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Article: Distinct changes in serum fibroblast growth factor 21 levels in different subtypes of diabetes
Title | Distinct changes in serum fibroblast growth factor 21 levels in different subtypes of diabetes |
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Authors | |
Issue Date | 2012 |
Publisher | The Endocrine Society. The Journal's web site is located at http://jcem.endojournals.org |
Citation | Journal of Clinical Endocrinology and Metabolism, 2012, v. 97 n. 1, p. E54-E58 How to Cite? |
Abstract | Aims: Fibroblast growth factor (FGF) 21 is an endocrine factor with multiple beneficial effects on glucose and lipid metabolism in animals. This study aimed to investigate the association of serum FGF21 levels with type 1 diabetes, latent autoimmune diabetes in adults (LADA) and type 2 diabetes. Methods: Serum FGF21 levels were determined by ELISA in patients with type 1 diabetes (n = 76), LADA (n = 68), type 2 diabetes (n = 77), and their age- and sex-matched controls. The association of serum FGF21 with markers of autoimmunity was studied. Results: In type 1 diabetic patients, serum FGF21 levels were significantly lower than controls [108.3 (61.5-180.1) vs. 196.0 (103.7-330.9) pg/ml, P < 0.001]. In LADA patients, serum FGF21 levels were significantly lower than controls after adjustment for body mass index [210.9 (121.4-441.6) vs. 268.3 (159.5-443.6) pg/ml, P = 0.003]. By contrast, serum FGF21 levels in type 2 diabetic patients were significantly higher than controls [381.2 (244.7-531.3) vs. 301.4 (173.9-444.2) pg/ml, P = 0.006]. FGF21 levels increased progressively from type 1 diabetes, LADA, to type 2 diabetes (P < 0.001 for global trend). Furthermore, FGF21 levels correlated inversely with titers of glutamic acid decarboxylase and insulinoma-associated protein 2 autoantibodies in type 1 diabetic and LADA patients. Conclusions: Serum FGF21 level is increased in type 2 diabetes but decreased in type 1 diabetes and LADA. In autoimmune diabetes, the reduction in circulating FGF21 is closely associated with markers of pancreatic β-cell autoimmunity. Copyright © 2012 by The Endocrine Society. |
Persistent Identifier | http://hdl.handle.net/10722/163504 |
ISSN | 2023 Impact Factor: 5.0 2023 SCImago Journal Rankings: 1.899 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Xiao, Y | en_US |
dc.contributor.author | Xu, A | en_US |
dc.contributor.author | Law, LSC | en_US |
dc.contributor.author | Chen, C | en_US |
dc.contributor.author | Li, H | en_US |
dc.contributor.author | Li, X | en_US |
dc.contributor.author | Yang, L | en_US |
dc.contributor.author | Liu, S | en_US |
dc.contributor.author | Zhou, Z | en_US |
dc.contributor.author | Lam, KSL | en_US |
dc.date.accessioned | 2012-09-05T05:32:39Z | - |
dc.date.available | 2012-09-05T05:32:39Z | - |
dc.date.issued | 2012 | en_US |
dc.identifier.citation | Journal of Clinical Endocrinology and Metabolism, 2012, v. 97 n. 1, p. E54-E58 | en_US |
dc.identifier.issn | 0021-972X | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/163504 | - |
dc.description.abstract | Aims: Fibroblast growth factor (FGF) 21 is an endocrine factor with multiple beneficial effects on glucose and lipid metabolism in animals. This study aimed to investigate the association of serum FGF21 levels with type 1 diabetes, latent autoimmune diabetes in adults (LADA) and type 2 diabetes. Methods: Serum FGF21 levels were determined by ELISA in patients with type 1 diabetes (n = 76), LADA (n = 68), type 2 diabetes (n = 77), and their age- and sex-matched controls. The association of serum FGF21 with markers of autoimmunity was studied. Results: In type 1 diabetic patients, serum FGF21 levels were significantly lower than controls [108.3 (61.5-180.1) vs. 196.0 (103.7-330.9) pg/ml, P < 0.001]. In LADA patients, serum FGF21 levels were significantly lower than controls after adjustment for body mass index [210.9 (121.4-441.6) vs. 268.3 (159.5-443.6) pg/ml, P = 0.003]. By contrast, serum FGF21 levels in type 2 diabetic patients were significantly higher than controls [381.2 (244.7-531.3) vs. 301.4 (173.9-444.2) pg/ml, P = 0.006]. FGF21 levels increased progressively from type 1 diabetes, LADA, to type 2 diabetes (P < 0.001 for global trend). Furthermore, FGF21 levels correlated inversely with titers of glutamic acid decarboxylase and insulinoma-associated protein 2 autoantibodies in type 1 diabetic and LADA patients. Conclusions: Serum FGF21 level is increased in type 2 diabetes but decreased in type 1 diabetes and LADA. In autoimmune diabetes, the reduction in circulating FGF21 is closely associated with markers of pancreatic β-cell autoimmunity. Copyright © 2012 by The Endocrine Society. | en_US |
dc.language | eng | en_US |
dc.publisher | The Endocrine Society. The Journal's web site is located at http://jcem.endojournals.org | en_US |
dc.relation.ispartof | Journal of Clinical Endocrinology and Metabolism | en_US |
dc.subject.mesh | Adolescent | en_US |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Aged | en_US |
dc.subject.mesh | Autoimmunity - Physiology | en_US |
dc.subject.mesh | Blood Glucose - Analysis | en_US |
dc.subject.mesh | Case-Control Studies | en_US |
dc.subject.mesh | Child | en_US |
dc.subject.mesh | Diabetes Mellitus - Blood - Classification | en_US |
dc.subject.mesh | Diabetes Mellitus, Type 1 - Blood | en_US |
dc.subject.mesh | Diabetes Mellitus, Type 2 - Blood | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Fibroblast Growth Factors - Analysis - Blood | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Insulin-Secreting Cells - Immunology | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Middle Aged | en_US |
dc.title | Distinct changes in serum fibroblast growth factor 21 levels in different subtypes of diabetes | en_US |
dc.type | Article | en_US |
dc.identifier.email | Lam, KSL:ksllam@hku.hk | en_US |
dc.identifier.authority | Lam, KSL=rp00343 | en_US |
dc.description.nature | link_to_OA_fulltext | en_US |
dc.identifier.doi | 10.1210/jc.2011-1930 | en_US |
dc.identifier.pmid | 22013098 | - |
dc.identifier.scopus | eid_2-s2.0-84862928486 | en_US |
dc.identifier.hkuros | 204675 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-84862928486&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 97 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.spage | E54 | en_US |
dc.identifier.epage | E58 | en_US |
dc.identifier.isi | WOS:000300393800008 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Xiao, Y=36464707600 | en_US |
dc.identifier.scopusauthorid | Xu, A=55212499600 | en_US |
dc.identifier.scopusauthorid | Law, LSC=55212861700 | en_US |
dc.identifier.scopusauthorid | Chen, C=37025734000 | en_US |
dc.identifier.scopusauthorid | Li, H=54786669500 | en_US |
dc.identifier.scopusauthorid | Li, X=54988955800 | en_US |
dc.identifier.scopusauthorid | Yang, L=9747287700 | en_US |
dc.identifier.scopusauthorid | Liu, S=50361659300 | en_US |
dc.identifier.scopusauthorid | Zhou, Z=8417885800 | en_US |
dc.identifier.scopusauthorid | Lam, KSL=8082870600 | en_US |
dc.customcontrol.immutable | jt 130419 | - |
dc.identifier.issnl | 0021-972X | - |