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Conference Paper: Activation of lytic cycle of Epstein-Barr Virus by suberoylanilide hydroxamic acid affects apoptosis and tumor growth suppression of nasopharyngeal carcinoma
| Title | Activation of lytic cycle of Epstein-Barr Virus by suberoylanilide hydroxamic acid affects apoptosis and tumor growth suppression of nasopharyngeal carcinoma |
|---|---|
| Authors | |
| Issue Date | 2012 |
| Publisher | American Association for Cancer Research. |
| Citation | The Annual Meeting of the American Association for Cancer Research (AACR 2012), Chicago, IL., 31 March-4 April 2012. How to Cite? |
| Abstract | Nasopharyngeal carcinoma (NPC) is strongly associated with Epstein-Barr virus (EBV). We examined the in vitro and in vivo effects of suberoylanilide hydroxamic acid (SAHA), a FDA-approved histone deacetylase inhibitor, on EBV lytic cycle induction in NPC and investigated the cellular consequences. Micromolar concentrations of SAHA potently induced EBV lytic cycle with replication of EBV DNA, expression of immediate early (Zta and Rta), early (BMRF1) and late (gp350) lytic proteins and production of infectious viral particles in ... |
| Description | Poster Session 31 - Inhibitors of Epigenetic and Gene Regulatory Targets: abstract no. 4715 |
| Persistent Identifier | http://hdl.handle.net/10722/153128 |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Chiang, AKS | en_US |
| dc.contributor.author | Hui, KF | en_US |
| dc.date.accessioned | 2012-07-16T09:57:35Z | - |
| dc.date.available | 2012-07-16T09:57:35Z | - |
| dc.date.issued | 2012 | en_US |
| dc.identifier.citation | The Annual Meeting of the American Association for Cancer Research (AACR 2012), Chicago, IL., 31 March-4 April 2012. | en_US |
| dc.identifier.uri | http://hdl.handle.net/10722/153128 | - |
| dc.description | Poster Session 31 - Inhibitors of Epigenetic and Gene Regulatory Targets: abstract no. 4715 | - |
| dc.description.abstract | Nasopharyngeal carcinoma (NPC) is strongly associated with Epstein-Barr virus (EBV). We examined the in vitro and in vivo effects of suberoylanilide hydroxamic acid (SAHA), a FDA-approved histone deacetylase inhibitor, on EBV lytic cycle induction in NPC and investigated the cellular consequences. Micromolar concentrations of SAHA potently induced EBV lytic cycle with replication of EBV DNA, expression of immediate early (Zta and Rta), early (BMRF1) and late (gp350) lytic proteins and production of infectious viral particles in ... | - |
| dc.language | eng | en_US |
| dc.publisher | American Association for Cancer Research. | - |
| dc.relation.ispartof | Annual Meeting of the American Association for Cancer Research, AACR 2012 | en_US |
| dc.title | Activation of lytic cycle of Epstein-Barr Virus by suberoylanilide hydroxamic acid affects apoptosis and tumor growth suppression of nasopharyngeal carcinoma | en_US |
| dc.type | Conference_Paper | en_US |
| dc.identifier.email | Chiang, AKS: chiangak@hku.hk | en_US |
| dc.identifier.email | Hui, KF: kfhui@hku.hk | en_US |
| dc.identifier.authority | Chiang, AKS=rp00403 | en_US |
| dc.description.nature | link_to_OA_fulltext | - |
| dc.identifier.hkuros | 200659 | en_US |
| dc.publisher.place | United States | - |
| dc.description.other | The Annual Meeting of the American Association for Cancer Research (AACR 2012), Chicago, IL., 31 March-4 April 2012. | - |