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Article: Synergism of chronic alcoholism and hepatitis B infection in liver disease

TitleSynergism of chronic alcoholism and hepatitis B infection in liver disease
Authors
Keywordsalcoholic liver disease
hepatitis B infection
synergism.
Issue Date1989
PublisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JGH
Citation
Journal Of Gastroenterology And Hepatology, 1989, v. 4 n. 1, p. 11-16 How to Cite?
AbstractOne hundred and fifty-seven patients with alcoholic liver disease were studied. Hepatitis B surface antigen (HBsAg) was positive in 20.4% of the patients. Those who were positive for the HBsAg presented at an earlier age, had a lower albumin level, a higher globulin level, a more prolonged prothrombin time, were more likely to have features of cirrhosis in the liver biopsy, and were probably more likely to suffer from hepatic encephalopathy in the follow-up compared with those negative for HBsAg. The mortality of subjects was low both on admission and during follow-up. It is concluded that chronic alcoholism and hepatitis B virus infection act synergistically in producing more severe liver damage and causing cirrhosis at a younger age compared with chronic alcoholism alone. One possible reason for the low mortality of the patients might have been their relatively good nutritional status.
Persistent Identifierhttp://hdl.handle.net/10722/161804
ISSN
2023 Impact Factor: 3.7
2023 SCImago Journal Rankings: 1.179
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChung, HTen_US
dc.contributor.authorLai, CLen_US
dc.contributor.authorWu, PCen_US
dc.contributor.authorLok, ASFen_US
dc.date.accessioned2012-09-05T05:15:11Z-
dc.date.available2012-09-05T05:15:11Z-
dc.date.issued1989en_US
dc.identifier.citationJournal Of Gastroenterology And Hepatology, 1989, v. 4 n. 1, p. 11-16en_US
dc.identifier.issn0815-9319en_US
dc.identifier.urihttp://hdl.handle.net/10722/161804-
dc.description.abstractOne hundred and fifty-seven patients with alcoholic liver disease were studied. Hepatitis B surface antigen (HBsAg) was positive in 20.4% of the patients. Those who were positive for the HBsAg presented at an earlier age, had a lower albumin level, a higher globulin level, a more prolonged prothrombin time, were more likely to have features of cirrhosis in the liver biopsy, and were probably more likely to suffer from hepatic encephalopathy in the follow-up compared with those negative for HBsAg. The mortality of subjects was low both on admission and during follow-up. It is concluded that chronic alcoholism and hepatitis B virus infection act synergistically in producing more severe liver damage and causing cirrhosis at a younger age compared with chronic alcoholism alone. One possible reason for the low mortality of the patients might have been their relatively good nutritional status.en_US
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JGHen_US
dc.relation.ispartofJournal of Gastroenterology and Hepatologyen_US
dc.subjectalcoholic liver disease-
dc.subjecthepatitis B infection-
dc.subjectsynergism.-
dc.subject.meshFemaleen_US
dc.subject.meshHepatitis B - Complications - Mortality - Pathologyen_US
dc.subject.meshHepatitis B Surface Antigens - Analysisen_US
dc.subject.meshHong Kong - Epidemiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshLiver - Pathologyen_US
dc.subject.meshLiver Diseases, Alcoholic - Complications - Mortality - Pathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.titleSynergism of chronic alcoholism and hepatitis B infection in liver diseaseen_US
dc.typeArticleen_US
dc.identifier.emailLai, CL:hrmelcl@hku.hken_US
dc.identifier.authorityLai, CL=rp00314en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1440-1746.1989.tb00801.x-
dc.identifier.pmid2490936-
dc.identifier.scopuseid_2-s2.0-0024580926en_US
dc.identifier.volume4en_US
dc.identifier.issue1en_US
dc.identifier.spage11en_US
dc.identifier.epage16en_US
dc.identifier.isiWOS:A1989T784900002-
dc.publisher.placeAustraliaen_US
dc.identifier.scopusauthoridChung, HT=7404007053en_US
dc.identifier.scopusauthoridLai, CL=7403086396en_US
dc.identifier.scopusauthoridWu, PC=7403119323en_US
dc.identifier.scopusauthoridLok, ASF=35379868500en_US
dc.identifier.issnl0815-9319-

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