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Article: Thyroid hormone regulates vasoactive intestinal peptide (VIP) mRNA levels in the rat anterior pituitary gland

TitleThyroid hormone regulates vasoactive intestinal peptide (VIP) mRNA levels in the rat anterior pituitary gland
Authors
Segerson, TPLam, KSLCacicedo, LMinamitani, NFink, JSLechan, RMReichlin, S
Issue Date1989
PublisherThe Endocrine Society. The Journal's web site is located at http://endo.endojournals.org
Citation
Endocrinology, 1989, v. 125 n. 4, p. 2221-2223 How to Cite?
DOI: http://dx.doi.org/10.1210/endo-125-4-2221
AbstractVasoactive intestinal peptide (VIP) is a secretagogue for pituitary prolactin, but the importance of this peptide in the normal control of prolactin secretion is unclear. Recent studies suggest VIP synthesis within the rat anterior pituitary. We have shown (Endocrinology 124:1077) that the content of rat pituitary VIP increases in hypothyroidism. To confirm in situ pituitary synthesis of VIP and determine whether thyroid hormone effects on pituitary VIP relate to changes in VIP mRNA, Northern and in situ hybridization analyses of VIP mRNA in rat pituitaries were performed. Northern hybridization demonstrated an RNA species from rat pituitary consistent with rat VIP mRNA. Hypothyroidsm increased the content of pituitary VIP mRNA, and replacement with 1-thyroxine prevented this increase. In situ hybridization showed multiple, widely-distributed hybridizing cells in pituitaries from hypothyroid animals. A distinct population of VIP-producing pituitary cells exists which may serve to modulate prolactin secretion in a paracrine or autocrine fashion.
Persistent Identifierhttp://hdl.handle.net/10722/161784
ISSN
0013-7227
2021 Impact Factor: 5.051
2020 SCImago Journal Rankings: 1.674
ISI Accession Number ID
WOS:A1989AT94200060

 

DC FieldValueLanguage
dc.contributor.authorSegerson, TPen_US
dc.contributor.authorLam, KSLen_US
dc.contributor.authorCacicedo, Len_US
dc.contributor.authorMinamitani, Nen_US
dc.contributor.authorFink, JSen_US
dc.contributor.authorLechan, RMen_US
dc.contributor.authorReichlin, Sen_US
dc.date.accessioned2012-09-05T05:14:56Z-
dc.date.available2012-09-05T05:14:56Z-
dc.date.issued1989en_US
dc.identifier.citationEndocrinology, 1989, v. 125 n. 4, p. 2221-2223en_US
dc.identifier.issn0013-7227en_US
dc.identifier.urihttp://hdl.handle.net/10722/161784-
dc.description.abstractVasoactive intestinal peptide (VIP) is a secretagogue for pituitary prolactin, but the importance of this peptide in the normal control of prolactin secretion is unclear. Recent studies suggest VIP synthesis within the rat anterior pituitary. We have shown (Endocrinology 124:1077) that the content of rat pituitary VIP increases in hypothyroidism. To confirm in situ pituitary synthesis of VIP and determine whether thyroid hormone effects on pituitary VIP relate to changes in VIP mRNA, Northern and in situ hybridization analyses of VIP mRNA in rat pituitaries were performed. Northern hybridization demonstrated an RNA species from rat pituitary consistent with rat VIP mRNA. Hypothyroidsm increased the content of pituitary VIP mRNA, and replacement with 1-thyroxine prevented this increase. In situ hybridization showed multiple, widely-distributed hybridizing cells in pituitaries from hypothyroid animals. A distinct population of VIP-producing pituitary cells exists which may serve to modulate prolactin secretion in a paracrine or autocrine fashion.en_US
dc.languageengen_US
dc.publisherThe Endocrine Society. The Journal's web site is located at http://endo.endojournals.orgen_US
dc.relation.ispartofEndocrinologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshMaleen_US
dc.subject.meshNucleic Acid Hybridizationen_US
dc.subject.meshPituitary Gland, Anterior - Metabolismen_US
dc.subject.meshRna, Messenger - Metabolismen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Strainsen_US
dc.subject.meshThyroid Hormones - Physiologyen_US
dc.subject.meshThyrotropin - Blooden_US
dc.subject.meshThyroxine - Pharmacologyen_US
dc.subject.meshVasoactive Intestinal Peptide - Geneticsen_US
dc.titleThyroid hormone regulates vasoactive intestinal peptide (VIP) mRNA levels in the rat anterior pituitary glanden_US
dc.typeArticleen_US
dc.identifier.emailLam, KSL:ksllam@hku.hken_US
dc.identifier.authorityLam, KSL=rp00343en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1210/endo-125-4-2221-
dc.identifier.pmid2791988-
dc.identifier.scopuseid_2-s2.0-0024427399en_US
dc.identifier.volume125en_US
dc.identifier.issue4en_US
dc.identifier.spage2221en_US
dc.identifier.epage2223en_US
dc.identifier.isiWOS:A1989AT94200060-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridSegerson, TP=55302295000en_US
dc.identifier.scopusauthoridLam, KSL=8082870600en_US
dc.identifier.scopusauthoridCacicedo, L=7006473174en_US
dc.identifier.scopusauthoridMinamitani, N=6701500352en_US
dc.identifier.scopusauthoridFink, JS=35373029500en_US
dc.identifier.scopusauthoridLechan, RM=7005636129en_US
dc.identifier.scopusauthoridReichlin, S=16186732300en_US
dc.identifier.issnl0013-7227-

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