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- Publisher Website: 10.1002/hep.25718
- Scopus: eid_2-s2.0-84865535075
- PMID: 22422518
- WOS: WOS:000308046700005
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Article: A large case-control study on the predictability of hepatitis B surface antigen levels three years before hepatitis B surface antigen seroclearance
Title | A large case-control study on the predictability of hepatitis B surface antigen levels three years before hepatitis B surface antigen seroclearance |
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Authors | |
Keywords | Antiviral Therapy Hepatitis B Virus Nucleos(T)Ide Analogue |
Issue Date | 2012 |
Publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www.hepatology.org/ |
Citation | Hepatology, 2012, v. 56 n. 3, p. 812-819 How to Cite? |
Abstract | The kinetics of hepatitis B surface antigen (HBsAg) levels preceding spontaneous HBsAg seroclearance has not been fully investigated. The kinetics of HBsAg and hepatitis B virus (HBV) DNA of 203 treatment-naïve, hepatitis B e antigen (HBeAg)-negative patients with spontaneous HBsAg seroclearance were compared with 203 age- and sex-matched HBeAg-negative controls. Serum samples at 3 years, 2 years, 1 year, and 6 months before HBsAg seroclearance and at the time of HBsAg loss were tested. Median HBsAg levels at these respective time points before HBsAg seroclearance were 23.5, 3.51, 0.524, and 0.146 IU/mL. For all time points, patients with HBsAg seroclearance had significantly lower median HBsAg and HBV DNA levels, compared to those of the controls (all P < 0.001). Median HBsAg and HBV DNA levels declined significantly until HBsAg seroclearance (P < 0.001). Although median HBsAg levels also decreased significantly with time (P = 0.006) in controls, median HBV DNA levels remained similar (P = 0.414). Serum HBsAg levels, followed by HBsAg log reduction, were the best predictors of HBsAg seroclearance, with an area under the receiving operator characteristic (AUROC) of 0.833 (95% confidence interval [CI]: 0.792-0.873) and 0.803 (95% CI: 0.755-0.849), respectively. The optimal cut-off HBsAg level and HBsAg reduction to predict HBsAg seroclearance were <200 IU/mL (sensitivity, 84.2%; specificity, 73.4%) and 0.5 log IU/mL/year (sensitivity, 62.8%; specificity, 88.7%), respectively. For patients with HBsAg levels ≥200 IU/mL, an annual 0.5-log reduction was highly predictive of subsequent HBsAg seroclearance (AUROC, 0.867; 95% CI: 0.778-0.956). Conclusion: To conclude, serum HBsAg <200 IU/mL and 0.5-log reduction in HBsAg were predictive of HBsAg seroclearance within 3 years of follow-up. These parameters may serve as good indicators for the consideration of treatment duration and cessation for chronic hepatitis B. © 2012 American Association for the Study of Liver Diseases. |
Persistent Identifier | http://hdl.handle.net/10722/163509 |
ISSN | 2023 Impact Factor: 12.9 2023 SCImago Journal Rankings: 5.011 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Seto, WK | en_HK |
dc.contributor.author | Wong, DKH | en_HK |
dc.contributor.author | Fung, J | en_HK |
dc.contributor.author | Hung, IFN | en_HK |
dc.contributor.author | Fong, DYT | en_HK |
dc.contributor.author | Yuen, JCH | en_HK |
dc.contributor.author | Tong, T | en_HK |
dc.contributor.author | Lai, CL | en_HK |
dc.contributor.author | Yuen, MF | en_HK |
dc.date.accessioned | 2012-09-05T05:32:50Z | - |
dc.date.available | 2012-09-05T05:32:50Z | - |
dc.date.issued | 2012 | en_HK |
dc.identifier.citation | Hepatology, 2012, v. 56 n. 3, p. 812-819 | en_HK |
dc.identifier.issn | 0270-9139 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/163509 | - |
dc.description.abstract | The kinetics of hepatitis B surface antigen (HBsAg) levels preceding spontaneous HBsAg seroclearance has not been fully investigated. The kinetics of HBsAg and hepatitis B virus (HBV) DNA of 203 treatment-naïve, hepatitis B e antigen (HBeAg)-negative patients with spontaneous HBsAg seroclearance were compared with 203 age- and sex-matched HBeAg-negative controls. Serum samples at 3 years, 2 years, 1 year, and 6 months before HBsAg seroclearance and at the time of HBsAg loss were tested. Median HBsAg levels at these respective time points before HBsAg seroclearance were 23.5, 3.51, 0.524, and 0.146 IU/mL. For all time points, patients with HBsAg seroclearance had significantly lower median HBsAg and HBV DNA levels, compared to those of the controls (all P < 0.001). Median HBsAg and HBV DNA levels declined significantly until HBsAg seroclearance (P < 0.001). Although median HBsAg levels also decreased significantly with time (P = 0.006) in controls, median HBV DNA levels remained similar (P = 0.414). Serum HBsAg levels, followed by HBsAg log reduction, were the best predictors of HBsAg seroclearance, with an area under the receiving operator characteristic (AUROC) of 0.833 (95% confidence interval [CI]: 0.792-0.873) and 0.803 (95% CI: 0.755-0.849), respectively. The optimal cut-off HBsAg level and HBsAg reduction to predict HBsAg seroclearance were <200 IU/mL (sensitivity, 84.2%; specificity, 73.4%) and 0.5 log IU/mL/year (sensitivity, 62.8%; specificity, 88.7%), respectively. For patients with HBsAg levels ≥200 IU/mL, an annual 0.5-log reduction was highly predictive of subsequent HBsAg seroclearance (AUROC, 0.867; 95% CI: 0.778-0.956). Conclusion: To conclude, serum HBsAg <200 IU/mL and 0.5-log reduction in HBsAg were predictive of HBsAg seroclearance within 3 years of follow-up. These parameters may serve as good indicators for the consideration of treatment duration and cessation for chronic hepatitis B. © 2012 American Association for the Study of Liver Diseases. | en_HK |
dc.language | eng | en_US |
dc.publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www.hepatology.org/ | en_HK |
dc.relation.ispartof | Hepatology | en_HK |
dc.subject | Antiviral Therapy | en_US |
dc.subject | Hepatitis B Virus | en_US |
dc.subject | Nucleos(T)Ide Analogue | en_US |
dc.title | A large case-control study on the predictability of hepatitis B surface antigen levels three years before hepatitis B surface antigen seroclearance | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Seto, WK: wkseto2@hku.hk | en_HK |
dc.identifier.email | Wong, DKH: danywong@hku.hk | en_HK |
dc.identifier.email | Fung, J: jfung@sicklehut.com | en_HK |
dc.identifier.email | Hung, IFN: ivanhung@hkucc.hku.hk | en_HK |
dc.identifier.email | Fong, DYT: dytfong@hku.hk | en_HK |
dc.identifier.email | Lai, CL: hrmelcl@hku.hk | en_HK |
dc.identifier.email | Yuen, MF: mfyuen@hku.hk | en_HK |
dc.identifier.authority | Seto, WK=rp01659 | en_HK |
dc.identifier.authority | Wong, DKH=rp00492 | en_HK |
dc.identifier.authority | Fung, J=rp00518 | en_HK |
dc.identifier.authority | Hung, IFN=rp00508 | en_HK |
dc.identifier.authority | Fong, DYT=rp00253 | en_HK |
dc.identifier.authority | Lai, CL=rp00314 | en_HK |
dc.identifier.authority | Yuen, MF=rp00479 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1002/hep.25718 | en_HK |
dc.identifier.pmid | 22422518 | - |
dc.identifier.scopus | eid_2-s2.0-84865535075 | en_HK |
dc.identifier.hkuros | 203194 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-84865535075&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 56 | en_HK |
dc.identifier.issue | 3 | en_HK |
dc.identifier.spage | 812 | en_HK |
dc.identifier.epage | 819 | en_HK |
dc.identifier.eissn | 1527-3350 | - |
dc.identifier.isi | WOS:000308046700005 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Seto, WK=23390675900 | en_HK |
dc.identifier.scopusauthorid | Wong, DKH=7401535819 | en_HK |
dc.identifier.scopusauthorid | Fung, J=23091109300 | en_HK |
dc.identifier.scopusauthorid | Hung, IFN=7006103457 | en_HK |
dc.identifier.scopusauthorid | Fong, DYT=35261710300 | en_HK |
dc.identifier.scopusauthorid | Yuen, JCH=7102620480 | en_HK |
dc.identifier.scopusauthorid | Tong, T=55303885400 | en_HK |
dc.identifier.scopusauthorid | Lai, CL=7403086396 | en_HK |
dc.identifier.scopusauthorid | Yuen, MF=7102031955 | en_HK |
dc.identifier.issnl | 0270-9139 | - |