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Article: Immunoglobulin gene rearrangement in the peripheral blood and bone marrow of patients with lymphomas of the mucosa-associated lymphoid tissues

TitleImmunoglobulin gene rearrangement in the peripheral blood and bone marrow of patients with lymphomas of the mucosa-associated lymphoid tissues
Authors
Liang, RChan, VChan, TKTodd, DHo, F
KeywordsImmunoglobulin gene rearrangement
Malignant lymphoma
Issue Date1990
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/AHA
Citation
Acta Haematologica, 1990, v. 84 n. 1, p. 19-23 How to Cite?
DOI: http://dx.doi.org/10.1159/000205021
AbstractThe theory of 'homing' mechanism has been proposed to explain the association of malignant lymphoma involving multiple sites of mucosa-associated lymphoid tissue (MALT). DNA rearrangement in the peripheral blood and bone marrow specimens of 20 patinets with MALT lymphoma were studied utilizing JH and Cβ gene probes, aiming to detect circulating lymphoma cells and unrecognized bone marrow involvement. Our search for malignant cells in the peripheral blood was unrewarding and the 'homing' theory remained unproven. However, the study of DNA rearrangement showed to be useful in determining the malignant nature of abnormal lymphoid aggregates found in the bone marrow of these patients.
Persistent Identifierhttp://hdl.handle.net/10722/161840
ISSN
0001-5792
2021 Impact Factor: 3.068
2020 SCImago Journal Rankings: 0.574
ISI Accession Number ID
WOS:A1990DU41700004

 

DC FieldValueLanguage
dc.contributor.authorLiang, Ren_US
dc.contributor.authorChan, Ven_US
dc.contributor.authorChan, TKen_US
dc.contributor.authorTodd, Den_US
dc.contributor.authorHo, Fen_US
dc.date.accessioned2012-09-05T05:15:25Z-
dc.date.available2012-09-05T05:15:25Z-
dc.date.issued1990en_US
dc.identifier.citationActa Haematologica, 1990, v. 84 n. 1, p. 19-23en_US
dc.identifier.issn0001-5792en_US
dc.identifier.urihttp://hdl.handle.net/10722/161840-
dc.description.abstractThe theory of 'homing' mechanism has been proposed to explain the association of malignant lymphoma involving multiple sites of mucosa-associated lymphoid tissue (MALT). DNA rearrangement in the peripheral blood and bone marrow specimens of 20 patinets with MALT lymphoma were studied utilizing JH and Cβ gene probes, aiming to detect circulating lymphoma cells and unrecognized bone marrow involvement. Our search for malignant cells in the peripheral blood was unrewarding and the 'homing' theory remained unproven. However, the study of DNA rearrangement showed to be useful in determining the malignant nature of abnormal lymphoid aggregates found in the bone marrow of these patients.en_US
dc.languageengen_US
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/AHAen_US
dc.relation.ispartofActa Haematologicaen_US
dc.subjectImmunoglobulin gene rearrangement-
dc.subjectMalignant lymphoma-
dc.subject.meshAdulten_US
dc.subject.meshBone Marrow - Analysis - Immunologyen_US
dc.subject.meshDna Probesen_US
dc.subject.meshDna, Neoplasm - Analysis - Geneticsen_US
dc.subject.meshGene Rearrangement - Geneticsen_US
dc.subject.meshGenes, Immunoglobulin - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshLymphoid Tissue - Immunologyen_US
dc.subject.meshLymphoma, Non-Hodgkin - Genetics - Immunologyen_US
dc.subject.meshMucous Membrane - Immunologyen_US
dc.titleImmunoglobulin gene rearrangement in the peripheral blood and bone marrow of patients with lymphomas of the mucosa-associated lymphoid tissuesen_US
dc.typeArticleen_US
dc.identifier.emailLiang, R:rliang@hku.hken_US
dc.identifier.emailChan, V:vnychana@hkucc.hku.hken_US
dc.identifier.authorityLiang, R=rp00345en_US
dc.identifier.authorityChan, V=rp00320en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1159/000205021-
dc.identifier.pmid2117323-
dc.identifier.scopuseid_2-s2.0-0025308844en_US
dc.identifier.volume84en_US
dc.identifier.issue1en_US
dc.identifier.spage19en_US
dc.identifier.epage23en_US
dc.identifier.isiWOS:A1990DU41700004-
dc.publisher.placeSwitzerlanden_US
dc.identifier.scopusauthoridLiang, R=26643224900en_US
dc.identifier.scopusauthoridChan, V=7202654865en_US
dc.identifier.scopusauthoridChan, TK=7402687762en_US
dc.identifier.scopusauthoridTodd, D=7201388182en_US
dc.identifier.scopusauthoridHo, F=7103408147en_US
dc.identifier.issnl0001-5792-

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