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Article: An (A-C)(n) dinucleotide repeat polymorphic marker at the 5' end of the aldose reductase gene is associated with early-onset diabetic retinopathy in NIDDM patients

TitleAn (A-C)(n) dinucleotide repeat polymorphic marker at the 5' end of the aldose reductase gene is associated with early-onset diabetic retinopathy in NIDDM patients
Authors
Ko, BCBLam, KSLWat, NMSChung, SSM
Issue Date1995
PublisherAmerican Diabetes Association. The Journal's web site is located at http://diabetes.diabetesjournals.org/
Citation
Diabetes, 1995, v. 44 n. 7, p. 727-732 How to Cite?
DOI: http://dx.doi.org/10.2337/diabetes.44.7.727
AbstractTo study the relationship between the aldose reductase gene and diabetic complications, an (A-C)(n) dinucleotide repeat sequence 2.1 kb upstream of the transcription start site of this gene was identified and studied. There are seven alleles at this locus with a polymorphism information content of 0.73 and a heterozygosity of 0.77 among the Chinese population in Hong Kong. One of the alleles (Z-2) was found to be associated with early onset of retinopathy in patients with non-insulin-dependent diabetes (P = 0.007), suggesting that aldose reductase or a gene in the close vicinity may be involved in the pathogenesis of this diabetic complication.
Persistent Identifierhttp://hdl.handle.net/10722/162099
ISSN
0012-1797
2023 Impact Factor: 6.2
2023 SCImago Journal Rankings: 2.541
ISI Accession Number ID
WOS:A1995RP49300002

 

DC FieldValueLanguage
dc.contributor.authorKo, BCBen_HK
dc.contributor.authorLam, KSLen_HK
dc.contributor.authorWat, NMSen_HK
dc.contributor.authorChung, SSMen_HK
dc.date.accessioned2012-09-05T05:17:20Z-
dc.date.available2012-09-05T05:17:20Z-
dc.date.issued1995en_HK
dc.identifier.citationDiabetes, 1995, v. 44 n. 7, p. 727-732en_HK
dc.identifier.issn0012-1797en_HK
dc.identifier.urihttp://hdl.handle.net/10722/162099-
dc.description.abstractTo study the relationship between the aldose reductase gene and diabetic complications, an (A-C)(n) dinucleotide repeat sequence 2.1 kb upstream of the transcription start site of this gene was identified and studied. There are seven alleles at this locus with a polymorphism information content of 0.73 and a heterozygosity of 0.77 among the Chinese population in Hong Kong. One of the alleles (Z-2) was found to be associated with early onset of retinopathy in patients with non-insulin-dependent diabetes (P = 0.007), suggesting that aldose reductase or a gene in the close vicinity may be involved in the pathogenesis of this diabetic complication.en_HK
dc.languageengen_US
dc.publisherAmerican Diabetes Association. The Journal's web site is located at http://diabetes.diabetesjournals.org/en_HK
dc.relation.ispartofDiabetesen_HK
dc.subject.meshAdulten_US
dc.subject.meshAge Of Onseten_US
dc.subject.meshAldehyde Reductase - Geneticsen_US
dc.subject.meshBase Sequenceen_US
dc.subject.meshChina - Ethnologyen_US
dc.subject.meshCloning, Molecularen_US
dc.subject.meshDna - Geneticsen_US
dc.subject.meshDna Primersen_US
dc.subject.meshDna, Satellite - Geneticsen_US
dc.subject.meshDiabetes Mellitus - Enzymology - Geneticsen_US
dc.subject.meshDiabetes Mellitus, Type 2 - Enzymology - Geneticsen_US
dc.subject.meshDiabetic Retinopathy - Enzymology - Epidemiology - Geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHeterozygote Detectionen_US
dc.subject.meshHong Kongen_US
dc.subject.meshHumansen_US
dc.subject.meshIntronsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshPolymerase Chain Reaction - Methodsen_US
dc.subject.meshPolymorphism, Geneticen_US
dc.subject.meshReference Valuesen_US
dc.subject.meshRepetitive Sequences, Nucleic Aciden_US
dc.subject.meshRisk Factorsen_US
dc.titleAn (A-C)(n) dinucleotide repeat polymorphic marker at the 5' end of the aldose reductase gene is associated with early-onset diabetic retinopathy in NIDDM patientsen_HK
dc.typeArticleen_HK
dc.identifier.emailLam, KSL: ksllam@hku.hken_HK
dc.identifier.emailChung, SSM: smchung@hkucc.hku.hken_HK
dc.identifier.authorityLam, KSL=rp00343en_HK
dc.identifier.authorityChung, SSM=rp00376en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.2337/diabetes.44.7.727-
dc.identifier.pmid7789640-
dc.identifier.scopuseid_2-s2.0-0029112492en_HK
dc.identifier.hkuros13604-
dc.identifier.hkuros9880-
dc.identifier.volume44en_HK
dc.identifier.issue7en_HK
dc.identifier.spage727en_HK
dc.identifier.epage732en_HK
dc.identifier.isiWOS:A1995RP49300002-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridKo, BCB=7102833927en_HK
dc.identifier.scopusauthoridLam, KSL=8082870600en_HK
dc.identifier.scopusauthoridWat, NMS=6602131754en_HK
dc.identifier.scopusauthoridChung, SSM=14120761600en_HK
dc.identifier.issnl0012-1797-

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