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- Publisher Website: 10.1002/jbm.a.20089
- Scopus: eid_2-s2.0-1342301648
- PMID: 14762931
- WOS: WOS:000189011800013
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Article: In vivo cancellous bone remodeling on a Strontium-containing hydroxyapatite (Sr-HA) bioactive cement
Title | In vivo cancellous bone remodeling on a Strontium-containing hydroxyapatite (Sr-HA) bioactive cement |
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Authors | |
Keywords | Bioactive bone cement Bone formation Bone remodeling Osteoconductive Strontium-containing hydroxyapatite |
Issue Date | 2004 |
Citation | Journal Of Biomedical Materials Research - Part A, 2004, v. 68 n. 3, p. 513-521 How to Cite? |
Abstract | The purpose of this study was to investigate the in vivo bone response to the strontium-containing hydroxyapatite (Sr-HA) bioactive bone cement injected into the cancellous bone. Sr-HA cement was injected into the iliac crest of rabbits for 1, 3, and 6 months. Active bone formation and remodeling were observed after 1 month. Newly formed bone was observed to grow onto the bone cement after 3 months. Thick osteoid layer with osteoblasts formed along the bone and guided over the bone cement surface reflected the stimulating effect of Sr-HA. From scanning electron microscopy (SEM) and energy-dispersive X-ray (EDX) analysis, high calcium and phosphorus levels were detected at the interface with a thick layer of 70 μm in width, and fusion of Sr-HA with the bone was observed. Blood vessels were found developing in remodeling sites. The affinity of bone on Sr-HA cement was increased from 73.55 ± 3.50% after 3 months up to 85.15 ± 2.74% after 6 months (p < 0.01). In contrast to Sr-HA cement, poly(methyl methacrylate) (PMMA) bone cement was neither osteoconductive nor bioresorbable. Results show that the Sr-HA cement is biocompatible and osteoconductive, which is suitable for use in treating osteoporotic vertebral fractures. © 2003 Wiley Periodicals, Inc. |
Persistent Identifier | http://hdl.handle.net/10722/154292 |
ISSN | 2019 SCImago Journal Rankings: 0.125 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Wong, CT | en_HK |
dc.contributor.author | Lu, WW | en_HK |
dc.contributor.author | Chan, WK | en_HK |
dc.contributor.author | Cheung, KMC | en_HK |
dc.contributor.author | Luk, KDK | en_HK |
dc.contributor.author | Lu, DS | en_HK |
dc.contributor.author | Rabie, ABM | en_HK |
dc.contributor.author | Deng, LF | en_HK |
dc.contributor.author | Leong, JCY | en_HK |
dc.date.accessioned | 2012-08-08T08:24:26Z | - |
dc.date.available | 2012-08-08T08:24:26Z | - |
dc.date.issued | 2004 | en_HK |
dc.identifier.citation | Journal Of Biomedical Materials Research - Part A, 2004, v. 68 n. 3, p. 513-521 | en_HK |
dc.identifier.issn | 0021-9304 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/154292 | - |
dc.description.abstract | The purpose of this study was to investigate the in vivo bone response to the strontium-containing hydroxyapatite (Sr-HA) bioactive bone cement injected into the cancellous bone. Sr-HA cement was injected into the iliac crest of rabbits for 1, 3, and 6 months. Active bone formation and remodeling were observed after 1 month. Newly formed bone was observed to grow onto the bone cement after 3 months. Thick osteoid layer with osteoblasts formed along the bone and guided over the bone cement surface reflected the stimulating effect of Sr-HA. From scanning electron microscopy (SEM) and energy-dispersive X-ray (EDX) analysis, high calcium and phosphorus levels were detected at the interface with a thick layer of 70 μm in width, and fusion of Sr-HA with the bone was observed. Blood vessels were found developing in remodeling sites. The affinity of bone on Sr-HA cement was increased from 73.55 ± 3.50% after 3 months up to 85.15 ± 2.74% after 6 months (p < 0.01). In contrast to Sr-HA cement, poly(methyl methacrylate) (PMMA) bone cement was neither osteoconductive nor bioresorbable. Results show that the Sr-HA cement is biocompatible and osteoconductive, which is suitable for use in treating osteoporotic vertebral fractures. © 2003 Wiley Periodicals, Inc. | en_HK |
dc.language | eng | en_US |
dc.relation.ispartof | Journal of Biomedical Materials Research - Part A | en_HK |
dc.rights | Journal of Biomedical Materials Research Part A. Copyright © John Wiley & Sons, Inc. | - |
dc.subject | Bioactive bone cement | en_HK |
dc.subject | Bone formation | en_HK |
dc.subject | Bone remodeling | en_HK |
dc.subject | Osteoconductive | en_HK |
dc.subject | Strontium-containing hydroxyapatite | en_HK |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Biodegradation, Environmental | en_US |
dc.subject.mesh | Bone Cements - Chemistry - Pharmacology - Standards | en_US |
dc.subject.mesh | Bone Remodeling - Drug Effects | en_US |
dc.subject.mesh | Durapatite | en_US |
dc.subject.mesh | Ilium | en_US |
dc.subject.mesh | Materials Testing | en_US |
dc.subject.mesh | Neovascularization, Physiologic - Drug Effects | en_US |
dc.subject.mesh | Osteoblasts - Cytology - Drug Effects | en_US |
dc.subject.mesh | Polymethyl Methacrylate | en_US |
dc.subject.mesh | Rabbits | en_US |
dc.subject.mesh | Strontium | en_US |
dc.title | In vivo cancellous bone remodeling on a Strontium-containing hydroxyapatite (Sr-HA) bioactive cement | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Lu, WW: wwlu@hku.hk | en_HK |
dc.identifier.email | Chan, WK: waichan@hku.hk | en_HK |
dc.identifier.email | Cheung, KMC: cheungmc@hku.hk | en_HK |
dc.identifier.email | Luk, KDK: hcm21000@hku.hk | en_HK |
dc.identifier.email | Rabie, ABM: rabie@hku.hk | en_HK |
dc.identifier.authority | Lu, WW=rp00411 | en_HK |
dc.identifier.authority | Chan, WK=rp00667 | en_HK |
dc.identifier.authority | Cheung, KMC=rp00387 | en_HK |
dc.identifier.authority | Luk, KDK=rp00333 | en_HK |
dc.identifier.authority | Rabie, ABM=rp00029 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1002/jbm.a.20089 | - |
dc.identifier.pmid | 14762931 | - |
dc.identifier.scopus | eid_2-s2.0-1342301648 | en_HK |
dc.identifier.hkuros | 87297 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-1342301648&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 68 | en_HK |
dc.identifier.issue | 3 | en_HK |
dc.identifier.spage | 513 | en_HK |
dc.identifier.epage | 521 | en_HK |
dc.identifier.isi | WOS:000189011800013 | - |
dc.identifier.scopusauthorid | Wong, CT=7404954512 | en_HK |
dc.identifier.scopusauthorid | Lu, WW=7404215221 | en_HK |
dc.identifier.scopusauthorid | Chan, WK=13310083000 | en_HK |
dc.identifier.scopusauthorid | Cheung, KMC=7402406754 | en_HK |
dc.identifier.scopusauthorid | Luk, KDK=7201921573 | en_HK |
dc.identifier.scopusauthorid | Lu, DS=7403079533 | en_HK |
dc.identifier.scopusauthorid | Rabie, ABM=7007172734 | en_HK |
dc.identifier.scopusauthorid | Deng, LF=7202007494 | en_HK |
dc.identifier.scopusauthorid | Leong, JCY=35560782200 | en_HK |
dc.identifier.issnl | 0021-9304 | - |