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Article: Induction of unspliced c-fos messenger RNA in rodent brain by kainic acid and lipopolysaccharide

TitleInduction of unspliced c-fos messenger RNA in rodent brain by kainic acid and lipopolysaccharide
Authors
KeywordsGene regulation
Kainic acid
Phosphorylation
Primary cell culture
Seizure
Transcription factors
Issue Date2001
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neulet
Citation
Neuroscience Letters, 2001, v. 305 n. 1, p. 17-20 How to Cite?
AbstractThe c-fos transcriptional factor forms an activator protein-1 (AP-1) complex with proteins from the Jun family, which plays an important role in the central nervous system. The responses of AP-1 transcriptional factors induced by kainic acid (KA) treatment have been well studied, although the transcriptional regulation of these KA-induced factors has not been clearly characterized. To investigate the role of different stimuli in controlling of the splicing of c-fos mRNA, we performed reverse transcriptional polymerase chain reaction. The results showed that spliced and unspliced c-fos is present in rat brain following KA treatment and in lipopolysaccharide (LPS)-treated primary mouse cortical brain cell cultures. Furthermore, tyrosine kinase and protein phosphatase inhibitors alter the preponderance of c-fos transcripts following LPS treatment. © 2001 Elsevier Science Ireland Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/162528
ISSN
2023 Impact Factor: 2.5
2023 SCImago Journal Rankings: 0.745
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorFeng, Zen_US
dc.contributor.authorKong, LYen_US
dc.contributor.authorQi, Qen_US
dc.contributor.authorHo, SLen_US
dc.contributor.authorTiao, Nen_US
dc.contributor.authorBing, Gen_US
dc.contributor.authorHan, YFen_US
dc.date.accessioned2012-09-05T05:20:48Z-
dc.date.available2012-09-05T05:20:48Z-
dc.date.issued2001en_US
dc.identifier.citationNeuroscience Letters, 2001, v. 305 n. 1, p. 17-20en_US
dc.identifier.issn0304-3940en_US
dc.identifier.urihttp://hdl.handle.net/10722/162528-
dc.description.abstractThe c-fos transcriptional factor forms an activator protein-1 (AP-1) complex with proteins from the Jun family, which plays an important role in the central nervous system. The responses of AP-1 transcriptional factors induced by kainic acid (KA) treatment have been well studied, although the transcriptional regulation of these KA-induced factors has not been clearly characterized. To investigate the role of different stimuli in controlling of the splicing of c-fos mRNA, we performed reverse transcriptional polymerase chain reaction. The results showed that spliced and unspliced c-fos is present in rat brain following KA treatment and in lipopolysaccharide (LPS)-treated primary mouse cortical brain cell cultures. Furthermore, tyrosine kinase and protein phosphatase inhibitors alter the preponderance of c-fos transcripts following LPS treatment. © 2001 Elsevier Science Ireland Ltd.en_US
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neuleten_US
dc.relation.ispartofNeuroscience Lettersen_US
dc.subjectGene regulation-
dc.subjectKainic acid-
dc.subjectPhosphorylation-
dc.subjectPrimary cell culture-
dc.subjectSeizure-
dc.subjectTranscription factors-
dc.subject.meshAnimalsen_US
dc.subject.meshBase Sequence - Geneticsen_US
dc.subject.meshBrain - Drug Effects - Metabolismen_US
dc.subject.meshDna, Recombinanten_US
dc.subject.meshExcitatory Amino Acid Agonists - Pharmacologyen_US
dc.subject.meshKainic Acid - Pharmacologyen_US
dc.subject.meshLipopolysaccharides - Pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshProto-Oncogene Proteins C-Fos - Geneticsen_US
dc.subject.meshRna, Messenger - Metabolismen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred F344en_US
dc.subject.meshReverse Transcriptase Polymerase Chain Reactionen_US
dc.titleInduction of unspliced c-fos messenger RNA in rodent brain by kainic acid and lipopolysaccharideen_US
dc.typeArticleen_US
dc.identifier.emailHo, SL:slho@hku.hken_US
dc.identifier.authorityHo, SL=rp00240en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0304-3940(01)01793-1en_US
dc.identifier.pmid11356297-
dc.identifier.scopuseid_2-s2.0-0035371488en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035371488&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume305en_US
dc.identifier.issue1en_US
dc.identifier.spage17en_US
dc.identifier.epage20en_US
dc.identifier.isiWOS:000169118000005-
dc.publisher.placeIrelanden_US
dc.identifier.scopusauthoridFeng, Z=7403442974en_US
dc.identifier.scopusauthoridKong, LY=25934641600en_US
dc.identifier.scopusauthoridQi, Q=35819637700en_US
dc.identifier.scopusauthoridHo, SL=25959633500en_US
dc.identifier.scopusauthoridTiao, N=7801575007en_US
dc.identifier.scopusauthoridBing, G=7004276368en_US
dc.identifier.scopusauthoridHan, YF=37036722900en_US
dc.identifier.issnl0304-3940-

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