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- PMID: 21988112
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Article: Elevated blood pressure aggravates intracerebral hemorrhage-induced brain injury
Title | Elevated blood pressure aggravates intracerebral hemorrhage-induced brain injury | ||||||
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Authors | |||||||
Keywords | cell proliferation functional deficits hypertension intracerebral hemorrhage | ||||||
Issue Date | 2011 | ||||||
Publisher | Mary Ann Liebert, Inc Publishers. The Journal's web site is located at http://www.liebertpub.com/neu | ||||||
Citation | Journal Of Neurotrauma, 2011, v. 28 n. 12, p. 2523-2534 How to Cite? | ||||||
Abstract | Elevated blood pressure (BP) is commonly seen in patients with intracerebral hemorrhage (ICH), and is independently associated with poor functional outcomes. Little is known about how elevated BP influences ICH-related brain injury. In the present study, we investigated the physiological and brain histological changes, as well as functional recovery following ICH in renovascular hypertensive rats. Renovascular hypertension (RVHT) was achieved by applying a silver clip onto the left renal artery of adult Sprague-Dawley rats. ICH was induced by an intrastriatal injection of bacterial collagenase IV about 5-6 weeks after left renal artery clipping or the sham operation. Following induction of ICH, both the normotensive and RVHT rats demonstrated an ultra-acute elevation in BP. Elevated BP increased hematoma volume, brain swelling, and apoptosis in the perihematomal areas. Brain degeneration, including local atrophy and lateral ventricle enlargement, was greater in the RVHT rats. In addition, many proliferating cells were seen over the ipsilateral striatum in the RVHT rats after ICH. The modified limb placing tests were done weekly for 3 weeks. In line with the histological damage, elevated BP worsened neurological deficits. These results suggest that ICH in the hypertensive rats mimics the clinical scenario of hypertensive ICH and may provide a platform to study the mechanisms of ICH-induced brain injury and potential therapies for ICH. © 2011, Mary Ann Liebert, Inc. | ||||||
Persistent Identifier | http://hdl.handle.net/10722/149774 | ||||||
ISSN | 2023 Impact Factor: 3.9 2023 SCImago Journal Rankings: 1.483 | ||||||
PubMed Central ID | |||||||
ISI Accession Number ID |
Funding Information: This work was supported by a General Research Fund of Research Grants Council (HKU763109M) and Committee on Research and Conference Grants (200707176018, 200807176052, 201007176091). | ||||||
References | |||||||
Grants |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sang, YH | en_HK |
dc.contributor.author | Su, HX | en_HK |
dc.contributor.author | Wu, WT | en_HK |
dc.contributor.author | So, KF | en_HK |
dc.contributor.author | Cheung, RTF | en_HK |
dc.date.accessioned | 2012-06-26T05:58:25Z | - |
dc.date.available | 2012-06-26T05:58:25Z | - |
dc.date.issued | 2011 | en_HK |
dc.identifier.citation | Journal Of Neurotrauma, 2011, v. 28 n. 12, p. 2523-2534 | en_HK |
dc.identifier.issn | 0897-7151 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/149774 | - |
dc.description.abstract | Elevated blood pressure (BP) is commonly seen in patients with intracerebral hemorrhage (ICH), and is independently associated with poor functional outcomes. Little is known about how elevated BP influences ICH-related brain injury. In the present study, we investigated the physiological and brain histological changes, as well as functional recovery following ICH in renovascular hypertensive rats. Renovascular hypertension (RVHT) was achieved by applying a silver clip onto the left renal artery of adult Sprague-Dawley rats. ICH was induced by an intrastriatal injection of bacterial collagenase IV about 5-6 weeks after left renal artery clipping or the sham operation. Following induction of ICH, both the normotensive and RVHT rats demonstrated an ultra-acute elevation in BP. Elevated BP increased hematoma volume, brain swelling, and apoptosis in the perihematomal areas. Brain degeneration, including local atrophy and lateral ventricle enlargement, was greater in the RVHT rats. In addition, many proliferating cells were seen over the ipsilateral striatum in the RVHT rats after ICH. The modified limb placing tests were done weekly for 3 weeks. In line with the histological damage, elevated BP worsened neurological deficits. These results suggest that ICH in the hypertensive rats mimics the clinical scenario of hypertensive ICH and may provide a platform to study the mechanisms of ICH-induced brain injury and potential therapies for ICH. © 2011, Mary Ann Liebert, Inc. | en_HK |
dc.language | eng | en_US |
dc.publisher | Mary Ann Liebert, Inc Publishers. The Journal's web site is located at http://www.liebertpub.com/neu | en_HK |
dc.relation.ispartof | Journal of Neurotrauma | en_HK |
dc.rights | This is a copy of an article published in the Journal of Neurotrauma © 2011 copyright Mary Ann Liebert, Inc.; Journal of Neurotrauma is available online at: http://www.liebertonline.com. | - |
dc.subject | cell proliferation | en_HK |
dc.subject | functional deficits | en_HK |
dc.subject | hypertension | en_HK |
dc.subject | intracerebral hemorrhage | en_HK |
dc.title | Elevated blood pressure aggravates intracerebral hemorrhage-induced brain injury | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | So, KF:hrmaskf@hkucc.hku.hk | en_HK |
dc.identifier.email | Cheung, RTF:rtcheung@hku.hk | en_HK |
dc.identifier.authority | So, KF=rp00329 | en_HK |
dc.identifier.authority | Cheung, RTF=rp00434 | en_HK |
dc.description.nature | published_or_final_version | en_US |
dc.identifier.doi | 10.1089/neu.2010.1680 | en_HK |
dc.identifier.pmid | 21988112 | - |
dc.identifier.pmcid | PMC3235342 | - |
dc.identifier.scopus | eid_2-s2.0-83455201126 | en_HK |
dc.identifier.hkuros | 202188 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-83455201126&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 28 | en_HK |
dc.identifier.issue | 12 | en_HK |
dc.identifier.spage | 2523 | en_HK |
dc.identifier.epage | 2534 | en_HK |
dc.identifier.eissn | 1557-9042 | - |
dc.identifier.isi | WOS:000298291600012 | - |
dc.publisher.place | United States | en_HK |
dc.relation.project | The effects of self-assembling peptide nanofiber scaffold (SAPNS) in a renovascular hypertensive (RVHT) rat model of intracerebral hemorrhage (ICH). Part I: establishment of an ICH model permitting clot aspiration and injection of SAPNS | - |
dc.relation.project | The effects of self-assembling peptide nanofiber scaffold (SAPNS) in a renovascular hypertensive (RVHT) rat model of intracerebral hemorrhage (ICH). Part II: evaluation of SAPNS in the RVHT rat model of ICH | - |
dc.relation.project | Transplantation of neural stem cells in a rat model of intracerebral hemorrhage | - |
dc.identifier.scopusauthorid | Sang, YH=54685193800 | en_HK |
dc.identifier.scopusauthorid | Su, HX=16317750200 | en_HK |
dc.identifier.scopusauthorid | Wu, WT=54685469200 | en_HK |
dc.identifier.scopusauthorid | So, KF=34668391300 | en_HK |
dc.identifier.scopusauthorid | Cheung, RTF=7202397498 | en_HK |
dc.customcontrol.immutable | jt 130313 | - |
dc.identifier.issnl | 0897-7151 | - |