File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Respiratory ciliary function in bone marrow recipients

TitleRespiratory ciliary function in bone marrow recipients
Authors
KeywordsBone marrow transplantation
Bronchiolitis obliterans
Ciliary function
Graft-versus-host disease
Issue Date2001
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bmt
Citation
Bone Marrow Transplantation, 2001, v. 27 n. 11, p. 1147-1151 How to Cite?
AbstractBone marrow transplantation (BMT) recipients, particularly those with chronic graft-versus-host disease (GVHD), suffer from respiratory tract problems, including bronchiolitis obliterans (BO) and recurrent lower respiratory tract infections. Minute cilia beat continuously on the surface of respiratory mucosa, and this beating maintains the sterility of the lower respiratory tract. Dysfunction of respiratory cilia could lead to development of recurrent respiratory tract infections, which are also features of BMT recipients, although ciliary function has not been systematically studied among these subjects. We have, therefore, investigated the ciliary beat frequency (CBF) of 36 Chinese patients who had undergone allogeneic BMT. The CBF was significantly lower in the BMT group compared to controls (P < 0.001). The reduction in CBF was more severe in patients with cGVHD and BO compared with their counterparts (P = 0.048 and P = 0.077, respectively). There was a correlation between CBF with forced expiratory flow rate FEF (P = 0.024) and forced expiratory volume FEV (P = 0.044). We conclude that abnormal ciliary clearance is a common feature after allogeneic BMT, particularly among patients with BO and cGVHD. Further studies are indicated to evaluate this important phenomenon, which could be an important cause of the susceptibility for BMT recipients to respiratory infections.
Persistent Identifierhttp://hdl.handle.net/10722/162486
ISSN
2023 Impact Factor: 4.5
2023 SCImago Journal Rankings: 1.318
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorAu, WYen_US
dc.contributor.authorHo, JCen_US
dc.contributor.authorLie, AKen_US
dc.contributor.authorSun, Jen_US
dc.contributor.authorZheng, Len_US
dc.contributor.authorLiang, Ren_US
dc.contributor.authorLam, WKen_US
dc.contributor.authorTsang, KWen_US
dc.date.accessioned2012-09-05T05:20:28Z-
dc.date.available2012-09-05T05:20:28Z-
dc.date.issued2001en_US
dc.identifier.citationBone Marrow Transplantation, 2001, v. 27 n. 11, p. 1147-1151en_US
dc.identifier.issn0268-3369en_US
dc.identifier.urihttp://hdl.handle.net/10722/162486-
dc.description.abstractBone marrow transplantation (BMT) recipients, particularly those with chronic graft-versus-host disease (GVHD), suffer from respiratory tract problems, including bronchiolitis obliterans (BO) and recurrent lower respiratory tract infections. Minute cilia beat continuously on the surface of respiratory mucosa, and this beating maintains the sterility of the lower respiratory tract. Dysfunction of respiratory cilia could lead to development of recurrent respiratory tract infections, which are also features of BMT recipients, although ciliary function has not been systematically studied among these subjects. We have, therefore, investigated the ciliary beat frequency (CBF) of 36 Chinese patients who had undergone allogeneic BMT. The CBF was significantly lower in the BMT group compared to controls (P < 0.001). The reduction in CBF was more severe in patients with cGVHD and BO compared with their counterparts (P = 0.048 and P = 0.077, respectively). There was a correlation between CBF with forced expiratory flow rate FEF (P = 0.024) and forced expiratory volume FEV (P = 0.044). We conclude that abnormal ciliary clearance is a common feature after allogeneic BMT, particularly among patients with BO and cGVHD. Further studies are indicated to evaluate this important phenomenon, which could be an important cause of the susceptibility for BMT recipients to respiratory infections.en_US
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bmten_US
dc.relation.ispartofBone Marrow Transplantationen_US
dc.subjectBone marrow transplantation-
dc.subjectBronchiolitis obliterans-
dc.subjectCiliary function-
dc.subjectGraft-versus-host disease-
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshBone Marrow Transplantation - Adverse Effectsen_US
dc.subject.meshBronchiolitis Obliterans - Etiologyen_US
dc.subject.meshCiliary Motility Disorders - Complications - Etiologyen_US
dc.subject.meshCohort Studiesen_US
dc.subject.meshFemaleen_US
dc.subject.meshHematologic Neoplasms - Complications - Therapyen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshRespiratory Function Testsen_US
dc.subject.meshRespiratory Mucosa - Pathologyen_US
dc.subject.meshTransplantation Conditioning - Methodsen_US
dc.subject.meshTransplantation, Homologous - Adverse Effectsen_US
dc.titleRespiratory ciliary function in bone marrow recipientsen_US
dc.typeArticleen_US
dc.identifier.emailHo, JC:jhocm@hku.hken_US
dc.identifier.emailLiang, R:rliang@hku.hken_US
dc.identifier.authorityHo, JC=rp00258en_US
dc.identifier.authorityLiang, R=rp00345en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1038/sj.bmt.1703049en_US
dc.identifier.pmid11551025-
dc.identifier.scopuseid_2-s2.0-0034960105en_US
dc.identifier.hkuros59926-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034960105&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume27en_US
dc.identifier.issue11en_US
dc.identifier.spage1147en_US
dc.identifier.epage1151en_US
dc.identifier.isiWOS:000169514800006-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridAu, WY=7202383089en_US
dc.identifier.scopusauthoridHo, JC=7402649981en_US
dc.identifier.scopusauthoridLie, AK=24284842400en_US
dc.identifier.scopusauthoridSun, J=7410371598en_US
dc.identifier.scopusauthoridZheng, L=7403404086en_US
dc.identifier.scopusauthoridLiang, R=26643224900en_US
dc.identifier.scopusauthoridLam, WK=7203021937en_US
dc.identifier.scopusauthoridTsang, KW=7201555024en_US
dc.identifier.issnl0268-3369-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats