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- Publisher Website: 10.1016/0165-4608(94)00153-3
- Scopus: eid_2-s2.0-0028904998
- PMID: 7697633
- WOS: WOS:A1995QQ23000011
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Article: Gene amplification elucidated by combined chromosomal microdissection and comparative genomic hybridization
Title | Gene amplification elucidated by combined chromosomal microdissection and comparative genomic hybridization |
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Authors | |
Issue Date | 1995 |
Publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergene |
Citation | Cancer Genetics And Cytogenetics, 1995, v. 80 n. 1, p. 55-59 How to Cite? |
Abstract | Gene amplification is an important manifestation of genetic instability in cancer. Recently, the study of gene amplification has been greatly facilitated by the development of the molecular cytogenetic techniques of comparative genomic hybridization and chromosome microdissection. We describe in this brief overview a combined approach using both techniques, which allows the identification of chromosomal regions of gone amplification and provides entry point clones for target gene identification. This molecular/cytogenetic approach consisting of chromosome microdissection and comparative genomic hybridization should be valuable in identifying novel amplified genes important in neoplastic development and progression. |
Persistent Identifier | http://hdl.handle.net/10722/150714 |
ISSN | 2012 Impact Factor: 1.929 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Liang, BC | en_US |
dc.contributor.author | Meltzer, PS | en_US |
dc.contributor.author | Guan, XY | en_US |
dc.contributor.author | Trent, JM | en_US |
dc.date.accessioned | 2012-06-26T06:09:07Z | - |
dc.date.available | 2012-06-26T06:09:07Z | - |
dc.date.issued | 1995 | en_US |
dc.identifier.citation | Cancer Genetics And Cytogenetics, 1995, v. 80 n. 1, p. 55-59 | en_US |
dc.identifier.issn | 0165-4608 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/150714 | - |
dc.description.abstract | Gene amplification is an important manifestation of genetic instability in cancer. Recently, the study of gene amplification has been greatly facilitated by the development of the molecular cytogenetic techniques of comparative genomic hybridization and chromosome microdissection. We describe in this brief overview a combined approach using both techniques, which allows the identification of chromosomal regions of gone amplification and provides entry point clones for target gene identification. This molecular/cytogenetic approach consisting of chromosome microdissection and comparative genomic hybridization should be valuable in identifying novel amplified genes important in neoplastic development and progression. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergene | en_US |
dc.relation.ispartof | Cancer Genetics and Cytogenetics | en_US |
dc.subject.mesh | Chromosomes | en_US |
dc.subject.mesh | Dna, Neoplasm | en_US |
dc.subject.mesh | Dissection - Methods | en_US |
dc.subject.mesh | Gene Amplification | en_US |
dc.subject.mesh | In Situ Hybridization, Fluorescence - Methods | en_US |
dc.subject.mesh | Nucleic Acid Hybridization | en_US |
dc.title | Gene amplification elucidated by combined chromosomal microdissection and comparative genomic hybridization | en_US |
dc.type | Article | en_US |
dc.identifier.email | Guan, XY:xyguan@hkucc.hku.hk | en_US |
dc.identifier.authority | Guan, XY=rp00454 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/0165-4608(94)00153-3 | en_US |
dc.identifier.pmid | 7697633 | - |
dc.identifier.scopus | eid_2-s2.0-0028904998 | en_US |
dc.identifier.volume | 80 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.spage | 55 | en_US |
dc.identifier.epage | 59 | en_US |
dc.identifier.isi | WOS:A1995QQ23000011 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Liang, BC=7202071001 | en_US |
dc.identifier.scopusauthorid | Meltzer, PS=7102464641 | en_US |
dc.identifier.scopusauthorid | Guan, XY=7201463221 | en_US |
dc.identifier.scopusauthorid | Trent, JM=7201692482 | en_US |
dc.identifier.issnl | 0165-4608 | - |