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Article: Multiple-site DNA vaccination enhances immune responses in mice

TitleMultiple-site DNA vaccination enhances immune responses in mice
Authors
Gardiner, DFHuang, YBasu, SLeung, LSong, YChen, ZHo, DD
KeywordsDNA vaccine
Dose-sparing
Multiple-site vaccination
Issue Date2006
PublisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/vaccine
Citation
Vaccine, 2006, v. 24 n. 3, p. 287-292 How to Cite?
DOI: http://dx.doi.org/10.1016/j.vaccine.2005.07.075
AbstractIntramuscular delivery of plasmid DNA encoding vaccine antigens induces systemic immune responses in small animals but is less effective in inducing strong responses in larger animals species. We investigated if anatomic distribution of DNA could enhance responses to decreasing DNA doses. We show that anatomic distribution of low-dose DNA improves cell-mediated and humoral immune responses in mice. Anatomic distribution of low-dose DNA provided a dose-sparing effect for both cell-mediated immunity and humoral responses. Enhanced systemic responses correlate directly with recruitment of antigen-specific CD8+ T-cells in the regional lymph nodes. These results have implications for DNA vaccination in humans. © 2005 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/157428
ISSN
0264-410X
2023 Impact Factor: 4.5
2023 SCImago Journal Rankings: 1.342
ISI Accession Number ID
WOS:000234936300009
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorGardiner, DFen_US
dc.contributor.authorHuang, Yen_US
dc.contributor.authorBasu, Sen_US
dc.contributor.authorLeung, Len_US
dc.contributor.authorSong, Yen_US
dc.contributor.authorChen, Zen_US
dc.contributor.authorHo, DDen_US
dc.date.accessioned2012-08-08T08:49:53Z-
dc.date.available2012-08-08T08:49:53Z-
dc.date.issued2006en_US
dc.identifier.citationVaccine, 2006, v. 24 n. 3, p. 287-292en_US
dc.identifier.issn0264-410Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/157428-
dc.description.abstractIntramuscular delivery of plasmid DNA encoding vaccine antigens induces systemic immune responses in small animals but is less effective in inducing strong responses in larger animals species. We investigated if anatomic distribution of DNA could enhance responses to decreasing DNA doses. We show that anatomic distribution of low-dose DNA improves cell-mediated and humoral immune responses in mice. Anatomic distribution of low-dose DNA provided a dose-sparing effect for both cell-mediated immunity and humoral responses. Enhanced systemic responses correlate directly with recruitment of antigen-specific CD8+ T-cells in the regional lymph nodes. These results have implications for DNA vaccination in humans. © 2005 Elsevier Ltd. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/vaccineen_US
dc.relation.ispartofVaccineen_US
dc.subjectDNA vaccine-
dc.subjectDose-sparing-
dc.subjectMultiple-site vaccination-
dc.subject.meshAnimalsen_US
dc.subject.meshCd8-Positive T-Lymphocytes - Immunologyen_US
dc.subject.meshCytokines - Biosynthesisen_US
dc.subject.meshDose-Response Relationship, Immunologicen_US
dc.subject.meshEnzyme-Linked Immunosorbent Assayen_US
dc.subject.meshImmunity, Cellular - Drug Effectsen_US
dc.subject.meshInjections, Intramuscularen_US
dc.subject.meshInterferon-Gamma - Immunologyen_US
dc.subject.meshLymph Nodes - Cytology - Immunologyen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred Balb Cen_US
dc.subject.meshVaccinationen_US
dc.subject.meshVaccines, Dna - Immunology - Pharmacologyen_US
dc.subject.meshVaccines, Subunit - Immunologyen_US
dc.titleMultiple-site DNA vaccination enhances immune responses in miceen_US
dc.typeArticleen_US
dc.identifier.emailChen, Z:zchenai@hkucc.hku.hken_US
dc.identifier.authorityChen, Z=rp00243en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.vaccine.2005.07.075en_US
dc.identifier.pmid16137804-
dc.identifier.scopuseid_2-s2.0-29044437924en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-29044437924&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume24en_US
dc.identifier.issue3en_US
dc.identifier.spage287en_US
dc.identifier.epage292en_US
dc.identifier.isiWOS:000234936300009-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridGardiner, DF=7101800882en_US
dc.identifier.scopusauthoridHuang, Y=7501575029en_US
dc.identifier.scopusauthoridBasu, S=9943541500en_US
dc.identifier.scopusauthoridLeung, L=9943699600en_US
dc.identifier.scopusauthoridSong, Y=10141178900en_US
dc.identifier.scopusauthoridChen, Z=35271180800en_US
dc.identifier.scopusauthoridHo, DD=7402971998en_US
dc.identifier.issnl0264-410X-

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