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Conference Paper: Distinct immunomodulatory effects of human embryonic stem cells (hESC) and hESC-derived cardiomyocytes on human dendritic cells and natural killer cells

TitleDistinct immunomodulatory effects of human embryonic stem cells (hESC) and hESC-derived cardiomyocytes on human dendritic cells and natural killer cells
Authors
Tso, GHWYim, ALYLau, KKLLi, RAChan, CWY
Issue Date2011
Citation
The 2011 Days of Molecular Medicine (DMM) Meeting on Re-engineering Regenerative Medicine, Hong Kong, 10-12 November 2011. How to Cite?
AbstractTransplantation of human embryonic stem cells (hESCs)–derived cardiomyocytes (CM) to damaged heart provides a therapeutic strategy for cardiac tissue regeneration. However, immunologic acceptance of the transplanted CM remains a challenging aspect. Recent findings suggest that iPSC and their derivates are not immunoprivileged and can be rejected upon transplantation. Dendritic cells (DCs) are the major antigen presenting cells to T cells and are key in triggering both the innate and adaptive immune responses. In addition to killing tumor and virus-infected cells, natural killer (NK) cells distinguish allogeneic major histocompatibility complex (MHC) and are participate in transplant rejection. Here we examined the immunomodulatory properties of hESCs and hESCs-derived cardiomyocytes (hESCs-…
DescriptionPoster Session I (no. 12) - Local award winners
Persistent Identifierhttp://hdl.handle.net/10722/165019

 

DC FieldValueLanguage
dc.contributor.authorTso, GHW-
dc.contributor.authorYim, ALY-
dc.contributor.authorLau, KKL-
dc.contributor.authorLi, RA-
dc.contributor.authorChan, CWY-
dc.date.accessioned2012-09-20T08:13:41Z-
dc.date.available2012-09-20T08:13:41Z-
dc.date.issued2011-
dc.identifier.citationThe 2011 Days of Molecular Medicine (DMM) Meeting on Re-engineering Regenerative Medicine, Hong Kong, 10-12 November 2011.-
dc.identifier.urihttp://hdl.handle.net/10722/165019-
dc.descriptionPoster Session I (no. 12) - Local award winners-
dc.description.abstractTransplantation of human embryonic stem cells (hESCs)–derived cardiomyocytes (CM) to damaged heart provides a therapeutic strategy for cardiac tissue regeneration. However, immunologic acceptance of the transplanted CM remains a challenging aspect. Recent findings suggest that iPSC and their derivates are not immunoprivileged and can be rejected upon transplantation. Dendritic cells (DCs) are the major antigen presenting cells to T cells and are key in triggering both the innate and adaptive immune responses. In addition to killing tumor and virus-infected cells, natural killer (NK) cells distinguish allogeneic major histocompatibility complex (MHC) and are participate in transplant rejection. Here we examined the immunomodulatory properties of hESCs and hESCs-derived cardiomyocytes (hESCs-…-
dc.languageeng-
dc.relation.ispartofDays of Molecular Medicine Meeting, DMM 2011-
dc.titleDistinct immunomodulatory effects of human embryonic stem cells (hESC) and hESC-derived cardiomyocytes on human dendritic cells and natural killer cells-
dc.typeConference_Paper-
dc.identifier.emailTso, GHW: gloriatw@hku.hk-
dc.identifier.emailYim, ALY: ayim@hku.hk-
dc.identifier.emailLi, RA: ronaldli@hkucc.hku.hk-
dc.identifier.emailChan, CWY: camchan@hku.hk-
dc.identifier.authorityLi, RA=rp01352-
dc.identifier.authorityChan, CWY=rp01311-
dc.description.naturepostprint-
dc.identifier.hkuros207926-

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