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Article: Pilot study on evaluation of any correlation between MR perfusion (Ktrans) and diffusion (apparent diffusion coefficient) parameters in brain tumors at 3 Tesla.
Title | Pilot study on evaluation of any correlation between MR perfusion (Ktrans) and diffusion (apparent diffusion coefficient) parameters in brain tumors at 3 Tesla. |
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Authors | |
Keywords | Permeability Dynamic contrast-enhanced MRI Diffusion-weighted imaging Brain tumor Blood-brain barrier Apparent diffusion coefficient |
Issue Date | 2012 |
Publisher | e-MED Ltd.. The Journal's web site is located at http://www.cancerimaging.org |
Citation | Cancer Imaging, 2012, v. 12 n. 1, p. 1-6 How to Cite? |
Abstract | Purpose: To assess any correlation of volume transfer constant (K trans) with apparent diffusion coefficient (ADC) in different brain tumor types at 3 T magnetic resonance (MR) imaging. Materials and methods: Thirteen patients with brain tumors (8 men, 5 women; mean age 54.6 ± 17.7 years) were enrolled in this retrospective study. All patients underwent dynamic contrast-enhanced T 1-weighted MR perfusion and diffusion-weighted imaging using a 3 T scanner. K trans was estimated by specially designed software. For each tumor, regions of interest (ROIs) were manually selected on corresponding K trans and ADC maps. Pearson correlation coefficients were obtained for maximum, mean and minimum values of K trans and ADC of all ROIs. Based on clinicopathologic results, the final diagnoses of patients were glioblastoma multiforme (3), low-grade to anaplastic gliomas (4), meningiomas (3) and metastatic tumors (3). Results: K trans(max) values were significantly inversely correlated with ADC(min) values (r=-0.536, P<0.001) and ADC(mean) values (r=-0.465, P<0.001). K trans(mean) and K trans(min) values were significantly inversely correlated with ADC(mean) (r=-0.228, P=0.038) and ADC(max) values (r=-0.355, P=0.001), respectively. Conclusion: We found that irrespective of brain tumor type, there is an inverse correlation between ADC and K trans. Our findings highlight an intricate relationship between vascular permeability and the tumor microenvironment, probably modulating and/or interacting with changes such as increased cellularity, ischemic insult and varying extracellular matrix composition. © 2012 International Cancer Imaging Society. |
Persistent Identifier | http://hdl.handle.net/10722/150927 |
ISSN | 2023 Impact Factor: 3.5 2023 SCImago Journal Rankings: 1.227 |
PubMed Central ID | |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chu, JP | en_HK |
dc.contributor.author | Mak, HKF | en_HK |
dc.contributor.author | Yau, KKW | en_HK |
dc.contributor.author | Zhang, L | en_HK |
dc.contributor.author | Tsang, J | en_HK |
dc.contributor.author | Chan, Q | en_HK |
dc.contributor.author | Leung, GKK | en_HK |
dc.date.accessioned | 2012-06-26T06:14:34Z | - |
dc.date.available | 2012-06-26T06:14:34Z | - |
dc.date.issued | 2012 | en_HK |
dc.identifier.citation | Cancer Imaging, 2012, v. 12 n. 1, p. 1-6 | en_HK |
dc.identifier.issn | 1740-5025 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/150927 | - |
dc.description.abstract | Purpose: To assess any correlation of volume transfer constant (K trans) with apparent diffusion coefficient (ADC) in different brain tumor types at 3 T magnetic resonance (MR) imaging. Materials and methods: Thirteen patients with brain tumors (8 men, 5 women; mean age 54.6 ± 17.7 years) were enrolled in this retrospective study. All patients underwent dynamic contrast-enhanced T 1-weighted MR perfusion and diffusion-weighted imaging using a 3 T scanner. K trans was estimated by specially designed software. For each tumor, regions of interest (ROIs) were manually selected on corresponding K trans and ADC maps. Pearson correlation coefficients were obtained for maximum, mean and minimum values of K trans and ADC of all ROIs. Based on clinicopathologic results, the final diagnoses of patients were glioblastoma multiforme (3), low-grade to anaplastic gliomas (4), meningiomas (3) and metastatic tumors (3). Results: K trans(max) values were significantly inversely correlated with ADC(min) values (r=-0.536, P<0.001) and ADC(mean) values (r=-0.465, P<0.001). K trans(mean) and K trans(min) values were significantly inversely correlated with ADC(mean) (r=-0.228, P=0.038) and ADC(max) values (r=-0.355, P=0.001), respectively. Conclusion: We found that irrespective of brain tumor type, there is an inverse correlation between ADC and K trans. Our findings highlight an intricate relationship between vascular permeability and the tumor microenvironment, probably modulating and/or interacting with changes such as increased cellularity, ischemic insult and varying extracellular matrix composition. © 2012 International Cancer Imaging Society. | en_HK |
dc.language | eng | en_US |
dc.publisher | e-MED Ltd.. The Journal's web site is located at http://www.cancerimaging.org | - |
dc.relation.ispartof | Cancer Imaging | en_HK |
dc.subject | Permeability | - |
dc.subject | Dynamic contrast-enhanced MRI | - |
dc.subject | Diffusion-weighted imaging | - |
dc.subject | Brain tumor | - |
dc.subject | Blood-brain barrier | - |
dc.subject | Apparent diffusion coefficient | - |
dc.subject.mesh | Tumor microenvironment | en_US |
dc.subject.mesh | Retrospective studies | en_US |
dc.subject.mesh | Perfusion | en_US |
dc.subject.mesh | Middle aged | en_US |
dc.subject.mesh | Meningioma - Blood Supply - Metabolism - Pathology | en_US |
dc.subject.mesh | Meningeal neoplasms - Blood supply - Metabolism - Pathology | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Ischemia - Pathology | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Glioma - Blood Supply - Metabolism - Pathology | en_US |
dc.subject.mesh | Glioblastoma - Blood supply - Metabolism - Pathology | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Extracellular matrix - Pathology | en_US |
dc.subject.mesh | Diffusion magnetic resonance imaging - Methods | en_US |
dc.subject.mesh | Diffusion | en_US |
dc.subject.mesh | Carcinoma - Blood supply - Metabolism - Pathology - Secondary | en_US |
dc.subject.mesh | Capillary permeability | en_US |
dc.subject.mesh | Brain neoplasms - Blood supply - Metabolism - Pathology - Secondary | en_US |
dc.subject.mesh | Body water | en_US |
dc.subject.mesh | Blood-brain barrier | en_US |
dc.subject.mesh | Aged, 80 and over | en_US |
dc.subject.mesh | Aged | en_US |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Adrenal cortex hormones - Therapeutic use | en_US |
dc.title | Pilot study on evaluation of any correlation between MR perfusion (Ktrans) and diffusion (apparent diffusion coefficient) parameters in brain tumors at 3 Tesla. | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Mak, HKF: makkf@hkucc.hku.hk | en_US |
dc.identifier.email | Leung, GKK: gilberto@hku.hk | en_US |
dc.identifier.authority | Mak, HKF=rp00533 | en_US |
dc.identifier.authority | Leung, GKK=rp00522 | en_US |
dc.description.nature | link_to_OA_fulltext | en_US |
dc.identifier.doi | 10.1102/1470-7330.2012.0001 | en_HK |
dc.identifier.pmid | 22275724 | - |
dc.identifier.pmcid | PMC3266579 | - |
dc.identifier.scopus | eid_2-s2.0-84863043940 | en_HK |
dc.identifier.hkuros | 209519 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-84857016072&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 12 | en_HK |
dc.identifier.issue | 1 | en_HK |
dc.identifier.spage | 1 | en_HK |
dc.identifier.epage | 6 | en_HK |
dc.identifier.eissn | 1470-7330 | - |
dc.identifier.isi | WOS:000305506400001 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.scopusauthorid | Leung, GKK=37077484300 | en_US |
dc.identifier.scopusauthorid | Chan, Q=54985929800 | en_US |
dc.identifier.scopusauthorid | Tsang, J=35141929400 | en_US |
dc.identifier.scopusauthorid | Zhang, L=54984556400 | en_US |
dc.identifier.scopusauthorid | Yau, KKW=7101941425 | en_US |
dc.identifier.scopusauthorid | Mak, HKF=7004699149 | en_US |
dc.identifier.scopusauthorid | Chu, JP=54987353300 | en_US |
dc.identifier.issnl | 1470-7330 | - |