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- PMID: 23003220
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Article: Prevalence and extent of subclinical atherosclerosis in patients with psoriasis
Title | Prevalence and extent of subclinical atherosclerosis in patients with psoriasis |
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Authors | |
Keywords | Atherosclerosis Psoriasis |
Issue Date | 2013 |
Publisher | Wiley-Blackwell Publishing Ltd.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0954-6820 |
Citation | Journal of Internal Medicine: from genes and molecules to patients, 2013, v. 273 n. 3, p. 273-282 How to Cite? |
Abstract | OBJECTIVE: Patients with psoriasis are prone to premature atherosclerosis and increased risk of cardiovascular disease events. However, the prevalence and extent of atherosclerosis in patients with psoriasis are unknown. DESIGN: A cross-sectional study. SETTING AND SUBJECTS: The prevalence and extent of coronary and carotid atherosclerosis were compared in 70 patients with psoriasis (46 +/- 9 years, 71% male) without known cardiovascular disease or joint involvement and 51 age- and gender-matched healthy control subjects (45 +/- 7 years, 71% male). Systemic inflammation was assessed by the level of high-sensitivity C-reactive protein (hs-CRP). Coronary atherosclerosis was determined by the coronary calcification score (CCS) measured by multi-detector computed tomography. Carotid atherosclerosis was assessed by high-resolution ultrasound-derived carotid intima-media thickness (cIMT). RESULTS: Patients with psoriasis had a higher prevalence of coronary atherosclerosis (CCS > 0; 28.6% vs. 3.9%, P < 0.01), and a higher degree of coronary atherosclerosis estimated by the mean CCS (67.4 +/- 349.2 vs. 0.5 +/- 3.0, P < 0.05) compared with controls. Similarly, cIMT was significantly greater in patients with psoriasis than in control subjects (0.73 +/- 0.11 mm vs. 0.67 +/- 0.08 mm, P < 0.01). Multiple logistic regression revealed that psoriasis [odd ratio (OR): 10.54, 95% confidence interval (CI) 1.89-58.67, P < 0.01] and serum total cholesterol level (OR 2.10, 95% CI 1.01-4.37) were associated with the presence of coronary atherosclerosis (CCS > 0). By contrast, only age was independently associated with increased cIMT. Amongst participants with no traditional cardiovascular disease risk factors, hs-CRP level was higher in patients with psoriasis than in controls. CONCLUSION: The present results demonstrate early-onset, diffuse arterial atherosclerosis in coronary and carotid arteries in patients with psoriasis, but not in age- and gender-matched control subjects. Low-grade inflammation could explain the presence of premature atherosclerosis in patients with psoriasis. |
Persistent Identifier | http://hdl.handle.net/10722/164272 |
ISSN | 2023 Impact Factor: 9.0 2023 SCImago Journal Rankings: 2.895 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Yiu, KH | en_US |
dc.contributor.author | Yeung, CK | en_US |
dc.contributor.author | Zhao, CT | en_US |
dc.contributor.author | Chan, JCY | en_US |
dc.contributor.author | Siu, DCW | en_US |
dc.contributor.author | Tam, S | en_US |
dc.contributor.author | Wong, CS | en_US |
dc.contributor.author | Yan, GH | en_US |
dc.contributor.author | Yue, WS | en_US |
dc.contributor.author | Khong, PL | en_US |
dc.contributor.author | Chan, HH | en_US |
dc.contributor.author | Tse, HF | en_US |
dc.date.accessioned | 2012-09-20T07:57:30Z | - |
dc.date.available | 2012-09-20T07:57:30Z | - |
dc.date.issued | 2013 | en_US |
dc.identifier.citation | Journal of Internal Medicine: from genes and molecules to patients, 2013, v. 273 n. 3, p. 273-282 | en_US |
dc.identifier.issn | 0954-6820 | - |
dc.identifier.uri | http://hdl.handle.net/10722/164272 | - |
dc.description.abstract | OBJECTIVE: Patients with psoriasis are prone to premature atherosclerosis and increased risk of cardiovascular disease events. However, the prevalence and extent of atherosclerosis in patients with psoriasis are unknown. DESIGN: A cross-sectional study. SETTING AND SUBJECTS: The prevalence and extent of coronary and carotid atherosclerosis were compared in 70 patients with psoriasis (46 +/- 9 years, 71% male) without known cardiovascular disease or joint involvement and 51 age- and gender-matched healthy control subjects (45 +/- 7 years, 71% male). Systemic inflammation was assessed by the level of high-sensitivity C-reactive protein (hs-CRP). Coronary atherosclerosis was determined by the coronary calcification score (CCS) measured by multi-detector computed tomography. Carotid atherosclerosis was assessed by high-resolution ultrasound-derived carotid intima-media thickness (cIMT). RESULTS: Patients with psoriasis had a higher prevalence of coronary atherosclerosis (CCS > 0; 28.6% vs. 3.9%, P < 0.01), and a higher degree of coronary atherosclerosis estimated by the mean CCS (67.4 +/- 349.2 vs. 0.5 +/- 3.0, P < 0.05) compared with controls. Similarly, cIMT was significantly greater in patients with psoriasis than in control subjects (0.73 +/- 0.11 mm vs. 0.67 +/- 0.08 mm, P < 0.01). Multiple logistic regression revealed that psoriasis [odd ratio (OR): 10.54, 95% confidence interval (CI) 1.89-58.67, P < 0.01] and serum total cholesterol level (OR 2.10, 95% CI 1.01-4.37) were associated with the presence of coronary atherosclerosis (CCS > 0). By contrast, only age was independently associated with increased cIMT. Amongst participants with no traditional cardiovascular disease risk factors, hs-CRP level was higher in patients with psoriasis than in controls. CONCLUSION: The present results demonstrate early-onset, diffuse arterial atherosclerosis in coronary and carotid arteries in patients with psoriasis, but not in age- and gender-matched control subjects. Low-grade inflammation could explain the presence of premature atherosclerosis in patients with psoriasis. | - |
dc.language | eng | en_US |
dc.publisher | Wiley-Blackwell Publishing Ltd.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0954-6820 | - |
dc.relation.ispartof | Journal of Internal Medicine: from genes and molecules to patients | en_US |
dc.rights | The definitive version is available at www3.interscience.wiley.com | - |
dc.subject | Atherosclerosis | - |
dc.subject | Psoriasis | - |
dc.subject.mesh | Carotid Artery Diseases - epidemiology - ultrasonography | - |
dc.subject.mesh | Coronary Artery Disease - epidemiology - radiography | - |
dc.subject.mesh | Cross-Sectional Studies | - |
dc.subject.mesh | Multidetector Computed Tomography | - |
dc.subject.mesh | Psoriasis - epidemiology | - |
dc.title | Prevalence and extent of subclinical atherosclerosis in patients with psoriasis | en_US |
dc.type | Article | en_US |
dc.identifier.email | Yiu, KH: khkyiu@hku.hk | en_US |
dc.identifier.email | Yeung, CK: drcyeung@hku.hk | en_US |
dc.identifier.email | Siu, DCW: cwdsiu@hkucc.hku.hk | en_US |
dc.identifier.email | Wong, CS: drcswong@hku.hk | en_US |
dc.identifier.email | Yan, GH: guohui@hkucc.hku.hk | - |
dc.identifier.email | Khong, PL: plkhong@hkucc.hku.hk | - |
dc.identifier.email | Tse, HF: hftse@hkucc.hku.hk | - |
dc.identifier.authority | Yiu, KH=rp01490 | en_US |
dc.identifier.authority | Chan, JCY=rp01737 | en_US |
dc.identifier.authority | Siu, DCW=rp00534 | en_US |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1111/joim.12002 | - |
dc.identifier.pmid | 23003220 | - |
dc.identifier.scopus | eid_2-s2.0-84873991348 | - |
dc.identifier.hkuros | 214839 | - |
dc.identifier.hkuros | 237595 | - |
dc.identifier.volume | 273 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 273 | - |
dc.identifier.epage | 282 | - |
dc.identifier.isi | WOS:000315098100007 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 0954-6820 | - |