive) from local Hong Kong Chinese population, an intermediate-incidence area, were examined. Eight microsatellite loci, inclusive of the A10 tract of type II transforming growth factor β receptor (TβR-II), were used to evaluate the MI status. MI in the BAX and insulin-like growth factor II receptor (IGF-IIR) genes were also examined. High-level MI (> 40% unstable loci) was detected in ten cases (12.7%) and low-level MI (1-40% unstable loci) in three (3.8%). High-level MI was detected in two EBV-associated cases (11%) and the incidence was similar for the EBV-negative cases (13%). The high-level MIs were significantly associated with intestinal-type tumours (P = 0.03) and a more prominent lymphoid infiltrate (P = 0.04). Similar associations were noted in the EBV-positive carcinomas. The high-level MIs were more commonly located in the antrum, whereas the EBV-associated carcinomas were mostly located in body. Thirteen cardia cases were negative for both high-level MI and EBV. All patients aged below 55 were MI negative (P = 0.049). Of the high-level MIs, 80% had mutation in TβR-II, 40% in BAX and 0% in IGF-IIR. Of low-level MIs, 33% also had TβR-II mutation. These mutations were absent in the MI-negative cases. Of three lymphoepithelioma-like carcinomas, two cases were EBV positive and MI negative, one case was EBV negative but with high-level MI. In conclusion, high-level MIs were present regardless of the EBV status, and were found in a particular clinicopathological subset of gastric carcinoma patient. Inactivation of important growth regulatory genes observed in these carcinomas confirms the importance of MI in carcinogenesis. |
Persistent Identifier | http://hdl.handle.net/10722/148158 |
ISSN | 2023 Impact Factor: 6.4 2023 SCImago Journal Rankings: 3.000 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Leung, SY | en_HK |
dc.contributor.author | Yuen, ST | en_HK |
dc.contributor.author | Chung, LP | en_HK |
dc.contributor.author | Chu, KM | en_HK |
dc.contributor.author | Wong, MP | en_HK |
dc.contributor.author | Branicki, FJ | en_HK |
dc.contributor.author | Ho, JCI | en_HK |
dc.date.accessioned | 2012-05-29T06:11:10Z | - |
dc.date.available | 2012-05-29T06:11:10Z | - |
dc.date.issued | 1999 | en_HK |
dc.identifier.citation | British Journal Of Cancer, 1999, v. 79 n. 3-4, p. 582-588 | en_HK |
dc.identifier.issn | 0007-0920 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/148158 | - |
dc.description.abstract | Microsatellite instability (MI), the phenotypic manifestation of mismatch repair failure, is found in a proportion of gastric carcinomas. Little is known of the links between MI and Epstein-Barr virus (EBV) status and clinicopathological elements. Examination of genes mutated through the MI mechanism could also be expected to reveal important information on the carcinogenic pathway. Seventy-nine gastric carcinomas (61 EBV negative, 18 EBV positive) from local Hong Kong Chinese population, an intermediate-incidence area, were examined. Eight microsatellite loci, inclusive of the A10 tract of type II transforming growth factor β receptor (TβR-II), were used to evaluate the MI status. MI in the BAX and insulin-like growth factor II receptor (IGF-IIR) genes were also examined. High-level MI (> 40% unstable loci) was detected in ten cases (12.7%) and low-level MI (1-40% unstable loci) in three (3.8%). High-level MI was detected in two EBV-associated cases (11%) and the incidence was similar for the EBV-negative cases (13%). The high-level MIs were significantly associated with intestinal-type tumours (P = 0.03) and a more prominent lymphoid infiltrate (P = 0.04). Similar associations were noted in the EBV-positive carcinomas. The high-level MIs were more commonly located in the antrum, whereas the EBV-associated carcinomas were mostly located in body. Thirteen cardia cases were negative for both high-level MI and EBV. All patients aged below 55 were MI negative (P = 0.049). Of the high-level MIs, 80% had mutation in TβR-II, 40% in BAX and 0% in IGF-IIR. Of low-level MIs, 33% also had TβR-II mutation. These mutations were absent in the MI-negative cases. Of three lymphoepithelioma-like carcinomas, two cases were EBV positive and MI negative, one case was EBV negative but with high-level MI. In conclusion, high-level MIs were present regardless of the EBV status, and were found in a particular clinicopathological subset of gastric carcinoma patient. Inactivation of important growth regulatory genes observed in these carcinomas confirms the importance of MI in carcinogenesis. | en_HK |
dc.language | eng | en_US |
dc.publisher | Nature Publishing Group. The Journal's web site is located at http://www.nature.com/bjc | en_HK |
dc.relation.ispartof | British Journal of Cancer | en_HK |
dc.subject | BAX | en_HK |
dc.subject | Epstein-Barr virus | en_HK |
dc.subject | Gastric carcinoma | en_HK |
dc.subject | Hong Kong Chinese | en_HK |
dc.subject | Microsatellite instability | en_HK |
dc.subject | TβRII | en_HK |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Aged | en_US |
dc.subject.mesh | Carcinoma - Genetics - Pathology - Virology | en_US |
dc.subject.mesh | Cell Transformation, Neoplastic - Genetics | en_US |
dc.subject.mesh | Dna Mutational Analysis | en_US |
dc.subject.mesh | Dna, Neoplasm - Genetics | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Genes, Tumor Suppressor - Genetics | en_US |
dc.subject.mesh | Herpesviridae Infections - Complications | en_US |
dc.subject.mesh | Herpesvirus 4, Human - Pathogenicity | en_US |
dc.subject.mesh | Hong Kong | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Microsatellite Repeats - Genetics | en_US |
dc.subject.mesh | Middle Aged | en_US |
dc.subject.mesh | Proto-Oncogene Proteins - Genetics | en_US |
dc.subject.mesh | Proto-Oncogene Proteins C-Bcl-2 | en_US |
dc.subject.mesh | Receptors, Transforming Growth Factor Beta - Genetics | en_US |
dc.subject.mesh | Stomach Neoplasms - Genetics - Pathology - Virology | en_US |
dc.subject.mesh | Tumor Virus Infections - Complications | en_US |
dc.subject.mesh | Bcl-2-Associated X Protein | en_US |
dc.title | Microsatellite instability, Epstein-Barr virus, mutation of type II transforming growth factor β receptor and BAX in gastric carcinomas in Hong Kong Chinese | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Leung, SY: suetyi@hku.hk | en_HK |
dc.identifier.email | Chung, LP: lpchung@hkucc.hku.hk | en_HK |
dc.identifier.email | Chu, KM: chukm@hkucc.hku.hk | en_HK |
dc.identifier.email | Wong, MP: mwpik@hkucc.hku.hk | en_HK |
dc.identifier.authority | Leung, SY=rp00359 | en_HK |
dc.identifier.authority | Chung, LP=rp00249 | en_HK |
dc.identifier.authority | Chu, KM=rp00435 | en_HK |
dc.identifier.authority | Wong, MP=rp00348 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1038/sj.bjc.6690092 | en_HK |
dc.identifier.pmid | 10027334 | - |
dc.identifier.scopus | eid_2-s2.0-0032938931 | en_HK |
dc.identifier.hkuros | 39506 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0032938931&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 79 | en_HK |
dc.identifier.issue | 3-4 | en_HK |
dc.identifier.spage | 582 | en_HK |
dc.identifier.epage | 588 | en_HK |
dc.identifier.isi | WOS:000078165200033 | - |
dc.publisher.place | United Kingdom | en_HK |
dc.identifier.scopusauthorid | Leung, SY=7202044886 | en_HK |
dc.identifier.scopusauthorid | Yuen, ST=7103160927 | en_HK |
dc.identifier.scopusauthorid | Chung, LP=24315879100 | en_HK |
dc.identifier.scopusauthorid | Chu, KM=7402453538 | en_HK |
dc.identifier.scopusauthorid | Wong, MP=7403907887 | en_HK |
dc.identifier.scopusauthorid | Branicki, FJ=7003617514 | en_HK |
dc.identifier.scopusauthorid | Ho, JCI=15029093800 | en_HK |
dc.identifier.issnl | 0007-0920 | - |