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- Publisher Website: 10.1046/j.1365-2559.1999.00582.x
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- PMID: 9934580
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Article: Phenotypic and cytotoxic characteristics of peripheral T-cell and NK-cell lymphomas in relation to Epstein-Barr virus association
Title | Phenotypic and cytotoxic characteristics of peripheral T-cell and NK-cell lymphomas in relation to Epstein-Barr virus association |
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Authors | |
Keywords | Cytotoxic cell antigen EBV Epstein-Barr virus NK-cell lymphoma Phenotype T-cell lymphoma TIA- 1 |
Issue Date | 1999 |
Publisher | Blackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/HIS |
Citation | Histopathology, 1999, v. 34 n. 1, p. 16-24 How to Cite? |
Abstract | AIMS: We investigated the phenotypic and cytotoxic characteristics of different types of peripheral T-cell and NK-cell lymphomas and correlated the findings of cytotoxic phenotype with Epstein-Barr virus (EBV) association. METHODS AND RESULTS: Eighty cases of peripheral T-cell and NK-cell lymphomas, classified according to the REAL classification, were investigated for cytotoxic phenotype (by studying T-cell intracellular antigen-1 (TIA-1) expression immunohistochemically) and EBV association (by in situ hybridization for EBV-encoded small non-polyadenylated RNAs), and the results were correlated with the specific clinicopathological types and the immunophenotype with special emphasis on CD56 expression and CD4/CD8 status. Overall, 39/80 cases (49%) expressed TIA-1. Angiocentric lymphoma (23/24 cases; 96%), aggressive NK-cell leukaemia ('large granular lymphocyte (LGL) leukaemia') (3/3 cases; 100%), intestinal T-cell lymphoma (5/6 cases; 83%) and anaplastic large cell lymphoma (4/6 cases; 67%) were the major subtypes showing a cytotoxic phenotype. Only four of the 27 cases (15%) of peripheral T-cell lymphoma, unspecified, were TIA-1+, while all the seven cases of angioimmunoblastic T-cell lymphoma, six cases of mycosis fungoides and one case of adult T-cell lymphoma/leukaemia were TIA-1-. CONCLUSIONS: Within the group of peripheral T-cell and NK-cell lymphomas, angiocentric lymphoma, aggressive NK-cell leukaemia ('LGL leukaemia'), intestinal T-cell lymphoma and anaplastic large cell lymphoma are the major subtypes displaying a cytotoxic phenotype. The relationships between the cytotoxic phenotype and EBV association, CD56 expression or CD4/CD8 status are secondary to the relationship between cytotoxic phenotype and specific lymphoma subtype. |
Persistent Identifier | http://hdl.handle.net/10722/148162 |
ISSN | 2023 Impact Factor: 3.9 2023 SCImago Journal Rankings: 1.392 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chan, ACL | en_HK |
dc.contributor.author | Ho, JWY | en_HK |
dc.contributor.author | Chiang, AKS | en_HK |
dc.contributor.author | Srivastava, G | en_HK |
dc.date.accessioned | 2012-05-29T06:11:11Z | - |
dc.date.available | 2012-05-29T06:11:11Z | - |
dc.date.issued | 1999 | en_HK |
dc.identifier.citation | Histopathology, 1999, v. 34 n. 1, p. 16-24 | en_HK |
dc.identifier.issn | 0309-0167 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/148162 | - |
dc.description.abstract | AIMS: We investigated the phenotypic and cytotoxic characteristics of different types of peripheral T-cell and NK-cell lymphomas and correlated the findings of cytotoxic phenotype with Epstein-Barr virus (EBV) association. METHODS AND RESULTS: Eighty cases of peripheral T-cell and NK-cell lymphomas, classified according to the REAL classification, were investigated for cytotoxic phenotype (by studying T-cell intracellular antigen-1 (TIA-1) expression immunohistochemically) and EBV association (by in situ hybridization for EBV-encoded small non-polyadenylated RNAs), and the results were correlated with the specific clinicopathological types and the immunophenotype with special emphasis on CD56 expression and CD4/CD8 status. Overall, 39/80 cases (49%) expressed TIA-1. Angiocentric lymphoma (23/24 cases; 96%), aggressive NK-cell leukaemia ('large granular lymphocyte (LGL) leukaemia') (3/3 cases; 100%), intestinal T-cell lymphoma (5/6 cases; 83%) and anaplastic large cell lymphoma (4/6 cases; 67%) were the major subtypes showing a cytotoxic phenotype. Only four of the 27 cases (15%) of peripheral T-cell lymphoma, unspecified, were TIA-1+, while all the seven cases of angioimmunoblastic T-cell lymphoma, six cases of mycosis fungoides and one case of adult T-cell lymphoma/leukaemia were TIA-1-. CONCLUSIONS: Within the group of peripheral T-cell and NK-cell lymphomas, angiocentric lymphoma, aggressive NK-cell leukaemia ('LGL leukaemia'), intestinal T-cell lymphoma and anaplastic large cell lymphoma are the major subtypes displaying a cytotoxic phenotype. The relationships between the cytotoxic phenotype and EBV association, CD56 expression or CD4/CD8 status are secondary to the relationship between cytotoxic phenotype and specific lymphoma subtype. | en_HK |
dc.language | eng | en_US |
dc.publisher | Blackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/HIS | en_HK |
dc.relation.ispartof | Histopathology | en_HK |
dc.rights | Histopathology. Copyright © Blackwell Publishing Ltd. | - |
dc.subject | Cytotoxic cell antigen | en_HK |
dc.subject | EBV | en_HK |
dc.subject | Epstein-Barr virus | en_HK |
dc.subject | NK-cell lymphoma | en_HK |
dc.subject | Phenotype | en_HK |
dc.subject | T-cell lymphoma | en_HK |
dc.subject | TIA- 1 | en_HK |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Antigens, Cd56 - Metabolism | en_US |
dc.subject.mesh | Cd4-Cd8 Ratio | en_US |
dc.subject.mesh | Herpesvirus 4, Human - Isolation & Purification | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Immunophenotyping | en_US |
dc.subject.mesh | In Situ Hybridization | en_US |
dc.subject.mesh | Killer Cells, Natural - Cytology - Immunology - Virology | en_US |
dc.subject.mesh | Lymphoma - Immunology - Pathology - Virology | en_US |
dc.subject.mesh | Lymphoma, T-Cell, Peripheral - Immunology - Pathology - Virology | en_US |
dc.subject.mesh | Rna, Viral - Analysis | en_US |
dc.title | Phenotypic and cytotoxic characteristics of peripheral T-cell and NK-cell lymphomas in relation to Epstein-Barr virus association | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Chiang, AKS: chiangak@hkucc.hku.hk | en_HK |
dc.identifier.email | Srivastava, G: gopesh@pathology.hku.hk | en_HK |
dc.identifier.authority | Chiang, AKS=rp00403 | en_HK |
dc.identifier.authority | Srivastava, G=rp00365 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1046/j.1365-2559.1999.00582.x | en_HK |
dc.identifier.pmid | 9934580 | - |
dc.identifier.scopus | eid_2-s2.0-0033003926 | en_HK |
dc.identifier.hkuros | 43069 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0033003926&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 34 | en_HK |
dc.identifier.issue | 1 | en_HK |
dc.identifier.spage | 16 | en_HK |
dc.identifier.epage | 24 | en_HK |
dc.identifier.isi | WOS:000078327100004 | - |
dc.publisher.place | United Kingdom | en_HK |
dc.identifier.scopusauthorid | Chan, ACL=16047349300 | en_HK |
dc.identifier.scopusauthorid | Ho, JWY=7402649982 | en_HK |
dc.identifier.scopusauthorid | Chiang, AKS=7101623534 | en_HK |
dc.identifier.scopusauthorid | Srivastava, G=7202242238 | en_HK |
dc.customcontrol.immutable | sml 130621 | - |
dc.identifier.issnl | 0309-0167 | - |