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Article: Rearrangement of immunoglobulin and T cell receptor genes in acute and chronic leukaemias

TitleRearrangement of immunoglobulin and T cell receptor genes in acute and chronic leukaemias
Authors
Liang, RChan, VChan, TKChiu, ETodd, D
KeywordsImmunoglobulin gene
Leukaemias
T cell receptor gene
Issue Date1991
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/AHA
Citation
Acta Haematologica, 1991, v. 85 n. 2, p. 71-75 How to Cite?
DOI: http://dx.doi.org/10.1159/000204860
AbstractThe pattern of immunoglobulin (Ig) and T cell receptor (TCR) gene rearrangements was determined in 87 patients with acute and chronic leukaemias and myelodysplastic syndromes by Southern blot hybridisation. All 31 cases of common, B cell and null cell acute lymphoblastic leukaemia, and B cell chronic lymphocytic leukaemia showed Ig heavy chain (JH) rearrangement, and TCR (beta-chain) rearrangement was seen in all 5 cases of T cell acute lymphoblastic leukaemia. Inappropriate JH and TCR (beta) rearrangements were present in some cases of T-ALL (60%) and common acute lymphoblastic leukaemia (18%), respectively. For the 19 patients with acute leukaemias following chronic myeloid leukaemia, blastic transformation, all 4 with lymphoid transformation and 3 of the 15 with myeloid transformation had JH rearrangement, and 3 CD10-positive lymphoid transformation and 2 myeloid transformation had their TCR (beta) genes rearranged. In conclusion, the pattern of Ig and TCR gene rearrangements correlated well with the cell lineage. However, cross-lineage rearrangements were more commonly seen in patients with acute leukaemias following chronic myeloid leukaemia blastic transformation, as compared to the de novo cases.
Persistent Identifierhttp://hdl.handle.net/10722/161853
ISSN
0001-5792
2023 Impact Factor: 1.7
2023 SCImago Journal Rankings: 0.686
ISI Accession Number ID
WOS:A1991FK75000004

 

DC FieldValueLanguage
dc.contributor.authorLiang, Ren_US
dc.contributor.authorChan, Ven_US
dc.contributor.authorChan, TKen_US
dc.contributor.authorChiu, Een_US
dc.contributor.authorTodd, Den_US
dc.date.accessioned2012-09-05T05:15:31Z-
dc.date.available2012-09-05T05:15:31Z-
dc.date.issued1991en_US
dc.identifier.citationActa Haematologica, 1991, v. 85 n. 2, p. 71-75en_US
dc.identifier.issn0001-5792en_US
dc.identifier.urihttp://hdl.handle.net/10722/161853-
dc.description.abstractThe pattern of immunoglobulin (Ig) and T cell receptor (TCR) gene rearrangements was determined in 87 patients with acute and chronic leukaemias and myelodysplastic syndromes by Southern blot hybridisation. All 31 cases of common, B cell and null cell acute lymphoblastic leukaemia, and B cell chronic lymphocytic leukaemia showed Ig heavy chain (JH) rearrangement, and TCR (beta-chain) rearrangement was seen in all 5 cases of T cell acute lymphoblastic leukaemia. Inappropriate JH and TCR (beta) rearrangements were present in some cases of T-ALL (60%) and common acute lymphoblastic leukaemia (18%), respectively. For the 19 patients with acute leukaemias following chronic myeloid leukaemia, blastic transformation, all 4 with lymphoid transformation and 3 of the 15 with myeloid transformation had JH rearrangement, and 3 CD10-positive lymphoid transformation and 2 myeloid transformation had their TCR (beta) genes rearranged. In conclusion, the pattern of Ig and TCR gene rearrangements correlated well with the cell lineage. However, cross-lineage rearrangements were more commonly seen in patients with acute leukaemias following chronic myeloid leukaemia blastic transformation, as compared to the de novo cases.en_US
dc.languageengen_US
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/AHAen_US
dc.relation.ispartofActa Haematologicaen_US
dc.subjectImmunoglobulin gene-
dc.subjectLeukaemias-
dc.subjectT cell receptor gene-
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshBlast Crisisen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Rearrangementen_US
dc.subject.meshGene Rearrangement, T-Lymphocyteen_US
dc.subject.meshGene Rearrangement, Beta-Chain T-Cell Antigen Receptoren_US
dc.subject.meshGenes, Immunoglobulinen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunoglobulin Heavy Chains - Geneticsen_US
dc.subject.meshLeukemia - Genetics - Immunologyen_US
dc.subject.meshLeukemia, Lymphocytic, Chronic, B-Cell - Genetics - Immunologyen_US
dc.subject.meshLeukemia, Myelogenous, Chronic, Bcr-Abl Positive - Genetics - Immunology - Pathologyen_US
dc.subject.meshLeukemia, Myeloid, Acute - Genetics - Immunologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMyelodysplastic Syndromes - Genetics - Immunologyen_US
dc.subject.meshPrecursor Cell Lymphoblastic Leukemia-Lymphoma - Genetics - Immunologyen_US
dc.titleRearrangement of immunoglobulin and T cell receptor genes in acute and chronic leukaemiasen_US
dc.typeArticleen_US
dc.identifier.emailLiang, R:rliang@hku.hken_US
dc.identifier.emailChan, V:vnychana@hkucc.hku.hken_US
dc.identifier.authorityLiang, R=rp00345en_US
dc.identifier.authorityChan, V=rp00320en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1159/000204860-
dc.identifier.pmid1850943-
dc.identifier.scopuseid_2-s2.0-0025727392en_US
dc.identifier.volume85en_US
dc.identifier.issue2en_US
dc.identifier.spage71en_US
dc.identifier.epage75en_US
dc.identifier.isiWOS:A1991FK75000004-
dc.publisher.placeSwitzerlanden_US
dc.identifier.scopusauthoridLiang, R=26643224900en_US
dc.identifier.scopusauthoridChan, V=7202654865en_US
dc.identifier.scopusauthoridChan, TK=7402687762en_US
dc.identifier.scopusauthoridChiu, E=24827833600en_US
dc.identifier.scopusauthoridTodd, D=7201388182en_US
dc.identifier.issnl0001-5792-

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