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Article: Antibody responses against SARS coronavirus are correlated with disease outcome of infected individuals

TitleAntibody responses against SARS coronavirus are correlated with disease outcome of infected individuals
Authors
Zhang, LZhang, FYu, WHe, TYu, JYi, CEBa, LLi, WFarzan, MChen, ZYuen, KYHo, D
KeywordsDisease progression
Neutralizing antibody
SARS
Vaccine
Issue Date2006
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/32763
Citation
Journal Of Medical Virology, 2006, v. 78 n. 1, p. 1-8 How to Cite?
DOI: http://dx.doi.org/10.1002/jmv.20499
AbstractMost of the SARS-CoV-infected patients spontaneously recovered without clinical intervention while a small percentage succumbed to the disease. Here, we characterized temporal changes in N protein-specific and S glycoprotein-specific neutralizing antibody (Nab) responses in infected patients who have either recovered from or succumbed to SARS-CoV infection. Recovered patients were found to have higher and sustainable levels of both N protein-specific and S glycoprotein-specific Nab responses, suggesting that antibody responses likely play an important role in determining the ultimate disease outcome of SARS-CoV-infected patients. © 2005 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/157427
ISSN
0146-6615
2023 Impact Factor: 6.8
2023 SCImago Journal Rankings: 1.560
ISI Accession Number ID
WOS:000233738800001
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorZhang, Len_US
dc.contributor.authorZhang, Fen_US
dc.contributor.authorYu, Wen_US
dc.contributor.authorHe, Ten_US
dc.contributor.authorYu, Jen_US
dc.contributor.authorYi, CEen_US
dc.contributor.authorBa, Len_US
dc.contributor.authorLi, Wen_US
dc.contributor.authorFarzan, Men_US
dc.contributor.authorChen, Zen_US
dc.contributor.authorYuen, KYen_US
dc.contributor.authorHo, Den_US
dc.date.accessioned2012-08-08T08:49:52Z-
dc.date.available2012-08-08T08:49:52Z-
dc.date.issued2006en_US
dc.identifier.citationJournal Of Medical Virology, 2006, v. 78 n. 1, p. 1-8en_US
dc.identifier.issn0146-6615en_US
dc.identifier.urihttp://hdl.handle.net/10722/157427-
dc.description.abstractMost of the SARS-CoV-infected patients spontaneously recovered without clinical intervention while a small percentage succumbed to the disease. Here, we characterized temporal changes in N protein-specific and S glycoprotein-specific neutralizing antibody (Nab) responses in infected patients who have either recovered from or succumbed to SARS-CoV infection. Recovered patients were found to have higher and sustainable levels of both N protein-specific and S glycoprotein-specific Nab responses, suggesting that antibody responses likely play an important role in determining the ultimate disease outcome of SARS-CoV-infected patients. © 2005 Wiley-Liss, Inc.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/32763en_US
dc.relation.ispartofJournal of Medical Virologyen_US
dc.subjectDisease progression-
dc.subjectNeutralizing antibody-
dc.subjectSARS-
dc.subjectVaccine-
dc.subject.meshAntibodies, Viral - Blood - Immunologyen_US
dc.subject.meshDisease Progressionen_US
dc.subject.meshHumansen_US
dc.subject.meshMembrane Glycoproteins - Immunologyen_US
dc.subject.meshNeutralization Testsen_US
dc.subject.meshNucleocapsid Proteins - Immunologyen_US
dc.subject.meshSars Virus - Immunologyen_US
dc.subject.meshSevere Acute Respiratory Syndrome - Immunology - Physiopathologyen_US
dc.subject.meshViral Envelope Proteins - Immunologyen_US
dc.titleAntibody responses against SARS coronavirus are correlated with disease outcome of infected individualsen_US
dc.typeArticleen_US
dc.identifier.emailChen, Z:zchenai@hkucc.hku.hken_US
dc.identifier.emailYuen, KY:kyyuen@hkucc.hku.hken_US
dc.identifier.authorityChen, Z=rp00243en_US
dc.identifier.authorityYuen, KY=rp00366en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/jmv.20499en_US
dc.identifier.pmid16299724-
dc.identifier.scopuseid_2-s2.0-28944441428en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-28944441428&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume78en_US
dc.identifier.issue1en_US
dc.identifier.spage1en_US
dc.identifier.epage8en_US
dc.identifier.isiWOS:000233738800001-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridZhang, L=8783285300en_US
dc.identifier.scopusauthoridZhang, F=10640508100en_US
dc.identifier.scopusauthoridYu, W=7403914045en_US
dc.identifier.scopusauthoridHe, T=16935084000en_US
dc.identifier.scopusauthoridYu, J=7405525088en_US
dc.identifier.scopusauthoridYi, CE=8557032800en_US
dc.identifier.scopusauthoridBa, L=8557032300en_US
dc.identifier.scopusauthoridLi, W=7501793921en_US
dc.identifier.scopusauthoridFarzan, M=7003535041en_US
dc.identifier.scopusauthoridChen, Z=35271180800en_US
dc.identifier.scopusauthoridYuen, KY=36078079100en_US
dc.identifier.scopusauthoridHo, D=7402971998en_US
dc.identifier.issnl0146-6615-

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