File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1016/S0140-6736(94)91644-6
- Scopus: eid_2-s2.0-0028074591
- PMID: 7934433
- WOS: WOS:A1994PK97800012
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Ultrasound measurement of placental thickness to detect pregnancies affected by homozygous α-thalassaemia-1
Title | Ultrasound measurement of placental thickness to detect pregnancies affected by homozygous α-thalassaemia-1 |
---|---|
Authors | |
Issue Date | 1994 |
Publisher | The Lancet Publishing Group. The Journal's web site is located at http://www.elsevier.com/locate/lancet |
Citation | Lancet, 1994, v. 344 n. 8928, p. 988-989 How to Cite? |
Abstract | Homozygous α-thalassaemia-1, a common cause of hydrops fetalis, is usually diagnosed invasively. We measured placental thickness by ultrasound at 10-21 weeks' gestation in 231 at-risk pregnancies. 60 were affected (by DNA analysis). The sensitivity and specificity in detecting affected pregnancies at cut-off of mean placental thickness plus 2 SD before 12 weeks' gestation were 0.72 (95% CI 0.52-0.93) and 0.97 (0.9-1.0). After 12 weeks sensitivity increased to 0.95 (0.89-1.0) and by 18 weeks reached 1.0 (0.60-0.99) without change in specificity. Selection of pregnancies at risk by measurement of placental thickness will reduce the number of invasive diagnostic procedures. |
Persistent Identifier | http://hdl.handle.net/10722/162033 |
ISSN | 2023 Impact Factor: 98.4 2023 SCImago Journal Rankings: 12.113 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ghosh, A | en_HK |
dc.contributor.author | Tang, MHY | en_HK |
dc.contributor.author | Lam, YH | en_HK |
dc.contributor.author | Fung, E | en_HK |
dc.contributor.author | Chan, V | en_HK |
dc.date.accessioned | 2012-09-05T05:16:47Z | - |
dc.date.available | 2012-09-05T05:16:47Z | - |
dc.date.issued | 1994 | en_HK |
dc.identifier.citation | Lancet, 1994, v. 344 n. 8928, p. 988-989 | en_HK |
dc.identifier.issn | 0140-6736 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/162033 | - |
dc.description.abstract | Homozygous α-thalassaemia-1, a common cause of hydrops fetalis, is usually diagnosed invasively. We measured placental thickness by ultrasound at 10-21 weeks' gestation in 231 at-risk pregnancies. 60 were affected (by DNA analysis). The sensitivity and specificity in detecting affected pregnancies at cut-off of mean placental thickness plus 2 SD before 12 weeks' gestation were 0.72 (95% CI 0.52-0.93) and 0.97 (0.9-1.0). After 12 weeks sensitivity increased to 0.95 (0.89-1.0) and by 18 weeks reached 1.0 (0.60-0.99) without change in specificity. Selection of pregnancies at risk by measurement of placental thickness will reduce the number of invasive diagnostic procedures. | en_HK |
dc.language | eng | en_US |
dc.publisher | The Lancet Publishing Group. The Journal's web site is located at http://www.elsevier.com/locate/lancet | en_HK |
dc.relation.ispartof | Lancet | en_HK |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Fetal Diseases - Ultrasonography | en_US |
dc.subject.mesh | Homozygote | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Infant, Newborn | en_US |
dc.subject.mesh | Placenta - Ultrasonography | en_US |
dc.subject.mesh | Pregnancy | en_US |
dc.subject.mesh | Sensitivity And Specificity | en_US |
dc.subject.mesh | Ultrasonography, Prenatal | en_US |
dc.subject.mesh | Alpha-Thalassemia - Genetics - Ultrasonography | en_US |
dc.title | Ultrasound measurement of placental thickness to detect pregnancies affected by homozygous α-thalassaemia-1 | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Tang, MHY: mhytang@hkucc.hku.hk | en_HK |
dc.identifier.email | Chan, V: vnychana@hkucc.hku.hk | en_HK |
dc.identifier.authority | Tang, MHY=rp01701 | en_HK |
dc.identifier.authority | Chan, V=rp00320 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/S0140-6736(94)91644-6 | en_HK |
dc.identifier.pmid | 7934433 | - |
dc.identifier.scopus | eid_2-s2.0-0028074591 | en_HK |
dc.identifier.hkuros | 4694 | - |
dc.identifier.volume | 344 | en_HK |
dc.identifier.issue | 8928 | en_HK |
dc.identifier.spage | 988 | en_HK |
dc.identifier.epage | 989 | en_HK |
dc.identifier.isi | WOS:A1994PK97800012 | - |
dc.publisher.place | United Kingdom | en_HK |
dc.identifier.scopusauthorid | Ghosh, A=7403963873 | en_HK |
dc.identifier.scopusauthorid | Tang, MHY=35362943900 | en_HK |
dc.identifier.scopusauthorid | Lam, YH=7202563903 | en_HK |
dc.identifier.scopusauthorid | Fung, E=35880889500 | en_HK |
dc.identifier.scopusauthorid | Chan, V=7202654865 | en_HK |
dc.identifier.issnl | 0140-6736 | - |