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Article: Effect of cimetidine on gonadal function in man

TitleEffect of cimetidine on gonadal function in man
Authors
Wang, CLai, CLLam, KCYeung, KK
Issue Date1982
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJCP
Citation
British Journal Of Clinical Pharmacology, 1982, v. 13 n. 6, p. 791-794 How to Cite?
DOI: http://dx.doi.org/10.1111/j.1365-2125.1982.tb01867.x
AbstractTo study the effect of cimetidine on gonadal function in man, eleven male subjects with chronic duodenal ulcer were given cimetidine orally at a dosage of 1000 mg per day for 3 months and 400 mg nocte for the subsequent 3 months. Testosterone levels were found to be elevated during therapy when compared to pre- and post-treatment periods. Serum LH remained unchanged but FSH was increased during therapy. In five out of eleven subjects serum PRL levels were increased. Mean sperm count was lower during cimetidine therapy when compared with that after drug withdrawal. The motility and morphology of the spermatozoa were not affected.
Persistent Identifierhttp://hdl.handle.net/10722/161667
ISSN
0306-5251
2021 Impact Factor: 3.716
2020 SCImago Journal Rankings: 1.216
ISI Accession Number ID
WOS:A1982NU95800004

 

DC FieldValueLanguage
dc.contributor.authorWang, Cen_US
dc.contributor.authorLai, CLen_US
dc.contributor.authorLam, KCen_US
dc.contributor.authorYeung, KKen_US
dc.date.accessioned2012-09-05T05:13:41Z-
dc.date.available2012-09-05T05:13:41Z-
dc.date.issued1982en_US
dc.identifier.citationBritish Journal Of Clinical Pharmacology, 1982, v. 13 n. 6, p. 791-794en_US
dc.identifier.issn0306-5251en_US
dc.identifier.urihttp://hdl.handle.net/10722/161667-
dc.description.abstractTo study the effect of cimetidine on gonadal function in man, eleven male subjects with chronic duodenal ulcer were given cimetidine orally at a dosage of 1000 mg per day for 3 months and 400 mg nocte for the subsequent 3 months. Testosterone levels were found to be elevated during therapy when compared to pre- and post-treatment periods. Serum LH remained unchanged but FSH was increased during therapy. In five out of eleven subjects serum PRL levels were increased. Mean sperm count was lower during cimetidine therapy when compared with that after drug withdrawal. The motility and morphology of the spermatozoa were not affected.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJCPen_US
dc.relation.ispartofBritish Journal of Clinical Pharmacologyen_US
dc.subject.meshAdulten_US
dc.subject.meshCimetidine - Adverse Effects - Therapeutic Useen_US
dc.subject.meshDuodenal Ulcer - Drug Therapyen_US
dc.subject.meshFollicle Stimulating Hormone - Blooden_US
dc.subject.meshGuanidines - Adverse Effectsen_US
dc.subject.meshHormones - Blooden_US
dc.subject.meshHumansen_US
dc.subject.meshLuteinizing Hormone - Blooden_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshProlactin - Blooden_US
dc.subject.meshSemen - Cytologyen_US
dc.subject.meshSperm Counten_US
dc.subject.meshTestis - Drug Effectsen_US
dc.subject.meshTestosterone - Blooden_US
dc.titleEffect of cimetidine on gonadal function in manen_US
dc.typeArticleen_US
dc.identifier.emailLai, CL:hrmelcl@hku.hken_US
dc.identifier.authorityLai, CL=rp00314en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1365-2125.1982.tb01867.x-
dc.identifier.pmid6807332-
dc.identifier.scopuseid_2-s2.0-0020364614en_US
dc.identifier.volume13en_US
dc.identifier.issue6en_US
dc.identifier.spage791en_US
dc.identifier.epage794en_US
dc.identifier.isiWOS:A1982NU95800004-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridWang, C=7501631357en_US
dc.identifier.scopusauthoridLai, CL=7403086396en_US
dc.identifier.scopusauthoridLam, KC=7403657286en_US
dc.identifier.scopusauthoridYeung, KK=7202424973en_US
dc.identifier.issnl0306-5251-

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