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- Scopus: eid_2-s2.0-33644825803
- PMID: 16212894
- WOS: WOS:000208922200002
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Article: The pre-B cell receptor and its function during B cell development.
Title | The pre-B cell receptor and its function during B cell development. |
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Authors | |
Issue Date | 2004 |
Publisher | Chinese Society of Immunology. The Journal's web site is located at http://www.nature.com/cmi/index.html |
Citation | Cellular & Molecular Immunology., 2004, v. 1 n. 2, p. 89-94 How to Cite? |
Abstract | The process of B cell development in the bone marrow occurs by the stepwise rearrangements of the V, D, and J segments of the Ig H and L chain gene loci. During early B cell genesis, productive Ig H chain gene rearrangement leads to assembly of the pre-B cell receptor (pre-BCR), which acts as an important checkpoint at the pro-B/preB transitional stage. The pre-BCR, transiently expressed by developing precursor B cells, comprises the Ig muH chain, surrogate light (SL) chains VpreB and lambda5, as well as the signal-transducing heterodimer Ig alpha/Ig beta. Signaling through the pre-BCR regulates allelic exclusion at the Ig H locus, stimulates cell proliferation, and induces differentiation to small post-mitotic pre-B cells that further undergo the rearrangement of the Ig L chain genes. Recent advances in elucidating the key roles of pre-BCR in B cell development have provided a better understanding of normal B lymphopoiesis and its dysregulated state leading to B cell neoplasia. |
Persistent Identifier | http://hdl.handle.net/10722/148453 |
ISSN | 2023 Impact Factor: 21.8 2023 SCImago Journal Rankings: 4.838 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Zhang, M | en_US |
dc.contributor.author | Srivastava, G | en_US |
dc.contributor.author | Lu, L | en_US |
dc.date.accessioned | 2012-05-29T06:13:04Z | - |
dc.date.available | 2012-05-29T06:13:04Z | - |
dc.date.issued | 2004 | en_US |
dc.identifier.citation | Cellular & Molecular Immunology., 2004, v. 1 n. 2, p. 89-94 | en_US |
dc.identifier.issn | 1672-7681 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/148453 | - |
dc.description.abstract | The process of B cell development in the bone marrow occurs by the stepwise rearrangements of the V, D, and J segments of the Ig H and L chain gene loci. During early B cell genesis, productive Ig H chain gene rearrangement leads to assembly of the pre-B cell receptor (pre-BCR), which acts as an important checkpoint at the pro-B/preB transitional stage. The pre-BCR, transiently expressed by developing precursor B cells, comprises the Ig muH chain, surrogate light (SL) chains VpreB and lambda5, as well as the signal-transducing heterodimer Ig alpha/Ig beta. Signaling through the pre-BCR regulates allelic exclusion at the Ig H locus, stimulates cell proliferation, and induces differentiation to small post-mitotic pre-B cells that further undergo the rearrangement of the Ig L chain genes. Recent advances in elucidating the key roles of pre-BCR in B cell development have provided a better understanding of normal B lymphopoiesis and its dysregulated state leading to B cell neoplasia. | en_US |
dc.language | eng | en_US |
dc.publisher | Chinese Society of Immunology. The Journal's web site is located at http://www.nature.com/cmi/index.html | en_US |
dc.relation.ispartof | Cellular & molecular immunology. | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | B-Lymphocytes - Immunology - Physiology | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Immunoglobulin Heavy Chains - Metabolism | en_US |
dc.subject.mesh | Membrane Glycoproteins - Immunology | en_US |
dc.subject.mesh | Multiprotein Complexes | en_US |
dc.subject.mesh | Pre-B Cell Receptors | en_US |
dc.subject.mesh | Receptors, Antigen, B-Cell | en_US |
dc.subject.mesh | Signal Transduction - Physiology | en_US |
dc.title | The pre-B cell receptor and its function during B cell development. | en_US |
dc.type | Article | en_US |
dc.identifier.email | Srivastava, G:gopesh@pathology.hku.hk | en_US |
dc.identifier.email | Lu, L:liweilu@hkucc.hku.hk | en_US |
dc.identifier.authority | Srivastava, G=rp00365 | en_US |
dc.identifier.authority | Lu, L=rp00477 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.pmid | 16212894 | - |
dc.identifier.scopus | eid_2-s2.0-33644825803 | en_US |
dc.identifier.hkuros | 87420 | - |
dc.identifier.hkuros | 139352 | - |
dc.identifier.volume | 1 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.spage | 89 | en_US |
dc.identifier.epage | 94 | en_US |
dc.identifier.isi | WOS:000208922200002 | - |
dc.publisher.place | China | en_US |
dc.identifier.issnl | 1672-7681 | - |