The work of UK groups is supported by grants from Cancer Research UK and the European Union. In Wales, work is supported by grants from Cancer Research Wales to J.P.C. and Tenovus to J.P.C. We acknowledge the use of DNA from the UKBS, funded by the Wellcome Trust (grant 06113/C/04/Z); by the Juvenile Diabetes Research Foundation grant WT061858 and by the National Institute of Health Research of England. In Spain, work is supported by grants from the Instituto de Salud Carlos III, grants FIS 05/1006, 08/1359, 08/1635 and European Commission FP6 Food-CT-2006-036224 to V. M.. In Canada, work is supported by grants from the Ontario Research Fund from the Ontario Ministry of Research and Innovation, The Canadian Cancer Society Research Institute, the Canadian Institutes of Health Research and the Ontario Institute for Cancer Research. In Finland, work is supported by grants from Academy of Finland (Finnish Centre of Excellence Program 2006-2011), the Sigrid Juselius Foundation, the Finnish Cancer Societies and the European Union. The work of the DFKS is supported by the German Genome Network (NGFNplus). In the Czech Republic, work is supported by GACR 310/07/1430 and P304/10/1286. In Sweden, work is supported by grants from the Swedish Cancer Foundation and the Swedish Research Council. In Barcelona and Santiago (Epicolon), work is supported by grants from Fondo de Investigacion Sanitaria/FEDR (08/0024, 08/1276, PS09/02368, 11/00219, 11/0068), Xunta de Galicia (PGI-DIT07PXIB9101209PR), Ministerio de Educacion y Ciencia (SAF2010-19273), Asociacion Espanola contra el Cancer (Fundacion Cientifica y Junta de Barcelona) Fundacion Olga Torres to C. R. P. and Accion Transversal contra el Cancer (Instituto de Salud Carlos III) and FP& CHIBCHA Constrotium to S. C. B. and Angel Carracedo CIBERER and CIBEREHD are funded by the Instituto de Salud Carlos III. S. C. B. is supported by a contract from the Fondo de Investigacion Sanitaria (CP 03-0070, Ministerio de Sanidad). The work was carried out (in part) at the Esteher Koplowtiz Centre, Barcelona. In the Netherlands, work of R. M. W. H is supported by the Dutch Cancer Society, the European Community, and the work of J.T.W., T.vW., H. M. and PD by the Dutch Cancer Society (UL2005-3247) and Fonds NutsOhra. In Hong Kong, work is supported by grants from the Michael and Betty Kadoorie Cancer Genetics Research Programme II; and the Bobby Moore Fund of Cancer Research UK. Work in Australia is conducted under the auspices of the Hilton Ludwig Cancer Metastasis Initiative and supported by a grant from the NHMRC (Project Grant 489418). In Japan, this work was conducted as a part of the BioBank Japan Project that was supported by the Ministry of Education, Culture, Sports, Sciences and Technology of Japanese government. The ESTHER and VERDI studies are supported by grants from the Baden Wurttemberg Ministry of Research, Science and Arts and the German Cancer Aid (Deutsche Krebshilfe), grant M24/95/BR I. The Kiel cohort (POPGEN) is funded through the German Ministry of Education and Reserach through the POPGEN Biobank grant and the Colon Cancer Network of the German National Genome Research Network. SHIP is part of the Community Medicine Research net of the University of Greifswald, Germany, which is funded by the Federal Ministry of Education and Research, the Ministry of Cultural Affairs as well as the Social Ministry of the Federal State of Mecklenburg-West Pomerania. Genome-wide data have been supported by the Federal Ministry of Education and Research (grant no.