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Article: A reverse dot-blot method for rapid detection of non-deletion α thalassaemia

TitleA reverse dot-blot method for rapid detection of non-deletion α thalassaemia
Authors
Chan, VYam, IChen, FEChan, TK
KeywordsAllele-specific hybridization
Non-deletion α thalassaemia
Reverse dot blot
Issue Date1999
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJH
Citation
British Journal Of Haematology, 1999, v. 104 n. 3, p. 513-515 How to Cite?
DOI: http://dx.doi.org/10.1046/j.1365-2141.1999.01221.x
AbstractA reverse dot blot method based on membrane-bound allele-specific oligonucleotides as hybridization targets for amplified α-gene fragments has been developed for the rapid detection of four non-deletion α thalassaemia defects found in the Chinese. Since these non-deletion defects account for 22.8% of haemoglobin H disease, a sensitive, specific and rapid screening method should be of value.
Persistent Identifierhttp://hdl.handle.net/10722/162337
ISSN
0007-1048
2021 Impact Factor: 8.615
2020 SCImago Journal Rankings: 1.907
ISI Accession Number ID
WOS:000079137300016
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorChan, Ven_US
dc.contributor.authorYam, Ien_US
dc.contributor.authorChen, FEen_US
dc.contributor.authorChan, TKen_US
dc.date.accessioned2012-09-05T05:19:06Z-
dc.date.available2012-09-05T05:19:06Z-
dc.date.issued1999en_US
dc.identifier.citationBritish Journal Of Haematology, 1999, v. 104 n. 3, p. 513-515en_US
dc.identifier.issn0007-1048en_US
dc.identifier.urihttp://hdl.handle.net/10722/162337-
dc.description.abstractA reverse dot blot method based on membrane-bound allele-specific oligonucleotides as hybridization targets for amplified α-gene fragments has been developed for the rapid detection of four non-deletion α thalassaemia defects found in the Chinese. Since these non-deletion defects account for 22.8% of haemoglobin H disease, a sensitive, specific and rapid screening method should be of value.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJHen_US
dc.relation.ispartofBritish Journal of Haematologyen_US
dc.rightsBritish Journal of Haematology. Copyright © Blackwell Publishing Ltd.-
dc.subjectAllele-specific hybridization-
dc.subjectNon-deletion α thalassaemia-
dc.subjectReverse dot blot-
dc.subject.meshHumansen_US
dc.subject.meshNucleic Acid Hybridization - Methodsen_US
dc.subject.meshPolymerase Chain Reaction - Methodsen_US
dc.subject.meshSensitivity And Specificityen_US
dc.subject.meshAlpha-Thalassemia - Diagnosisen_US
dc.titleA reverse dot-blot method for rapid detection of non-deletion α thalassaemiaen_US
dc.typeArticleen_US
dc.identifier.emailChan, V:vnychana@hkucc.hku.hken_US
dc.identifier.authorityChan, V=rp00320en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1046/j.1365-2141.1999.01221.x-
dc.identifier.pmid10086788-
dc.identifier.scopuseid_2-s2.0-0033025838en_US
dc.identifier.hkuros44836-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033025838&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume104en_US
dc.identifier.issue3en_US
dc.identifier.spage513en_US
dc.identifier.epage515en_US
dc.identifier.isiWOS:000079137300016-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridChan, V=7202654865en_US
dc.identifier.scopusauthoridYam, I=6603358817en_US
dc.identifier.scopusauthoridChen, FE=17934080100en_US
dc.identifier.scopusauthoridChan, TK=7402687762en_US
dc.identifier.issnl0007-1048-

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