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Article: The potential molecular therapeutic approach in targeting ovarian clear cell carcinoma

TitleThe potential molecular therapeutic approach in targeting ovarian clear cell carcinoma
Authors
Chan, DWNgan, HYS
KeywordsGRB7
ERK
FOXM1
Ovarian cancer
High-grade tumor
Issue Date2012
PublisherOmics Publishing Group. The Journal's web site is located at http://omicsonline.org/gynecologyhome.php
Citation
Gynecology & Obstetrics, 2012, v. 2 n. 2, article no. e103 How to Cite?
DOI: http://dx.doi.org/10.4172/2161-0932.1000e103
AbstractOvarian Clear Cell Carcinoma (OCCC) is a distinctive subtype of Epithelial Ovarian Cancer (EOC). Compared with other subtypes of EOC, CCC has relatively poor in prognosis and bad outcome in current clinical management using maximal cytoreduction and platinum plus paclitaxel–based combined chemotherapy. Therefore, the investigation of molecular therapeutic approaches targeting at signaling pathways associated with chemoresistance is needed. This review describes some recent potential signaling pathway targets and also suggests putative small molecule kinase inhibitors as well as natural anti-cancer agents in combating this disease.
DescriptionEditorial
Persistent Identifierhttp://hdl.handle.net/10722/149180
ISSN
2161-0932

 

DC FieldValueLanguage
dc.contributor.authorChan, DWen_US
dc.contributor.authorNgan, HYSen_US
dc.date.accessioned2012-06-22T06:27:59Z-
dc.date.available2012-06-22T06:27:59Z-
dc.date.issued2012en_US
dc.identifier.citationGynecology & Obstetrics, 2012, v. 2 n. 2, article no. e103en_US
dc.identifier.issn2161-0932-
dc.identifier.urihttp://hdl.handle.net/10722/149180-
dc.descriptionEditorial-
dc.description.abstractOvarian Clear Cell Carcinoma (OCCC) is a distinctive subtype of Epithelial Ovarian Cancer (EOC). Compared with other subtypes of EOC, CCC has relatively poor in prognosis and bad outcome in current clinical management using maximal cytoreduction and platinum plus paclitaxel–based combined chemotherapy. Therefore, the investigation of molecular therapeutic approaches targeting at signaling pathways associated with chemoresistance is needed. This review describes some recent potential signaling pathway targets and also suggests putative small molecule kinase inhibitors as well as natural anti-cancer agents in combating this disease.-
dc.languageengen_US
dc.publisherOmics Publishing Group. The Journal's web site is located at http://omicsonline.org/gynecologyhome.phpen_US
dc.relation.ispartofGynecology & Obstetricsen_US
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectGRB7-
dc.subjectERK-
dc.subjectFOXM1-
dc.subjectOvarian cancer-
dc.subjectHigh-grade tumor-
dc.titleThe potential molecular therapeutic approach in targeting ovarian clear cell carcinomaen_US
dc.typeArticleen_US
dc.identifier.emailChan, DW: dwchan@hku.hken_US
dc.identifier.emailNgan, HYS: hysngan@hku.hken_US
dc.identifier.authorityChan, DW=rp00543en_US
dc.identifier.authorityNgan, HYS=rp00346en_US
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.4172/2161-0932.1000e103-
dc.identifier.hkuros199851en_US
dc.identifier.volume2en_US
dc.identifier.issue2-
dc.publisher.placeUnited States-
dc.identifier.issnl2161-0932-

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