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Conference Paper: Hypertensive mice with over-expression of endothelin-1 show hyperactivity, impaired sensorimotor gating, mild cognitive deficit and cerebral vascular oxidative stress
Title | Hypertensive mice with over-expression of endothelin-1 show hyperactivity, impaired sensorimotor gating, mild cognitive deficit and cerebral vascular oxidative stress |
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Authors | |
Issue Date | 2010 |
Publisher | The Federation of European Neuroscience Societies (FENS). |
Citation | The 7th FENS Forum of European Neuroscience, Amsterdam, The Netherlands, 3-7 July 2010. In FENS Abstract, 2010, v. 5, abstract no. 204.9 How to Cite? |
Abstract | Previous studies showed that endothelin-1 (ET-1), a potent vasoconstrictor, is increased in the
cerebrospinal fluid of dementia patients, suggesting that ET-1 might contribute to the impairment of
cognitive function. This is supported by the observation that injection of ET-1 into the hippocampus of
aged animals caused neuronal death, accompanied by learning and memory deficit. Since short-term
effects of exogenously administered ET-1 may not stimulate the pathophysiological increase of ET-1,
we examined the behavior of transgenic (TET-1) mice that overexpress ET-1 specifically in the
endothelial cells. The behavioral changes and cognitive function were investigated in young (5-6
months) and aged (21-23 months) TET-1 mice under normal rearing conditions. Compared to the
age-matched non-transgenic mice, the aged TET-1 mice displayed significantly higher locomotor
activity in open field test, impairment in sensorimotor gating in pre-pulse inhibition of the acoustic
startle response test, and a trend of spatial learning and memory deficit in Morris water maze test.
The aged TET-1 mice also showed increased expression of heat-shock protein 70 (Hsp-70), hypoxia
induced factor-1 alpha (HIF-1 alpha) and gp91phox, a subunit of NADPH oxidase, in the endothelial
cells of cerebral vessels of the prefrontal cortex, suggesting that over-expression of endothelial ET-1
induces oxidative stress. In addition, glutamate expression was also increased in the prefrontal cortex
of the aged TET-1 mice, suggesting that glutamate neurotransmission was also affected. These
changes might account for the hyperactivity, impaired sensorimotor gating and mild cognitive deficit
due to over-expression of ET-1 in the cerebrovascular endothelial cells. |
Persistent Identifier | http://hdl.handle.net/10722/161592 |
DC Field | Value | Language |
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dc.contributor.author | Zhang, X | - |
dc.contributor.author | Chung, SSM | - |
dc.contributor.author | Chung, SK | - |
dc.date.accessioned | 2012-09-03T06:24:49Z | - |
dc.date.available | 2012-09-03T06:24:49Z | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | The 7th FENS Forum of European Neuroscience, Amsterdam, The Netherlands, 3-7 July 2010. In FENS Abstract, 2010, v. 5, abstract no. 204.9 | - |
dc.identifier.uri | http://hdl.handle.net/10722/161592 | - |
dc.description.abstract | Previous studies showed that endothelin-1 (ET-1), a potent vasoconstrictor, is increased in the cerebrospinal fluid of dementia patients, suggesting that ET-1 might contribute to the impairment of cognitive function. This is supported by the observation that injection of ET-1 into the hippocampus of aged animals caused neuronal death, accompanied by learning and memory deficit. Since short-term effects of exogenously administered ET-1 may not stimulate the pathophysiological increase of ET-1, we examined the behavior of transgenic (TET-1) mice that overexpress ET-1 specifically in the endothelial cells. The behavioral changes and cognitive function were investigated in young (5-6 months) and aged (21-23 months) TET-1 mice under normal rearing conditions. Compared to the age-matched non-transgenic mice, the aged TET-1 mice displayed significantly higher locomotor activity in open field test, impairment in sensorimotor gating in pre-pulse inhibition of the acoustic startle response test, and a trend of spatial learning and memory deficit in Morris water maze test. The aged TET-1 mice also showed increased expression of heat-shock protein 70 (Hsp-70), hypoxia induced factor-1 alpha (HIF-1 alpha) and gp91phox, a subunit of NADPH oxidase, in the endothelial cells of cerebral vessels of the prefrontal cortex, suggesting that over-expression of endothelial ET-1 induces oxidative stress. In addition, glutamate expression was also increased in the prefrontal cortex of the aged TET-1 mice, suggesting that glutamate neurotransmission was also affected. These changes might account for the hyperactivity, impaired sensorimotor gating and mild cognitive deficit due to over-expression of ET-1 in the cerebrovascular endothelial cells. | - |
dc.language | eng | - |
dc.publisher | The Federation of European Neuroscience Societies (FENS). | - |
dc.relation.ispartof | FENS Abstract | - |
dc.title | Hypertensive mice with over-expression of endothelin-1 show hyperactivity, impaired sensorimotor gating, mild cognitive deficit and cerebral vascular oxidative stress | en_US |
dc.type | Conference_Paper | en_US |
dc.identifier.email | Chung, SSM: smchung@hkucc.hku.hk | - |
dc.identifier.email | Chung, SK: skchung@hkucc.hku.hk | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.hkuros | 184964 | - |
dc.identifier.volume | 5 | - |
dc.publisher.place | The Netherlands | - |
dc.description.other | 7th FENS Forum of European Neuroscience, Amsterdam, The Netherlands, 3-7 July 2010. In FENS Abstract, 2010, v. 5, p. Abstract no. 204.9 | - |