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- Publisher Website: 10.1016/j.antiviral.2003.09.009
- Scopus: eid_2-s2.0-0842311270
- PMID: 15168796
- WOS: WOS:000189131000003
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Article: Identification of a novel CD4i human monoclonal antibody Fab that neutralizes HIV-1 primary isolates from different clades
| Title | Identification of a novel CD4i human monoclonal antibody Fab that neutralizes HIV-1 primary isolates from different clades |
|---|---|
| Authors | |
| Keywords | Antibody gp120 HIV Inhibitors Phage display Vaccines |
| Issue Date | 2004 |
| Publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/antiviral |
| Citation | Antiviral Research, 2004, v. 61 n. 3, p. 161-164 How to Cite? |
| Abstract | A new human monoclonal antibody (hmAb), designated m16, was selected by sequential antigen panning (SAP) of a human phage display library against recombinant soluble HIV-1 envelope glycoproteins (Envs) (gp140s) and their complexes with soluble CD4. It bound with high (nM) affinity to gp120 and gp140; the binding was further enhanced by interactions of the Envs with CD4. m16 inhibited cell fusion mediated by the Envs of 9 HIV-1 isolates from clades A, B, E and G with potency on average comparable to that of the broadly neutralizing human monoclonal antibody Fab X5. The identification of a new hmAb with broad neutralizing activity that exhibits differential inhibitory profile suggests a potential for its use as a component of anti-HIV-1 treatments. |
| Persistent Identifier | http://hdl.handle.net/10722/157381 |
| ISSN | 2023 Impact Factor: 4.5 2023 SCImago Journal Rankings: 1.500 |
| ISI Accession Number ID | |
| References |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Zhang, MY | en_US |
| dc.contributor.author | Shu, Y | en_US |
| dc.contributor.author | Sidorov, I | en_US |
| dc.contributor.author | Dimitrov, DS | en_US |
| dc.date.accessioned | 2012-08-08T08:49:29Z | - |
| dc.date.available | 2012-08-08T08:49:29Z | - |
| dc.date.issued | 2004 | en_US |
| dc.identifier.citation | Antiviral Research, 2004, v. 61 n. 3, p. 161-164 | en_US |
| dc.identifier.issn | 0166-3542 | en_US |
| dc.identifier.uri | http://hdl.handle.net/10722/157381 | - |
| dc.description.abstract | A new human monoclonal antibody (hmAb), designated m16, was selected by sequential antigen panning (SAP) of a human phage display library against recombinant soluble HIV-1 envelope glycoproteins (Envs) (gp140s) and their complexes with soluble CD4. It bound with high (nM) affinity to gp120 and gp140; the binding was further enhanced by interactions of the Envs with CD4. m16 inhibited cell fusion mediated by the Envs of 9 HIV-1 isolates from clades A, B, E and G with potency on average comparable to that of the broadly neutralizing human monoclonal antibody Fab X5. The identification of a new hmAb with broad neutralizing activity that exhibits differential inhibitory profile suggests a potential for its use as a component of anti-HIV-1 treatments. | en_US |
| dc.language | eng | en_US |
| dc.publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/antiviral | en_US |
| dc.relation.ispartof | Antiviral Research | en_US |
| dc.subject | Antibody | - |
| dc.subject | gp120 | - |
| dc.subject | HIV | - |
| dc.subject | Inhibitors | - |
| dc.subject | Phage display | - |
| dc.subject | Vaccines | - |
| dc.subject.mesh | Antibodies, Monoclonal - Immunology | en_US |
| dc.subject.mesh | Antibody Affinity | en_US |
| dc.subject.mesh | Antigens, Cd4 - Immunology | en_US |
| dc.subject.mesh | Cell Fusion | en_US |
| dc.subject.mesh | Gene Products, Env - Immunology | en_US |
| dc.subject.mesh | Genotype | en_US |
| dc.subject.mesh | Hiv Antibodies - Immunology | en_US |
| dc.subject.mesh | Hiv Antigens - Immunology | en_US |
| dc.subject.mesh | Hiv Envelope Protein Gp120 - Immunology | en_US |
| dc.subject.mesh | Hiv-1 - Genetics - Immunology | en_US |
| dc.subject.mesh | Humans | en_US |
| dc.subject.mesh | Immunoglobulin Fab Fragments - Immunology | en_US |
| dc.subject.mesh | Neutralization Tests | en_US |
| dc.subject.mesh | Peptide Library | en_US |
| dc.subject.mesh | Protein Binding | en_US |
| dc.subject.mesh | Recombinant Proteins - Immunology | en_US |
| dc.subject.mesh | Env Gene Products, Human Immunodeficiency Virus | en_US |
| dc.title | Identification of a novel CD4i human monoclonal antibody Fab that neutralizes HIV-1 primary isolates from different clades | en_US |
| dc.type | Article | en_US |
| dc.identifier.email | Zhang, MY:zhangmy@hku.hk | en_US |
| dc.identifier.authority | Zhang, MY=rp01409 | en_US |
| dc.description.nature | link_to_subscribed_fulltext | en_US |
| dc.identifier.doi | 10.1016/j.antiviral.2003.09.009 | en_US |
| dc.identifier.pmid | 15168796 | - |
| dc.identifier.scopus | eid_2-s2.0-0842311270 | en_US |
| dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0842311270&selection=ref&src=s&origin=recordpage | en_US |
| dc.identifier.volume | 61 | en_US |
| dc.identifier.issue | 3 | en_US |
| dc.identifier.spage | 161 | en_US |
| dc.identifier.epage | 164 | en_US |
| dc.identifier.isi | WOS:000189131000003 | - |
| dc.publisher.place | Netherlands | en_US |
| dc.identifier.scopusauthorid | Zhang, MY=35316639300 | en_US |
| dc.identifier.scopusauthorid | Shu, Y=7103239429 | en_US |
| dc.identifier.scopusauthorid | Sidorov, I=7005186545 | en_US |
| dc.identifier.scopusauthorid | Dimitrov, DS=7202564539 | en_US |
| dc.identifier.issnl | 0166-3542 | - |