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Article: Pathophysiology of gastroesophageal reflux diseases in Chinese - Role of transient lower esophageal sphincter relaxation and esophageal motor dysfunction

TitlePathophysiology of gastroesophageal reflux diseases in Chinese - Role of transient lower esophageal sphincter relaxation and esophageal motor dysfunction
Authors
Issue Date2004
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ajg/index.html
Citation
American Journal Of Gastroenterology, 2004, v. 99 n. 11, p. 2088-2093 How to Cite?
AbstractBACKGROUND: Transient lower esophageal sphincter relaxation (TLESR) is the major mechanism for AND AIMS: gastroesophageal reflux in the Western population. The major reflux mechanism in Chinese patients with GERD has not been studied before. METHODS: Fifty-four patients with GERD and 28 controls underwent stationary baseline manometry and the 24-h ambulatory esophageal pH monitoring. TLESRs were measured before and after an 850 kcal meal in the supine position. Primary peristalsis, secondary peristalsis, and esophageal acid clearance were measured by esophageal manometry. RESULTS: Total time esophageal pH ≤ 4 (7.3 vs 1.5, p = 0.001) was significantly higher in patients with GERD when compared to controls. Majority of acid reflux episodes was due to TLESR in both patients with GERD and controls. The frequency of TLESRs after meal was similar between patients with GERD and controls (1.0 vs 1.3/h, p = 0.34). There was no difference in the distribution of reflux mechanism between patients with GERD and controls. However, patients with GERD had a significantly lower successful primary peristalsis (59% vs 70%, p = 0.043) when compared to controls. CONCLUSION: The frequency of TLESRs was similar between patients with GERD and controls during stationary manometry. Primary peristalsis was impaired in Chinese patients with GERD. Esophageal motor dysfunction may contribute to the pathophysiology of GERD in the Chinese population.
Persistent Identifierhttp://hdl.handle.net/10722/163518
ISSN
2023 Impact Factor: 8.0
2023 SCImago Journal Rankings: 2.391
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, WMen_US
dc.contributor.authorLai, KCen_US
dc.contributor.authorHui, WMen_US
dc.contributor.authorHu, WHCen_US
dc.contributor.authorHuang, JQen_US
dc.contributor.authorWong, NYHen_US
dc.contributor.authorXia, HHXen_US
dc.contributor.authorChan, OOen_US
dc.contributor.authorLam, SKen_US
dc.contributor.authorWong, BCYen_US
dc.date.accessioned2012-09-05T05:33:00Z-
dc.date.available2012-09-05T05:33:00Z-
dc.date.issued2004en_US
dc.identifier.citationAmerican Journal Of Gastroenterology, 2004, v. 99 n. 11, p. 2088-2093en_US
dc.identifier.issn0002-9270en_US
dc.identifier.urihttp://hdl.handle.net/10722/163518-
dc.description.abstractBACKGROUND: Transient lower esophageal sphincter relaxation (TLESR) is the major mechanism for AND AIMS: gastroesophageal reflux in the Western population. The major reflux mechanism in Chinese patients with GERD has not been studied before. METHODS: Fifty-four patients with GERD and 28 controls underwent stationary baseline manometry and the 24-h ambulatory esophageal pH monitoring. TLESRs were measured before and after an 850 kcal meal in the supine position. Primary peristalsis, secondary peristalsis, and esophageal acid clearance were measured by esophageal manometry. RESULTS: Total time esophageal pH ≤ 4 (7.3 vs 1.5, p = 0.001) was significantly higher in patients with GERD when compared to controls. Majority of acid reflux episodes was due to TLESR in both patients with GERD and controls. The frequency of TLESRs after meal was similar between patients with GERD and controls (1.0 vs 1.3/h, p = 0.34). There was no difference in the distribution of reflux mechanism between patients with GERD and controls. However, patients with GERD had a significantly lower successful primary peristalsis (59% vs 70%, p = 0.043) when compared to controls. CONCLUSION: The frequency of TLESRs was similar between patients with GERD and controls during stationary manometry. Primary peristalsis was impaired in Chinese patients with GERD. Esophageal motor dysfunction may contribute to the pathophysiology of GERD in the Chinese population.en_US
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ajg/index.htmlen_US
dc.relation.ispartofAmerican Journal of Gastroenterologyen_US
dc.subject.meshAsian Continental Ancestry Groupen_US
dc.subject.meshEsophageal Sphincter, Lower - Physiopathologyen_US
dc.subject.meshEsophagitis, Peptic - Ethnology - Physiopathologyen_US
dc.subject.meshEsophagus - Physiopathologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshGastroesophageal Reflux - Ethnology - Physiopathologyen_US
dc.subject.meshHumansen_US
dc.subject.meshHydrogen-Ion Concentrationen_US
dc.subject.meshMaleen_US
dc.subject.meshManometryen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMonitoring, Ambulatoryen_US
dc.subject.meshMuscle Relaxationen_US
dc.subject.meshPeristalsisen_US
dc.titlePathophysiology of gastroesophageal reflux diseases in Chinese - Role of transient lower esophageal sphincter relaxation and esophageal motor dysfunctionen_US
dc.typeArticleen_US
dc.identifier.emailWong, BCY:bcywong@hku.hken_US
dc.identifier.authorityWong, BCY=rp00429en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1572-0241.2004.30417.xen_US
dc.identifier.pmid15554985-
dc.identifier.scopuseid_2-s2.0-8744299479en_US
dc.identifier.hkuros96447-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-8744299479&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume99en_US
dc.identifier.issue11en_US
dc.identifier.spage2088en_US
dc.identifier.epage2093en_US
dc.identifier.isiWOS:000224767900004-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridWong, WM=7403972413en_US
dc.identifier.scopusauthoridLai, KC=7402135595en_US
dc.identifier.scopusauthoridHui, WM=7103196477en_US
dc.identifier.scopusauthoridHu, WHC=7404359791en_US
dc.identifier.scopusauthoridHuang, JQ=7403635051en_US
dc.identifier.scopusauthoridWong, NYH=7202836655en_US
dc.identifier.scopusauthoridXia, HHX=8757161400en_US
dc.identifier.scopusauthoridChan, OO=7403167965en_US
dc.identifier.scopusauthoridLam, SK=7402279473en_US
dc.identifier.scopusauthoridWong, BCY=7402023340en_US
dc.identifier.issnl0002-9270-

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